JPS5620545A - Preparation of half ester - Google Patents

Preparation of half ester

Info

Publication number
JPS5620545A
JPS5620545A JP9506079A JP9506079A JPS5620545A JP S5620545 A JPS5620545 A JP S5620545A JP 9506079 A JP9506079 A JP 9506079A JP 9506079 A JP9506079 A JP 9506079A JP S5620545 A JPS5620545 A JP S5620545A
Authority
JP
Japan
Prior art keywords
dmso
sodium salt
phenylacetate
hydride
carbon dioxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9506079A
Other languages
Japanese (ja)
Other versions
JPS6228774B2 (en
Inventor
Shigeo Kitamura
Kazuo Yoshioka
Yoshiharu Seriyama
Hiroshi Midorita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Soda Co Ltd
Shionogi and Co Ltd
Original Assignee
Nippon Soda Co Ltd
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Soda Co Ltd, Shionogi and Co Ltd filed Critical Nippon Soda Co Ltd
Priority to JP9506079A priority Critical patent/JPS5620545A/en
Priority to US06/170,910 priority patent/US4336196A/en
Priority to GB8024195A priority patent/GB2056444B/en
Priority to ES493730A priority patent/ES8106271A1/en
Priority to IT49348/80A priority patent/IT1143026B/en
Priority to FR8016505A priority patent/FR2462418A1/en
Priority to DE3028321A priority patent/DE3028321C2/en
Publication of JPS5620545A publication Critical patent/JPS5620545A/en
Publication of JPS6228774B2 publication Critical patent/JPS6228774B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a raw material for a variety of medicines, e.g. a penicillin antibiotic, readily and in high yield, by the treatment of a phenylacetate with a sodium salt of inexpensive DMSO and gaseous carbon dioxide.
CONSTITUTION: A phenylacetate of formula I (R1 is H, OH, alkyl, etc.; R2 is aryl, etc.) is treated with a sodium salt of DMSO and gaseous carbon dioxide, to give a half ester of phenylmalonic acid expressed by formula II. The sodium salt of DMSO is obtained, by the reaction of, for example, sodium amide or hydride, with 1.2W 1.5 times mole DMSO basing on the mole of sodium amide or hydride, at 50W70°C, and usually used as a solution in a nonpolar inert solvent, e.g. toluene or xylene.
COPYRIGHT: (C)1981,JPO&Japio
JP9506079A 1979-07-27 1979-07-27 Preparation of half ester Granted JPS5620545A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP9506079A JPS5620545A (en) 1979-07-27 1979-07-27 Preparation of half ester
US06/170,910 US4336196A (en) 1979-07-27 1980-07-21 Process for the production of phenylmalonic acid mono-esters
GB8024195A GB2056444B (en) 1979-07-27 1980-07-24 Process for the production of phenylmalonic acid mono-esters
ES493730A ES8106271A1 (en) 1979-07-27 1980-07-24 Process for the production of phenylmalonic acid mono-esters
IT49348/80A IT1143026B (en) 1979-07-27 1980-07-25 PROCEDURE FOR THE PRODUCTION OF PHENYLMALONIC ACID MONOESTERS
FR8016505A FR2462418A1 (en) 1979-07-27 1980-07-25 PROCESS FOR PRODUCING MONOESTERS OF PHENYLMALONIC ACID
DE3028321A DE3028321C2 (en) 1979-07-27 1980-07-25 Process for the preparation of phenylmalonic acid monoesters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9506079A JPS5620545A (en) 1979-07-27 1979-07-27 Preparation of half ester

Publications (2)

Publication Number Publication Date
JPS5620545A true JPS5620545A (en) 1981-02-26
JPS6228774B2 JPS6228774B2 (en) 1987-06-23

Family

ID=14127480

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9506079A Granted JPS5620545A (en) 1979-07-27 1979-07-27 Preparation of half ester

Country Status (1)

Country Link
JP (1) JPS5620545A (en)

Also Published As

Publication number Publication date
JPS6228774B2 (en) 1987-06-23

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