ES8706614A1 - Procedimiento para la preparacion de 2-(4-isobutilfenil)-acido propiohidorxamico - Google Patents

Procedimiento para la preparacion de 2-(4-isobutilfenil)-acido propiohidorxamico

Info

Publication number
ES8706614A1
ES8706614A1 ES554309A ES554309A ES8706614A1 ES 8706614 A1 ES8706614 A1 ES 8706614A1 ES 554309 A ES554309 A ES 554309A ES 554309 A ES554309 A ES 554309A ES 8706614 A1 ES8706614 A1 ES 8706614A1
Authority
ES
Spain
Prior art keywords
isobutylphenyl
acid
propiohydroxamic
methylene chloride
room temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554309A
Other languages
English (en)
Other versions
ES554309A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Publication of ES554309A0 publication Critical patent/ES554309A0/es
Publication of ES8706614A1 publication Critical patent/ES8706614A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO DE OBTENER 2-(4-ISOBUTIFENIL)-ACIDO PROPIOHIDROXAMICO. CONSISTE EN HACER REACCIONAR BIS[2-(4-ISOBUTIFENIL)-ACIDO PROPIONICO]ANHIDRICO DE FORMULA (II) CON HIDROXILAMINA O SU SAL DE HIDROCLORURO, EN UN DISOLVENTE ORGANICO, TAL COMO ACETONITRILO, CLORURO DE METILENO, ALCOHOLES ALIFATICOS INFERIORES CON C 1 A 5, DIMETILFORMAMIDA Y OTROS, BAJO EXCLUSION DE HUMEDAD ATMOSFERICA, EN UN TIEMPO MUY CORTO Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 60GC, PARA OBTENER 2-(4-ISOBUTIFENIL)-ACIDO PROPIOHIDROXAMICO DE FORMULA (I). TIENEN APLICACIONES FARMACEUTICAS POR SUS EFECTOS ANALGESICOS Y ANTIPIRETICOS. *FORMULA*
ES554309A 1985-04-26 1986-04-24 Procedimiento para la preparacion de 2-(4-isobutilfenil)-acido propiohidorxamico Expired ES8706614A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU70985A YU43408B (en) 1985-04-26 1985-04-26 Process for preparation of 2-(4-isobuthylphenyl)-prophiohydroxamic acid

Publications (2)

Publication Number Publication Date
ES554309A0 ES554309A0 (es) 1987-07-01
ES8706614A1 true ES8706614A1 (es) 1987-07-01

Family

ID=25551093

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554309A Expired ES8706614A1 (es) 1985-04-26 1986-04-24 Procedimiento para la preparacion de 2-(4-isobutilfenil)-acido propiohidorxamico

Country Status (5)

Country Link
EP (1) EP0203379A1 (es)
JP (1) JPS61263950A (es)
DK (1) DK188786A (es)
ES (1) ES8706614A1 (es)
YU (1) YU43408B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300470A (en) * 1993-09-10 1995-04-30 Lek Tovarna Farmacevtskih Inclusion complexes of optically active and racemic ibuproxan with cyclodextrin derivates,process for their preparation,pharmaceutical preparations comprising the same and their use
JP2000511047A (ja) 1996-05-20 2000-08-29 フラウンホッフェル―ゲゼルシャフト・ツール・フェルデルング・デア・アンゲバンドゥテン・フォルシュング・エー・ファウ 光学活性ヒドロキサム酸の酵素学的合成及びＬｏｓｓｅｎ転移によるそれらの光学活性一級アミンへの変換
CN102976974B (zh) * 2012-12-29 2015-01-21 吉首大学 苯基苄基丙酰-n-甲基氧肟酸类尿素酶抑制剂及其合成和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB894119A (en) * 1959-11-02 1962-04-18 Ici Ltd Pivalic acid derivative
JPS5826744B2 (ja) * 1975-12-24 1983-06-04 ヒサミツセイヤク カブシキガイシヤ シンキナプロピオンサン エステルユウドウタイノセイゾウホウ

Also Published As

Publication number Publication date
ES554309A0 (es) 1987-07-01
DK188786A (da) 1986-10-27
DK188786D0 (da) 1986-04-24
YU70985A (en) 1987-10-31
JPS61263950A (ja) 1986-11-21
EP0203379A1 (de) 1986-12-03
YU43408B (en) 1989-06-30

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