ES8706835A1 - Un procedimiento para preparar compuestos de antraciclina - Google Patents

Un procedimiento para preparar compuestos de antraciclina

Info

Publication number
ES8706835A1
ES8706835A1 ES556415A ES556415A ES8706835A1 ES 8706835 A1 ES8706835 A1 ES 8706835A1 ES 556415 A ES556415 A ES 556415A ES 556415 A ES556415 A ES 556415A ES 8706835 A1 ES8706835 A1 ES 8706835A1
Authority
ES
Spain
Prior art keywords
medicaments
preparation
chem
anthracycline compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556415A
Other languages
English (en)
Other versions
ES556415A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES556415A0 publication Critical patent/ES556415A0/es
Publication of ES8706835A1 publication Critical patent/ES8706835A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

METODO DE PREPARAR COMPUESTOS DE ANTRACICLINA. CONSISTE EN CULTIVAR, EN CONDICIONES AEROBIAS, A TEMPERATURA ENTRE 20 Y 35GC Y DURANTE 3 A 5 DIAS, UNA CEPA DE MICROORGANISMO DEL GENERO ACTINOMADURA, QUE ES CAPAZ DE PRODUCIR LOS COMPUESTOS EN UN MEIDO NUTRIENTE QUE TIENE FUENTES DE CARBNO, DE NITROGENO Y OPCIONALMENTE SALES ORGANICAS Y/O AGENTES ANTIESPUMANTES; RECUPERAR LOS COMPUESTOS PRODUCIDOS POR EXTRACCION CON DISOLVENTES ORGANICOS, SOMETER LOS EXTRACTOS A CROMATOGRAFIA Y REDUCIR EL COMPUESTO OBTENIDO DE FORMULA (I), DONDE R ES UNA CUALQUIERA DE LAS FORMULAS (II) O (III) Y OTRAS. TIENEN APLICACIONES FARMACEUTICAS COMO AGENTES ANTITUMORALES Y ANTIMICROBIANOS. *FORMULA*
ES556415A 1985-06-24 1986-06-23 Un procedimiento para preparar compuestos de antraciclina Expired ES8706835A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60137193A JPS6297A (ja) 1985-06-24 1985-06-24 アントラサイクリン化合物

Publications (2)

Publication Number Publication Date
ES556415A0 ES556415A0 (es) 1987-07-01
ES8706835A1 true ES8706835A1 (es) 1987-07-01

Family

ID=15192969

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556415A Expired ES8706835A1 (es) 1985-06-24 1986-06-23 Un procedimiento para preparar compuestos de antraciclina

Country Status (10)

Country Link
EP (1) EP0206138B1 (es)
JP (1) JPS6297A (es)
AT (1) ATE41155T1 (es)
DE (1) DE3662270D1 (es)
DK (1) DK293986A (es)
ES (1) ES8706835A1 (es)
GR (1) GR861600B (es)
HU (1) HU198102B (es)
PT (1) PT82825B (es)
ZA (1) ZA864661B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8606204D0 (en) * 1986-03-13 1986-04-16 Erba Farmitalia Biosynthetic anthracyclines
JPH02145598A (ja) * 1988-11-29 1990-06-05 Snow Brand Milk Prod Co Ltd 新規アンスラサイクリン系化合物及びこれを含有する抗腫瘍剤
JP2779652B2 (ja) * 1988-12-27 1998-07-23 武田薬品工業株式会社 生理活性物質ｔａｎ―１１２０，その還元体，それらの製造法および用途ならびに微生物
GB2315067B (en) * 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL124284B1 (en) * 1979-10-17 1983-01-31 Politechnika Gdanska Process for preparing n-glycosyl derivatives of antibiotics from anthracyclines group

Also Published As

Publication number Publication date
JPS6297A (ja) 1987-01-06
EP0206138B1 (en) 1989-03-08
ES556415A0 (es) 1987-07-01
EP0206138A1 (en) 1986-12-30
HUT45563A (en) 1988-07-28
ATE41155T1 (de) 1989-03-15
JPH0479355B2 (es) 1992-12-15
GR861600B (en) 1986-10-20
PT82825A (en) 1986-07-01
DK293986A (da) 1986-12-25
PT82825B (pt) 1988-12-15
DK293986D0 (da) 1986-06-23
HU198102B (en) 1989-07-28
DE3662270D1 (en) 1989-04-13
ZA864661B (en) 1987-03-25

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506