ES8704001A1 - Un metodo de marcar un agente terapeutico o diagnostico con un ion de metal radiactivo - Google Patents

Un metodo de marcar un agente terapeutico o diagnostico con un ion de metal radiactivo

Info

Publication number
ES8704001A1
ES8704001A1 ES539927A ES539927A ES8704001A1 ES 8704001 A1 ES8704001 A1 ES 8704001A1 ES 539927 A ES539927 A ES 539927A ES 539927 A ES539927 A ES 539927A ES 8704001 A1 ES8704001 A1 ES 8704001A1
Authority
ES
Spain
Prior art keywords
radioactive metal
chelating
binding affinity
metal ion
diagnostic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539927A
Other languages
English (en)
Other versions
ES539927A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzo Biochem Inc
Original Assignee
Enzo Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzo Biochem Inc filed Critical Enzo Biochem Inc
Publication of ES8704001A1 publication Critical patent/ES8704001A1/es
Publication of ES539927A0 publication Critical patent/ES539927A0/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO PARA TRATAR UN AGENTE TERAPEUTICO O DIAGNOSTICO CON UN ION DE METAL RADIACTIVO. CONSISTE EN PONER EN CONTACTO: 1) UN AGENTE SIN MARCAR QUE COMPRENDE: A) UNA PORCION QUE SUSTANCIALMENTE NO FORMA QUELATOS CON METALES, UNIDA A B) UNA PORCION QUE FORMA QUELATOS, CAPAZ DE FORMARLOS CON EL ION DEL METAL RADIACTIVO Y QUE TIENE AFINIDAD POR ESTE; CON 2) UN MATERIAL DE TRANSFERENCIA DE IONES QUE TIENE UNIDO A EL EL ION METALICO Y QUE TIENE UNA AFINIDAD DE UNION PARA DICHO ION METALICO MENOR QUE LA AFINIDAD DE UNION DE LA PORCION QUE FORMA QUELATOS; FORMAR UN AGENTE TERAPEUTICO POR TRANSFERENCIA DEL ION METALICO DESDE LA ASOCIACION CON EL MATERIAL DE TRANSFERENCIA DE IONES A LA ASOCIACION CON EL AGENTE; Y SEPARAR EL AGENTE TERAPEUTICO O DE DIAGNOSTICO RADIOMARCADO, DEL MATERIAL DE TRANSFERENCIA DE IONES.TIENE UTILIDAD EN CLINICAS Y LABORATORIOS DE ANALISIS CON FINES DE DIAGNOSTICO.
ES539927A 1984-01-30 1985-01-29 Un metodo de marcar un agente terapeutico o diagnostico con un ion de metal radiactivo Expired ES8704001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/575,397 US4707352A (en) 1984-01-30 1984-01-30 Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group

Publications (2)

Publication Number Publication Date
ES8704001A1 true ES8704001A1 (es) 1987-03-01
ES539927A0 ES539927A0 (es) 1987-03-01

Family

ID=24300158

Family Applications (1)

Application Number Title Priority Date Filing Date
ES539927A Expired ES8704001A1 (es) 1984-01-30 1985-01-29 Un metodo de marcar un agente terapeutico o diagnostico con un ion de metal radiactivo

Country Status (11)

Country Link
US (3) US4707352A (es)
EP (1) EP0150844B1 (es)
JP (1) JPH0822822B2 (es)
AT (1) ATE92190T1 (es)
AU (1) AU597208B2 (es)
CA (1) CA1256023A (es)
DE (1) DE3587477T2 (es)
DK (1) DK39985A (es)
ES (1) ES8704001A1 (es)
IL (1) IL74187A (es)
NO (1) NO850353L (es)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175269A (en) * 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US5001072A (en) * 1984-05-23 1991-03-19 Icn Biomedicals Inc. Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US5221605A (en) * 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US4707544A (en) * 1984-11-28 1987-11-17 President And Fellows Of Harvard College Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
CA1293729C (en) * 1985-08-05 1991-12-31 Alan Purdom Carpenter Jr Metal-isonitrile adducts for preparing radionuclide complexes
US4894445A (en) * 1985-08-05 1990-01-16 E. I. Du Pont De Nemours And Company Metal-isonitrile adducts for preparing radionuclide complexes
US5155216A (en) * 1985-08-15 1992-10-13 Amoco Corporation Nucleic acids labeled with a chemiluminescent acridine ester
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
JP3293820B2 (ja) * 1985-12-13 2002-06-17 エンゾ− バイオケム インコ−ポレイテツド 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物
US4831122A (en) * 1986-01-09 1989-05-16 Regents Of The University Of Minnesota Radioimmunotoxins
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
GB8610551D0 (en) * 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
US6673347B1 (en) * 1986-04-30 2004-01-06 Gryphon Therapeutics Polypeptide and protein derivatives and process for their preparation
US5011959A (en) * 1986-11-17 1991-04-30 The Board Of Regents, The University Of Texas System 1,2-diaminocyclohexane-platinum complexes with antitumor activity
AU619218B2 (en) * 1987-11-06 1992-01-23 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
WO1989005853A1 (en) * 1987-12-15 1989-06-29 Synthetic Genetics Nucleic acid chelate conjugate as therapeutic and diagnostic agents
EP0325559B1 (de) * 1988-01-20 1993-12-15 Ciba-Geigy Ag Verfahren zur Herstellung von Komplexverbindungen
US6326136B1 (en) 1988-04-01 2001-12-04 Digene Corporation Macromolecular conjugate made using unsaturated aldehydes
WO1989009780A1 (en) * 1988-04-15 1989-10-19 Chemical Industry Institute Of Toxicology Site-specific tritium-labeled oligodeoxynucleotides
DE58905660D1 (de) * 1988-04-25 1993-10-28 Hoffmann La Roche Diagnose-Hilfsmittel.
US5059541A (en) * 1988-04-29 1991-10-22 Neorx Corporation Minimal derivatization of proteins
US4917878A (en) * 1988-05-02 1990-04-17 Thomas Jefferson University Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals
US5362473A (en) * 1988-10-14 1994-11-08 Mallinckrodt Medical, Inc. Radiolabelled particulate composition
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
GR1002475B (el) * 1988-12-05 1996-11-26 Novartis Ag (Novartis Sa) (Novartis Inc.) Μεθοδος παρασκευης πεπτιδικων παραγωγων.
US5612019A (en) * 1988-12-19 1997-03-18 Gordon, Deceased; David Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles
US5998135A (en) 1989-02-24 1999-12-07 Enzo Diagnostics, Inc. Energy transfer hybridization assay using intercalators and lanthanide metals
US5244816A (en) * 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
AU654663B2 (en) * 1989-11-30 1994-11-17 Mallinckrodt Medical, Inc. Method for preparing a metal-radionuclide-labelled protein
US5264343A (en) * 1990-08-31 1993-11-23 Eleanor Roosevelt Institute Method for distinguishing normal and cancer cells
US5122363A (en) * 1990-12-07 1992-06-16 Board Of Regents, The University Of Texas System Zeolite-enclosed transistion and rare earth metal ions as contrast agents for the gastrointestinal tract
US5578704A (en) * 1992-04-03 1996-11-26 Genentech, Inc. Antibody to osteoclast alphavbeta3 ntegrin
US5292938A (en) * 1992-04-13 1994-03-08 Associated Universities, Inc. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
US5279937A (en) * 1992-04-30 1994-01-18 Detechnology Canada Use of macroglobulins to improve the signal-to-background ratio in affinity binding assays
US7713528B1 (en) 1993-02-18 2010-05-11 Enzo Therapeutics, Inc. Method for in vivo delivery of active compounds using reagent conjugate
US6174530B1 (en) 1993-05-05 2001-01-16 Gryphon Sciences Homogeneous polyoxime compositions and their preparation by parallel assembly
DE69423753T2 (de) 1993-05-05 2000-11-02 Keith Rose Polyoximverbindungen und deren herstellung
US6001364A (en) 1993-05-05 1999-12-14 Gryphon Sciences Hetero-polyoxime compounds and their preparation by parallel assembly
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5705143A (en) * 1994-01-12 1998-01-06 Amersham International Plc Biological targeting agents
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
WO1996015653A2 (en) * 1994-11-04 1996-05-30 The Immune Response Corporation Vial retainer
US5648268A (en) * 1994-12-06 1997-07-15 Ibm Corporation Radionuclide exchange detection of ultra trace ionic impurities in water
US20050025740A1 (en) * 1996-01-05 2005-02-03 Keith Rose Polyoxime compounds and their preparation
US6736769B2 (en) 1996-04-17 2004-05-18 Olivier Bertrand Radioactivity local delivery system
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7393645B2 (en) * 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7090804B2 (en) 1998-01-27 2006-08-15 Clinical Mirco Sensors, Inc. Amplification of nucleic acids with electronic detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6214301B1 (en) 1998-03-27 2001-04-10 The Regents Of The University Of California Hafnium radioisotope recovery from irradiated tantalum
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
AU1241000A (en) * 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
WO2001007665A2 (en) 1999-07-26 2001-02-01 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
WO2007128873A1 (en) * 2006-05-05 2007-11-15 Wallac Oy A method for the preparation of maleimido derivatives of biomolecule labeling reactants and conjugates derived thereof
US8150101B2 (en) 2006-11-13 2012-04-03 Cybernet Systems Corporation Orientation invariant object identification using model-based image processing
DE102007002726A1 (de) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
WO2009124150A2 (en) 2008-04-01 2009-10-08 Biosearch Technologies, Inc. Stabilized nucleic acid dark quencher-fluorophore probes
US10519485B2 (en) 2015-04-15 2019-12-31 Biosearch Technologies, Inc. Dual quencher probes
WO2023018805A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Methods and related aspects of detecting and purifying influenza neuraminidase

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3936440A (en) * 1974-05-22 1976-02-03 Drexel University Method of labeling complex metal chelates with radioactive metal isotopes
FR2281134A1 (fr) * 1974-08-06 1976-03-05 Commissariat Energie Atomique Procede de marquage au 99m technetium
US4043998A (en) * 1974-10-09 1977-08-23 The Board Of Trustees Of The Leland Stanford Junior University 1-(P-benzenediazonium)-ethylenediamine tetraacetic acid
US4272503A (en) * 1978-05-25 1981-06-09 New England Nuclear Corporation Reductant composition for technetium-99m and method for making technetium-99m labelled ligands
US4305922A (en) * 1978-10-04 1981-12-15 University Patents, Inc. Labeling proteins with 99m-Tc by ligand exchange
US4320109A (en) * 1979-06-29 1982-03-16 The University Of Southern California Immunoradiometric assay employing terminal radionuclide labeling and synthesis of conjugates for such assay
US4385046A (en) * 1980-12-15 1983-05-24 Minnesota Mining And Manufacturing Company Diagnostic radio-labeled polysaccharide derivatives
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
CA1225930A (en) * 1982-06-07 1987-08-25 Otto A. Gansow Metal chelate conjugated monoclonal antibodies
US4479930A (en) * 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
JPS59199636A (ja) * 1983-04-26 1984-11-12 Nippon Mejifuijitsukusu Kk 放射性診断剤
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels

Also Published As

Publication number Publication date
NO850353L (no) 1985-07-31
ATE92190T1 (de) 1993-08-15
US4707352A (en) 1987-11-17
JPS60178827A (ja) 1985-09-12
CA1256023A (en) 1989-06-20
DE3587477T2 (de) 1994-02-17
US4767609A (en) 1988-08-30
DE3587477D1 (de) 1993-09-02
EP0150844B1 (en) 1993-07-28
EP0150844A2 (en) 1985-08-07
AU3821385A (en) 1985-08-08
IL74187A0 (en) 1985-04-30
US4772548A (en) 1988-09-20
ES539927A0 (es) 1987-03-01
JPH0822822B2 (ja) 1996-03-06
IL74187A (en) 1989-03-31
DK39985A (da) 1985-07-31
EP0150844A3 (en) 1988-05-04
AU597208B2 (en) 1990-05-24
DK39985D0 (da) 1985-01-29

Similar Documents

Publication Publication Date Title
ES8704001A1 (es) Un metodo de marcar un agente terapeutico o diagnostico con un ion de metal radiactivo
EP0193561A4 (en) MONOCLONAL ANTIBODIES AGAINST METAL CHELATES.
EP0174853A3 (en) Radiolabeled antibody fragments
IL94690A0 (en) Method and kit for radiolabeling using technetium
AU4845185A (en) Coupling agents for radiolabeled antibody fragments
EP0038546A3 (en) Radiolabeled diagnostic compositions and method for making the same
AU561671B2 (en) Process for phosphatizing iron and steel
EP0174641A3 (en) A process for recovering valuable metals from an iron dust containing a higher content of zinc
ES2035041T3 (es) Marcaje mediante iones metalicos de moleculas transportadoras.
ZA853556B (en) Fine granular desulfurizing agent for iron melts and process for desulfurizing pig-iron melts
GB2125393B (en) Method of and composition for inhibiting corrosion of iron base metals
DE3260643D1 (en) Process for producing desulfurizing agents for pig iron and steel melts
GR3006837T3 (es)
ZA839054B (en) A method and an arrangement for producing metals,in particular molten pig iron,steel pre-material or ferroalloys
JPS6415134A (en) Scavenger for heavy metal such as composite radionuclide
EP0201923A3 (en) Method for coating solid bodies with lubricants
ZA851409B (en) Bis(aminomethyl)bicyclo(2.2.1)heptanes useful as metal ion control agents and radioactive metals complexed therewith
DE3380120D1 (en) Process for producing corrosion-resistant alloy steel
DE3360636D1 (en) Direct reduction method for iron ores
Johannesmeyer et al. Fixation of heavy metals in electroplating wastes
IL74386A0 (en) Bis(aminomethyl)bicyclo(2,2,1)heptanes useful as metal ion control agents and radioactive metal complexed therewith
BG30703A2 (en) Method for chemical- thermal treating of metals and alloys, especially for animmonation
BG33517A1 (en) 1:2 metal containing complex of o, o'- dihydroxymonoazocompound and method for their obtaining
CS543287A1 (en) Process for introducing additional components-dopants-in quantity by 20% mass.in ammonium aluminium sulphate
PL235562A2 (en) Graphite-forming inoculant for iron alloys

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303