ES8707965A1 - Procedimiento para preparar complejos de (1-bencil-etilendiamin)-platino (ii) - Google Patents
Procedimiento para preparar complejos de (1-bencil-etilendiamin)-platino (ii)Info
- Publication number
- ES8707965A1 ES8707965A1 ES552261A ES552261A ES8707965A1 ES 8707965 A1 ES8707965 A1 ES 8707965A1 ES 552261 A ES552261 A ES 552261A ES 552261 A ES552261 A ES 552261A ES 8707965 A1 ES8707965 A1 ES 8707965A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- radicals
- radical
- group
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 229910052697 platinum Inorganic materials 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title 1
- -1 phenoxy, benzyloxy Chemical group 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 150000001450 anions Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- CXFFQOZYXJHZNJ-UHFFFAOYSA-N 3-phenylpropane-1,2-diamine Chemical compound NCC(N)CC1=CC=CC=C1 CXFFQOZYXJHZNJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPLEJOS DE (1-BENCIL-ETILENDIAMINO)-PLATINO-(II), DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN ACIDO TETRAHALOGENO-PLATINICO-(II), UNA SAL COMPLEJA DE TETRAHALOGENO-PLATINO-(II) CON DOS CATIONES MONOVALENTES O CON UN CATION DIVALENTE, O UN HALOGENURO DE PLATINO-(II), CON UN COMPUESTO DE FORMULA GENERAL (II) O CON UNA SAL DE DICHO COMPUESTO, CON UN ION ANTAGONISTA FISIOLOGICAMENTE COMPATIBLE, O CON UNA SAL POR ADICION DE ACIDO DEL COMPUESTO DE FORMULA GENERAL (II), EFECTUANDOSE DICHA REACCION A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 90 GRADOS Y A UN PH DEL MEDIO DE REACCION COMPRENDIDO ENTRE 5 Y 7. DE APLICACION EN MEDICINA Y FARMACIA POR SUS EFECTOS ANTITUMORALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3506468 | 1985-02-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES552261A0 ES552261A0 (es) | 1987-09-01 |
| ES8707965A1 true ES8707965A1 (es) | 1987-09-01 |
Family
ID=6263432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES552261A Expired ES8707965A1 (es) | 1985-02-23 | 1986-02-21 | Procedimiento para preparar complejos de (1-bencil-etilendiamin)-platino (ii) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4704464A (es) |
| EP (1) | EP0193083A1 (es) |
| JP (1) | JPS61194093A (es) |
| AU (1) | AU5363886A (es) |
| CA (1) | CA1268182A (es) |
| DD (1) | DD253625A5 (es) |
| DK (1) | DK82686A (es) |
| ES (1) | ES8707965A1 (es) |
| FI (1) | FI860731A (es) |
| GR (1) | GR860501B (es) |
| HU (1) | HU195830B (es) |
| NO (1) | NO860626L (es) |
| PT (2) | PT82053B (es) |
| ZA (1) | ZA86704B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3012698A (en) * | 1957-09-18 | 1961-12-12 | George A Nelson | Resilient dispensing tube |
| US5116831A (en) * | 1985-12-24 | 1992-05-26 | Warner-Lambert Company | Aminoalkyl-substituted cycloalkylamine platinum (II) complexes |
| US4970324A (en) * | 1985-12-24 | 1990-11-13 | Hoeschele James D | Aminoalkyl-substituted azetidine platinum(II) complexes |
| JPS6310726A (ja) * | 1986-03-11 | 1988-01-18 | Chugai Pharmaceut Co Ltd | 白金錯体を有効成分として含有する制癌剤 |
| EP0262498B1 (de) * | 1986-10-03 | 1990-05-30 | ASTA Pharma Aktiengesellschaft | Diamin-platin (II)-Komplexverbindungen mit einem hydroxylierten 2-Phenyl-Indolring |
| US5238955A (en) * | 1990-04-10 | 1993-08-24 | Asta Pharma Ag | Ethylene-substituted phenylalkylethylenediamine-platinum (II or IV) derivatives and phenylalkylethylenediamines |
| NZ237443A (en) * | 1990-04-10 | 1993-11-25 | Asta Medica Ag | Phenalkylethylenediamine and aminomethyltetra hydroisoquinoline derivatives, platinum (ii) and (iv) complexes, methods of preparation and pharmaceutical compositions |
| US5455271A (en) * | 1992-06-18 | 1995-10-03 | The Scripps Research Institute | Tight-binding inhibitors of leukotriene A4 hydrolase |
| WO2000003718A1 (fr) * | 1997-01-14 | 2000-01-27 | Toray Industries, Inc. | Preparations lyophilisees et procede de production |
| FR2809012A1 (fr) * | 2000-05-18 | 2001-11-23 | Oreal | Extrait de cellules d'au moins un vegetal de la famille pontederiaceae et son utilisation comme agent anti-pollution |
| DE10141528B4 (de) * | 2001-08-24 | 2006-08-10 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Platin(II)- und Platin(IV)-Komplexe und ihre Verwendung |
| US7087214B2 (en) * | 2002-02-01 | 2006-08-08 | Zentaris Gmbh | Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases |
| WO2004006859A2 (en) * | 2002-07-16 | 2004-01-22 | Sonus Pharmaceuticals, Inc. | Platinum compound |
| CA2560059A1 (en) * | 2004-03-15 | 2005-09-29 | Sonus Pharmaceuticals, Inc. | Platinum carboxylate anticancer compounds |
| CN113135962A (zh) * | 2021-05-07 | 2021-07-20 | 内江洛伯尔材料科技有限公司 | 高水溶性铂催化剂前驱体及其合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH605550A5 (es) * | 1972-06-08 | 1978-09-29 | Research Corp | |
| SE7903361L (sv) * | 1978-04-20 | 1979-10-21 | Johnson Matthey Co Ltd | Kompositioner innehallande platina |
| US4234500A (en) * | 1979-03-07 | 1980-11-18 | Engelhard Minerals & Chemicals Corporation | Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes |
| JPS5716895A (en) * | 1980-07-05 | 1982-01-28 | Otsuka Chem Co Ltd | Platinum 2 complex and antitumor agent containing the same as active principle |
| US4598091A (en) * | 1983-02-18 | 1986-07-01 | Degussa Aktiengesellschaft | (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds |
| US4562275A (en) * | 1984-03-23 | 1985-12-31 | Bristol-Myers Co. | Antitumor platinum complexes |
-
1986
- 1986-01-30 ZA ZA86704A patent/ZA86704B/xx unknown
- 1986-02-17 AU AU53638/86A patent/AU5363886A/en not_active Abandoned
- 1986-02-18 EP EP86102092A patent/EP0193083A1/de not_active Withdrawn
- 1986-02-19 NO NO860626A patent/NO860626L/no unknown
- 1986-02-19 FI FI860731A patent/FI860731A/fi not_active Application Discontinuation
- 1986-02-20 DD DD86287196A patent/DD253625A5/de unknown
- 1986-02-20 PT PT82053A patent/PT82053B/pt unknown
- 1986-02-20 PT PT82052A patent/PT82052B/pt unknown
- 1986-02-21 GR GR860501A patent/GR860501B/el unknown
- 1986-02-21 US US06/831,911 patent/US4704464A/en not_active Expired - Fee Related
- 1986-02-21 DK DK82686A patent/DK82686A/da not_active Application Discontinuation
- 1986-02-21 CA CA000502459A patent/CA1268182A/en not_active Expired - Lifetime
- 1986-02-21 ES ES552261A patent/ES8707965A1/es not_active Expired
- 1986-02-21 HU HU86739A patent/HU195830B/hu unknown
- 1986-02-24 JP JP61037537A patent/JPS61194093A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GR860501B (en) | 1986-06-18 |
| EP0193083A1 (de) | 1986-09-03 |
| PT82053A (de) | 1986-03-01 |
| DD253625A5 (de) | 1988-01-27 |
| FI860731A (fi) | 1986-08-24 |
| US4704464A (en) | 1987-11-03 |
| CA1268182A (en) | 1990-04-24 |
| FI860731A0 (fi) | 1986-02-19 |
| PT82053B (de) | 1987-11-09 |
| ZA86704B (en) | 1986-10-29 |
| NO860626L (no) | 1986-08-25 |
| DK82686D0 (da) | 1986-02-21 |
| AU5363886A (en) | 1986-09-04 |
| HU195830B (en) | 1988-07-28 |
| ES552261A0 (es) | 1987-09-01 |
| PT82052B (de) | 1987-11-09 |
| PT82052A (de) | 1986-03-01 |
| DK82686A (da) | 1986-08-24 |
| JPS61194093A (ja) | 1986-08-28 |
| HUT40452A (en) | 1986-12-28 |
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