ES8704916A1 - Un metodo para la sintesis de una n-aril-1-moforlincarboximidamida. - Google Patents

Un metodo para la sintesis de una n-aril-1-moforlincarboximidamida.

Info

Publication number
ES8704916A1
ES8704916A1 ES552981A ES552981A ES8704916A1 ES 8704916 A1 ES8704916 A1 ES 8704916A1 ES 552981 A ES552981 A ES 552981A ES 552981 A ES552981 A ES 552981A ES 8704916 A1 ES8704916 A1 ES 8704916A1
Authority
ES
Spain
Prior art keywords
linogliride
guanidines
intermediates
producing
carboximidamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552981A
Other languages
English (en)
Other versions
ES552981A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of ES552981A0 publication Critical patent/ES552981A0/es
Publication of ES8704916A1 publication Critical patent/ES8704916A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/14—Compounds containing a carbon atom having four bonds to hetero atoms with a double bond to one hetero atom and at least one bond to a sulfur atom further doubly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE N-ARIL-1-MORFOLINCARBOXIMIDAMIDA, DE FORMULA (I). CONSISTE EN LA REACCION DE OXIDACION DE UNA N-ARILTIOUREA, DE FORMULA (II), CON PEROXIDO DE HIDROGENO, EN PRESENCIA DE UN CATALIZADOR DE MOLIBDENO; SEGUIDA DEL TRATAMIENTO DEL COMPUESTO FORMADO CON MORFOLINA PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE R PUEDE SER VARIOS RADICALES.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIDIABETICOS.
ES552981A 1985-03-15 1986-03-13 Un metodo para la sintesis de una n-aril-1-moforlincarboximidamida. Expired ES8704916A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/711,948 US4656270A (en) 1985-03-15 1985-03-15 Process for producing guanidines such as linogliride

Publications (2)

Publication Number Publication Date
ES552981A0 ES552981A0 (es) 1987-04-16
ES8704916A1 true ES8704916A1 (es) 1987-04-16

Family

ID=24860160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES552981A Expired ES8704916A1 (es) 1985-03-15 1986-03-13 Un metodo para la sintesis de una n-aril-1-moforlincarboximidamida.

Country Status (14)

Country Link
US (1) US4656270A (es)
EP (1) EP0195620A3 (es)
JP (1) JPS61263957A (es)
KR (1) KR860007211A (es)
CN (1) CN86102431A (es)
AU (1) AU5475686A (es)
DK (1) DK121386A (es)
ES (1) ES8704916A1 (es)
FI (1) FI861073A (es)
GR (1) GR860688B (es)
HU (1) HU194815B (es)
IL (1) IL78156A0 (es)
NO (1) NO860972L (es)
ZA (1) ZA861929B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948939A (en) * 1986-09-10 1999-09-07 Syntex (U.S.A.) Inc. Selective amidination of diamines
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
IN172842B (es) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
AU660104B2 (en) * 1992-06-10 1995-06-08 Mitsubishi Gas Chemical Company, Inc. Process for producing thiourea dioxide and bleaching of papermaking pulp with thiourea dioxide produced thereby

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587258A (en) * 1977-06-17 1981-04-01 Gea As Production of substituted guanidines
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
US4381395A (en) * 1981-04-03 1983-04-26 Sk & F Lab Co. Process for preparing an imidazole derivative

Also Published As

Publication number Publication date
ZA861929B (en) 1987-10-28
GR860688B (en) 1986-07-11
EP0195620A2 (en) 1986-09-24
US4656270A (en) 1987-04-07
KR860007211A (ko) 1986-10-08
HUT40621A (en) 1987-01-28
JPS61263957A (ja) 1986-11-21
HU194815B (en) 1988-03-28
FI861073A (fi) 1986-09-16
AU5475686A (en) 1986-09-18
ES552981A0 (es) 1987-04-16
FI861073A0 (fi) 1986-03-14
DK121386D0 (da) 1986-03-14
NO860972L (no) 1986-09-16
IL78156A0 (en) 1986-07-31
CN86102431A (zh) 1987-07-01
EP0195620A3 (en) 1987-08-19
DK121386A (da) 1986-09-16

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