ES8800149A1 - Un procedimiento para preparar derivados de 3-carbonil-1-aminoalquil-1h-indol - Google Patents

Un procedimiento para preparar derivados de 3-carbonil-1-aminoalquil-1h-indol

Info

Publication number
ES8800149A1
ES8800149A1 ES552912A ES552912A ES8800149A1 ES 8800149 A1 ES8800149 A1 ES 8800149A1 ES 552912 A ES552912 A ES 552912A ES 552912 A ES552912 A ES 552912A ES 8800149 A1 ES8800149 A1 ES 8800149A1
Authority
ES
Spain
Prior art keywords
aminoalkyl
analgesics
carbonyl
preparation
arylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552912A
Other languages
English (en)
Other versions
ES552912A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES552912A0 publication Critical patent/ES552912A0/es
Publication of ES8800149A1 publication Critical patent/ES8800149A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 3-CARBONIL-1-AMINOALQUIL-1H-INDOL. CONSISTE EN HACER REACCIONAR UN (2-HALO-ALQUILO INFERIOR)1H-INDOL DE FORMULA (II) CON UNA AMINA DE FORMULA (H N=B), A LA TEMPERATURA DE EBULLICION DEL DISOLVENTE, EN UN SOLVENTE INERTE (ACETONITRILO) Y EN PRESENCIA DE UN ACEPTOR DE ACIDO (PIRIDINA), PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO. SIENDO. ALK, UN ALFA-OMEGA-ALQUILENO INFERIOR DE FORMULA (CH2)N; R2 Y R4, H, ALQUILO INFERIOR Y OTROS; R3, CICLOHEXILO, FENILO Y OTROS; N=B, AZIDO, N-ALQUIL INFERIOR AMINO Y OTROS; X'', UN GRUPO HALO; Y N, DE 2 A 6. SE UTILIZAN COMO AGENTES ANALGESICOS Y ANTIINFLAMATORIOS. *FORMULA*
ES552912A 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de 3-carbonil-1-aminoalquil-1h-indol Expired ES8800149A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63793184A 1984-08-06 1984-08-06

Publications (2)

Publication Number Publication Date
ES552912A0 ES552912A0 (es) 1987-10-16
ES8800149A1 true ES8800149A1 (es) 1987-10-16

Family

ID=24557949

Family Applications (5)

Application Number Title Priority Date Filing Date
ES545894A Expired ES8609246A1 (es) 1984-08-06 1985-08-05 Un procedimiento para preparar un derivado de 3-carbonil-1- aminoalquil-1h-indol
ES552909A Expired ES8800901A1 (es) 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de indol
ES552910A Expired ES8801203A1 (es) 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de indol
ES552911A Expired ES8800902A1 (es) 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de 3-carbonil-1-aminoalquil-1h-indol
ES552912A Expired ES8800149A1 (es) 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de 3-carbonil-1-aminoalquil-1h-indol

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES545894A Expired ES8609246A1 (es) 1984-08-06 1985-08-05 Un procedimiento para preparar un derivado de 3-carbonil-1- aminoalquil-1h-indol
ES552909A Expired ES8800901A1 (es) 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de indol
ES552910A Expired ES8801203A1 (es) 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de indol
ES552911A Expired ES8800902A1 (es) 1984-08-06 1986-03-12 Un procedimiento para preparar derivados de 3-carbonil-1-aminoalquil-1h-indol

Country Status (20)

Country Link
EP (1) EP0171037B1 (es)
JP (1) JPH0670010B2 (es)
KR (1) KR870000548B1 (es)
AR (1) AR244665A1 (es)
AT (1) ATE77371T1 (es)
AU (1) AU574817B2 (es)
DE (1) DE3586224T2 (es)
DK (1) DK170279B1 (es)
ES (5) ES8609246A1 (es)
FI (1) FI852973L (es)
GR (1) GR851937B (es)
IE (1) IE57863B1 (es)
IL (1) IL75966A (es)
MX (4) MX160612A (es)
MY (1) MY101186A (es)
NO (1) NO169067C (es)
NZ (3) NZ225467A (es)
PH (2) PH23498A (es)
PT (1) PT80919B (es)
ZA (1) ZA855923B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
US4840950A (en) * 1987-02-11 1989-06-20 Sterling Drug Inc. 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
US5312829A (en) * 1990-05-21 1994-05-17 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives
GB9011335D0 (en) * 1990-05-21 1990-07-11 Fujisawa Pharmaceutical Co Indolebutyric acid derivatives and process for preparation thereof
GB9204365D0 (en) * 1992-02-28 1992-04-08 Pfizer Ltd Indoles
TW270114B (es) * 1993-10-22 1996-02-11 Hoffmann La Roche
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
WO2001016101A1 (fr) * 1999-08-26 2001-03-08 Fujisawa Pharmaceutical Co., Ltd. Procede de preparation de derives de l'indole ou de leurs sels
JP6493786B2 (ja) * 2015-01-06 2019-04-03 パナソニックＩｐマネジメント株式会社 免疫原、それを用いた抗体の製造方法、及び、そのモノクローナル抗体
JP6435505B2 (ja) * 2015-01-13 2018-12-12 パナソニックＩｐマネジメント株式会社 化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
US3217011A (en) * 1965-05-07 1965-11-09 Sterling Drug Inc 1-(indolyglyoxalyl)-piperidines
US3489770A (en) * 1967-12-18 1970-01-13 American Home Prod 1-cyclo(lower)alkanoyl or admantanylcarbonyl - 3 - (2-substituted ethyl)indoles
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
FR2354766A1 (fr) * 1976-06-17 1978-01-13 Labaz Derives n-aminoalkyles d'indole et procedes pour les preparer
ES8605232A1 (es) * 1984-02-07 1986-03-16 Pfizer Un procedimiento para la preparacion de compuestos de 2-o- xindol

Also Published As

Publication number Publication date
MX14429A (es) 1993-09-01
ES8800902A1 (es) 1987-12-01
ES8801203A1 (es) 1987-12-16
JPH0670010B2 (ja) 1994-09-07
DK354485A (da) 1986-02-07
IE851930L (en) 1986-02-06
IL75966A0 (en) 1985-12-31
ES552909A0 (es) 1987-12-01
ES552910A0 (es) 1987-12-16
NO853066L (no) 1986-02-07
NZ225467A (en) 1990-02-26
AU574817B2 (en) 1988-07-14
DK354485D0 (da) 1985-08-05
IE57863B1 (en) 1993-05-05
DE3586224D1 (de) 1992-07-23
EP0171037B1 (en) 1992-06-17
ZA855923B (en) 1986-03-26
ES552912A0 (es) 1987-10-16
FI852973A0 (fi) 1985-08-01
DK170279B1 (da) 1995-07-24
ES8800901A1 (es) 1987-12-01
EP0171037A3 (en) 1987-08-26
FI852973L (fi) 1986-02-07
PH25360A (en) 1991-05-13
IL75966A (en) 1989-08-15
KR860001805A (ko) 1986-03-22
JPS6147463A (ja) 1986-03-07
DE3586224T2 (de) 1993-01-28
MX14431A (es) 1993-08-01
PT80919B (pt) 1987-09-30
NZ212953A (en) 1990-02-26
NO169067C (no) 1992-05-06
ES552911A0 (es) 1987-12-01
NO169067B (no) 1992-01-27
MX14432A (es) 1993-08-01
EP0171037A2 (en) 1986-02-12
AR244665A1 (es) 1993-11-30
PH23498A (en) 1989-08-16
MX160612A (es) 1990-03-28
ES545894A0 (es) 1986-07-16
ES8609246A1 (es) 1986-07-16
MY101186A (en) 1991-07-31
GR851937B (es) 1985-12-05
KR870000548B1 (ko) 1987-03-18
PT80919A (en) 1985-09-01
NZ225466A (en) 1990-02-26
AU4576485A (en) 1986-02-13
ATE77371T1 (de) 1992-07-15

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506