ES8703402A1 - Procedimiento para la obtencion de nuevos derivados del acido benzoico - Google Patents

Procedimiento para la obtencion de nuevos derivados del acido benzoico

Info

Publication number
ES8703402A1
ES8703402A1 ES553731A ES553731A ES8703402A1 ES 8703402 A1 ES8703402 A1 ES 8703402A1 ES 553731 A ES553731 A ES 553731A ES 553731 A ES553731 A ES 553731A ES 8703402 A1 ES8703402 A1 ES 8703402A1
Authority
ES
Spain
Prior art keywords
pharmaceutical preparations
compounds
represent
acid derivatives
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553731A
Other languages
English (en)
Other versions
ES553731A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of ES553731A0 publication Critical patent/ES553731A0/es
Publication of ES8703402A1 publication Critical patent/ES8703402A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring

Abstract

PROCEDIMOIENTO PARA LA OBTENCION DE NUEVOS DERIVADOS DEL ACIDO BENZOICO, ASI COMO SUS SALES FARMACEUTICAMENTE COMPATIBLES DE ESTOS ESTERES BASICOS CON ACIDOS. CONSISTE EN HACER REACCIONAR A UNA TEMPERATURA COMPRENDIDA ENTRE C80 Y 50 GRADOS EN UN DISOLVENTE APROTICO, ESPECIALMENTE EN UN DISOLVENTE DIPOLAR APROTICO, Y EN PRESENCIA DE CANTIDADES CATALITICAS DE UNA SAL DE COBRE, UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE A Y E SIGNIFICAN -CFC-; B Y D SIGNIFICAN -CH2-CH2-; R1 SIGNIFICA HIDROGENO, METILO O ETILO; R2 SIGNIFICA HIDROGENO O UN RESTO ALQUILO DE CADENA LINEAL CON 1 A 6 ATOMOS DE CARBONO; R11 REPRESENTA UN GRUPO PROTECTOR DESDOBLABLE; Y R12 SIGNIFICA UN ATOMO DE BROMO O DE YODO, CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE ME REPRESENTA UN ATOMO DE LITIO. DE APLICACION EN TERAPEUTICA.
ES553731A 1985-04-27 1986-04-04 Procedimiento para la obtencion de nuevos derivados del acido benzoico Expired ES8703402A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853515278 DE3515278A1 (de) 1985-04-27 1985-04-27 Neue benzoesaeurederivate, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel

Publications (2)

Publication Number Publication Date
ES553731A0 ES553731A0 (es) 1987-02-16
ES8703402A1 true ES8703402A1 (es) 1987-02-16

Family

ID=6269293

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553731A Expired ES8703402A1 (es) 1985-04-27 1986-04-04 Procedimiento para la obtencion de nuevos derivados del acido benzoico

Country Status (15)

Country Link
EP (1) EP0199985A3 (es)
JP (1) JPS6242947A (es)
KR (1) KR860008155A (es)
AU (1) AU582433B2 (es)
DD (1) DD250313A5 (es)
DE (1) DE3515278A1 (es)
DK (1) DK186286A (es)
ES (1) ES8703402A1 (es)
FI (1) FI861414A (es)
GR (1) GR860442B (es)
HU (1) HU196163B (es)
IL (1) IL77989A (es)
PT (1) PT82393B (es)
SU (1) SU1450734A3 (es)
ZA (1) ZA861490B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2642972B1 (fr) * 1989-02-14 1994-08-05 Inst Nat Sante Rech Med Agents pour le diagnostic et le traitement des melanomes, derives halogenes aromatiques utilisables comme de tels agents et leur preparation
DE4023742A1 (de) * 1990-07-26 1992-01-30 Gruenenthal Gmbh Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
DE4120698A1 (de) * 1991-06-22 1992-12-24 Gruenenthal Gmbh Substituierte phenoxyalkanole und deren ester, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8106124A1 (es) * 1979-09-05 1981-07-16 Glaxo Group Ltd Un procedimiento para la pre-paracion de fenoxialcoxifenil- derivados.
US4331683A (en) * 1980-10-29 1982-05-25 Pfizer Inc. Carboxamide compounds as SRS-A antagonists
EP0056172B1 (en) * 1981-01-09 1985-04-03 FISONS plc Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them
US4499299A (en) * 1981-12-30 1985-02-12 Ici Americas Inc. Pharmaceutically active phenylcarboxylic acid derivatives
US4507498A (en) * 1982-04-09 1985-03-26 Hoffmann-La Roche Inc. Phenoxycarboxylic acids
DE3228629A1 (de) * 1982-07-31 1984-02-02 Reifenrath, Rainer Richard Otto, Dr., 3104 Unterlüß Pharmazeutisches erzeugnis zur behandlung der atemwege und verfahren zu seiner herstellung
IL69691A (en) * 1982-09-23 1988-01-31 Merck Frosst Canada Inc Leukotriene antagonists,their preparation and pharmaceutical compositions containing them
DD242802A1 (de) * 1983-02-28 1987-02-11 Univ Berlin Humboldt Verfahren zur herstellung neuer w(2'-naphthoxy)-hydroxamsaeuren enthaltende pharmazeutische zubereitungen und ihren salzen
US4539419A (en) * 1983-05-02 1985-09-03 Hoffmann-La Roche Inc. Naphthalenyloxy substituted carboxylic acids
US4499295A (en) * 1983-05-09 1985-02-12 G. D. Searle & Co. Protease inhibitors

Also Published As

Publication number Publication date
DK186286A (da) 1986-10-28
DD250313A5 (de) 1987-10-08
AU5636686A (en) 1986-11-06
ES553731A0 (es) 1987-02-16
HUT40611A (en) 1987-01-28
GR860442B (en) 1986-06-16
DE3515278A1 (de) 1986-10-30
HU196163B (en) 1988-10-28
FI861414A0 (fi) 1986-04-01
IL77989A (en) 1989-08-15
AU582433B2 (en) 1989-03-23
EP0199985A2 (de) 1986-11-05
FI861414A (fi) 1986-10-28
KR860008155A (ko) 1986-11-12
ZA861490B (en) 1986-10-29
DK186286D0 (da) 1986-04-23
SU1450734A3 (ru) 1989-01-07
EP0199985A3 (de) 1988-06-22
PT82393A (de) 1986-05-01
JPS6242947A (ja) 1987-02-24
PT82393B (de) 1987-09-10

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