ES8800947A1 - Procedimiento para la obtencion de nuevos derivados de la pirrolo (1.2-a) azepinona - Google Patents

Procedimiento para la obtencion de nuevos derivados de la pirrolo (1.2-a) azepinona

Info

Publication number
ES8800947A1
ES8800947A1 ES556722A ES556722A ES8800947A1 ES 8800947 A1 ES8800947 A1 ES 8800947A1 ES 556722 A ES556722 A ES 556722A ES 556722 A ES556722 A ES 556722A ES 8800947 A1 ES8800947 A1 ES 8800947A1
Authority
ES
Spain
Prior art keywords
alkyl
optionally substituted
alkyloxy
substituted
alkylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556722A
Other languages
English (en)
Other versions
ES556722A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of ES556722A0 publication Critical patent/ES556722A0/es
Publication of ES8800947A1 publication Critical patent/ES8800947A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

METODO DE OBTENER NUEVOS DERIVADOS DE LA PIRROLO1,2-AZEPINONA. CONSISTE EN HACER REACCIONAR UN PRODUCTO DE FORMULA R4X SOBRE UN PRODUCTO DE FORMULA (II), EN UN DISOLVENTE CLORADO A UNA TEMPERATURA ENTRE LA DE REFLUJO Y LA DE LA MEZCLA REACCIONAL, EN PRESENCIA DE UN ACEPTOR DE ACIDO, Y AISLAR EL PRODUCTO OBTENIDO Y TRANSFORMARLO EN UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL PRODUCTO DESEADO DE FORMULA (I), DONDE R3 ES UN ATOMO DE H O DE HALOGENO, R ES UN RADICAL FENILO, Y R1 Y R2 FORMAN, JUNTO CON EL ATOMO DE NITROGENO CON EL QUE ESTAN ENLAZADOS UN CICLO PIPERIZINA U HOMOPIPERIZINA SUSTITUIDOS POR UN RADICAL HIDROXIALQUILO. TIENEN UTILIDAD PARA PREPARAR COMPOSICIONES FARMACEUTICAS.
ES556722A 1985-03-15 1986-06-25 Procedimiento para la obtencion de nuevos derivados de la pirrolo (1.2-a) azepinona Expired ES8800947A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8503840A FR2578842B1 (fr) 1985-03-15 1985-03-15 Nouveaux derives de la pyrrolo(1,2-a) azepinone, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
ES556722A0 ES556722A0 (es) 1987-12-01
ES8800947A1 true ES8800947A1 (es) 1987-12-01

Family

ID=9317228

Family Applications (2)

Application Number Title Priority Date Filing Date
ES553028A Expired ES8801275A1 (es) 1985-03-15 1986-03-14 Procedimiento para la obtencion de nuevos derivados de la pirrolo (1,2-a) azepinona.
ES556722A Expired ES8800947A1 (es) 1985-03-15 1986-06-25 Procedimiento para la obtencion de nuevos derivados de la pirrolo (1.2-a) azepinona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES553028A Expired ES8801275A1 (es) 1985-03-15 1986-03-14 Procedimiento para la obtencion de nuevos derivados de la pirrolo (1,2-a) azepinona.

Country Status (23)

Country Link
US (2) US4769366A (es)
EP (1) EP0196955B1 (es)
JP (1) JPS61215392A (es)
KR (1) KR860007262A (es)
AT (1) ATE44032T1 (es)
AU (1) AU576064B2 (es)
CA (1) CA1261323A (es)
CS (2) CS253746B2 (es)
DD (1) DD251351A5 (es)
DE (1) DE3663948D1 (es)
DK (1) DK118886A (es)
ES (2) ES8801275A1 (es)
FI (2) FI861071A (es)
FR (1) FR2578842B1 (es)
GR (1) GR860672B (es)
HU (1) HU195510B (es)
IL (1) IL78135A (es)
MA (1) MA20638A1 (es)
NZ (1) NZ215471A (es)
PT (1) PT82182B (es)
SU (2) SU1447285A3 (es)
TN (1) TNSN86037A1 (es)
ZA (1) ZA861881B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020845A1 (en) 1995-12-01 1997-06-12 Suntory Limited Pyrroloazepine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1189553B (de) * 1962-08-09 1965-03-25 Degussa Verfahren zur Herstellung von racemischen und optisch aktiven Piperazinderivaten
DE2557341A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPS61215392A (ja) 1986-09-25
US4769366A (en) 1988-09-06
SU1447285A3 (ru) 1988-12-23
HUT42773A (en) 1987-08-28
FR2578842B1 (fr) 1987-04-10
EP0196955A1 (fr) 1986-10-08
GR860672B (en) 1986-05-27
DK118886D0 (da) 1986-03-14
US4826974A (en) 1989-05-02
TNSN86037A1 (fr) 1990-01-01
EP0196955B1 (fr) 1989-06-14
ES556722A0 (es) 1987-12-01
PT82182B (fr) 1988-01-07
DD251351A5 (de) 1987-11-11
PT82182A (fr) 1986-04-01
SU1537139A3 (ru) 1990-01-15
ZA861881B (en) 1986-12-30
FI892181A0 (fi) 1989-05-05
ATE44032T1 (de) 1989-06-15
CA1261323A (fr) 1989-09-26
MA20638A1 (fr) 1986-10-01
FI861071A (fi) 1986-09-16
CS253750B2 (cs) 1987-12-17
ES553028A0 (es) 1987-12-16
NZ215471A (en) 1988-08-30
FI861071A0 (fi) 1986-03-14
DE3663948D1 (en) 1989-07-20
CS253746B2 (en) 1987-12-17
AU576064B2 (en) 1988-08-11
FR2578842A1 (fr) 1986-09-19
DK118886A (da) 1986-09-16
IL78135A (en) 1989-02-28
IL78135A0 (en) 1986-07-31
ES8801275A1 (es) 1987-12-16
AU5470186A (en) 1986-09-18
KR860007262A (ko) 1986-10-10
HU195510B (en) 1988-05-30
FI892181A (fi) 1989-05-05

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401