ES8607946A1 - Un procedimiento para preparar 1-imidazolilmetilestirenos - Google Patents

Un procedimiento para preparar 1-imidazolilmetilestirenos

Info

Publication number
ES8607946A1
ES8607946A1 ES544859A ES544859A ES8607946A1 ES 8607946 A1 ES8607946 A1 ES 8607946A1 ES 544859 A ES544859 A ES 544859A ES 544859 A ES544859 A ES 544859A ES 8607946 A1 ES8607946 A1 ES 8607946A1
Authority
ES
Spain
Prior art keywords
preparation
drugs
imidazolyl compounds
compounds
imidazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544859A
Other languages
English (en)
Other versions
ES544859A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES544859A0 publication Critical patent/ES544859A0/es
Publication of ES8607946A1 publication Critical patent/ES8607946A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 1-IMIDAZOLILMETILESTIRENOS. COMPRENDE: A) HACER REACCIONAR A UN C.D.F. (II) CON UN C.D.F (III) SEGUN HORNER-EMMONS-WITTIG, DURANTE 1 A 36 HORAS, PARA OBTENER UN C.D.F (IV); B) TRATAR A UN C.D.F (IV) CON UN BORANATO DE SODIO, ENTRE C10JC Y LA TEMPERATURA AMBIENTE Y EN ETANOL, PARA OBTENER UN C.D.F (V); Y C) HACER REACCIONAR A (V) CON CLORURODE ACIDO NICOTINICO, EN PRESENCIA DE PIRIDINA, PARA OBTENER UN C.D.F (I) Y SUS SALES DE ADICION DE ACIDOS INORGANICOS U ORGANICOS. SIENDO: R1 Y R2 CONJUNTAMENTE O DE UNG RUPO CARBONILO Y SEPARADAMENTE R1H Y R2 COR4; R3 UN RADICAL FENILO SUSTITUIDO DE 1 A 3 VECES CON HALOGENO O TRIFLUOROMETILO; R4 H, RADICAL BENCILOCARBONILO Y OTROS; R5 ALQUILO DE C 1 A 4 Y C.D.F COMPUESTO DE FORMULA. SE UTILIZAN COMO INHIBIDORES DE TROMBOXANO.
ES544859A 1984-07-06 1985-07-04 Un procedimiento para preparar 1-imidazolilmetilestirenos Expired ES8607946A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843424944 DE3424944A1 (de) 1984-07-06 1984-07-06 Neue imidazolyverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES544859A0 ES544859A0 (es) 1986-06-01
ES8607946A1 true ES8607946A1 (es) 1986-06-01

Family

ID=6240014

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544859A Expired ES8607946A1 (es) 1984-07-06 1985-07-04 Un procedimiento para preparar 1-imidazolilmetilestirenos

Country Status (9)

Country Link
US (1) US4665080A (es)
EP (1) EP0169408B1 (es)
JP (1) JPS6124574A (es)
AT (1) ATE43585T1 (es)
DE (2) DE3424944A1 (es)
DK (1) DK308785A (es)
ES (1) ES8607946A1 (es)
GR (1) GR851642B (es)
PT (1) PT80759B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4204686A1 (de) * 1992-02-17 1993-08-19 Gruenenthal Gmbh Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln
DE4220983A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate
MXPA02008536A (es) * 2000-04-17 2002-12-13 Warner Lambert Co Inhibidores dihidro-2h-naftaleno-1-ona de la transferasa ras farnesil.
CN103467383B (zh) * 2013-09-13 2015-07-15 上海海虹实业(集团)巢湖今辰药业有限公司 一种丹皮酚与奥扎格雷偶联物及其药物组合物、医药用途
CN106432189A (zh) * 2016-09-21 2017-02-22 安徽省逸欣铭医药科技有限公司 苯丙烯酰胺衍生物及其制备方法和医药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55313A (en) * 1978-06-13 1980-01-05 Kissei Pharmaceut Co Ltd Imidazole derivative
DK531479A (da) * 1979-01-19 1980-07-20 Pfizer Fremgangsmaade til fremstilling af imidazolderivater og salte deraf
IL69487A (en) * 1982-08-14 1987-01-30 Wellcome Found Imidazole derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0169408B1 (de) 1989-05-31
DK308785D0 (da) 1985-07-05
DE3570660D1 (en) 1989-07-06
ES544859A0 (es) 1986-06-01
DE3424944A1 (de) 1986-02-06
GR851642B (es) 1985-11-26
PT80759A (de) 1985-08-01
EP0169408A1 (de) 1986-01-29
ATE43585T1 (de) 1989-06-15
JPS6124574A (ja) 1986-02-03
US4665080A (en) 1987-05-12
PT80759B (pt) 1987-09-30
DK308785A (da) 1986-01-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203