ES8705427A1 - Un procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-pirimidinil- o n-pirazinil-propilaminas - Google Patents

Un procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-pirimidinil- o n-pirazinil-propilaminas

Info

Publication number
ES8705427A1
ES8705427A1 ES551129A ES551129A ES8705427A1 ES 8705427 A1 ES8705427 A1 ES 8705427A1 ES 551129 A ES551129 A ES 551129A ES 551129 A ES551129 A ES 551129A ES 8705427 A1 ES8705427 A1 ES 8705427A1
Authority
ES
Spain
Prior art keywords
pyrazinylpropylamines
pyrrolidino
pyrimidinyl
alkoxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551129A
Other languages
English (en)
Other versions
ES551129A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Publication of ES551129A0 publication Critical patent/ES551129A0/es
Publication of ES8705427A1 publication Critical patent/ES8705427A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA (I). CONSISTENTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON OTRO DE FORMULA (III), DONDE AR REPRESENTA TIENILO, FURILO, PIRIDILO O UN GRUPO FENILO, OPCIONALMENTE SUSTITUIDO; R ES UN GRUPO ALQUILO LINEAL O RAMIFICADO DE 1 A 7 ATOMOS DE CARBONO; Y X1 Y X2 SON NITROGENO Y CARBONO; PARA OBTENER EL COMPUESTO (I) Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. LA REACCION SE PROMUEVE, PREFERIBLEMENTE, METALIZANDO EL COMPUESTO (III) EN UN AGENTE DE METAL ALCALINO COMO HIDRURO SODICO O AMIDURO DE SODIO, POTASIO O LITIO. DE APLICACION CONTRA LA ANGINA DE PECHO, LA HIPERTENSION Y LA DISRRITMIA.
ES551129A 1984-01-18 1986-01-22 Un procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-pirimidinil- o n-pirazinil-propilaminas Expired ES8705427A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8400757A FR2558160B1 (fr) 1984-01-18 1984-01-18 3-alkoxy 2-(n-pyrrolidino)-n-pyrimidinyl ou -pyrazinyl propylamines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES551129A0 ES551129A0 (es) 1987-05-01
ES8705427A1 true ES8705427A1 (es) 1987-05-01

Family

ID=9300252

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539626A Expired ES8607289A1 (es) 1984-01-18 1985-01-16 Procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-pirimidinil-o-n-pirazinil propilaminas.
ES551129A Expired ES8705427A1 (es) 1984-01-18 1986-01-22 Un procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-pirimidinil- o n-pirazinil-propilaminas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES539626A Expired ES8607289A1 (es) 1984-01-18 1985-01-16 Procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-pirimidinil-o-n-pirazinil propilaminas.

Country Status (11)

Country Link
US (1) US4762834A (es)
EP (1) EP0151062A3 (es)
JP (1) JPS60161971A (es)
KR (1) KR850005435A (es)
AU (1) AU567201B2 (es)
DK (1) DK20785A (es)
ES (2) ES8607289A1 (es)
FI (1) FI850153L (es)
FR (1) FR2558160B1 (es)
HU (1) HU193079B (es)
ZA (1) ZA85116B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE47846T1 (de) * 1985-06-21 1989-11-15 Ciba Geigy Ag Mikrobizide.
CH668969A5 (de) * 1986-09-05 1989-02-15 Ciba Geigy Ag Verfahren zur bekaempfung unerwuenschten pflanzenwuchses sowie zur regulierung des pflanzenwachstums.
US5185362A (en) * 1988-09-14 1993-02-09 Mcneilab, Inc. Diphenylamine cardiovascular agents, compositions and use
DK0612314T3 (da) * 1991-10-30 2000-05-29 Astra Ab 2-pyrazinylethylaminderivater og deres anvendelse som lægemidler

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2378024A1 (fr) * 1977-01-25 1978-08-18 Cerm Cent Europ Rech Mauvernay Nouvelle propylamine substituee, obtention et application

Also Published As

Publication number Publication date
ES539626A0 (es) 1986-05-16
FI850153L (fi) 1985-07-19
FI850153A0 (fi) 1985-01-14
ES551129A0 (es) 1987-05-01
DK20785D0 (da) 1985-01-17
FR2558160B1 (fr) 1986-05-30
KR850005435A (ko) 1985-08-26
AU567201B2 (en) 1987-11-12
JPS60161971A (ja) 1985-08-23
EP0151062A2 (fr) 1985-08-07
DK20785A (da) 1985-07-19
HU193079B (en) 1987-08-28
ES8607289A1 (es) 1986-05-16
FR2558160A1 (fr) 1985-07-19
US4762834A (en) 1988-08-09
EP0151062A3 (fr) 1985-08-21
ZA85116B (en) 1985-08-28
HUT37785A (en) 1986-02-28
AU3753785A (en) 1985-07-25

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