ES8701765A1 - Procedimiento para la obtencion de acido (5,r 6s)-2-aminome-til-6-(1r)-1-hidroxietil -2-penem-3-carboxilico cristalino - Google Patents

Procedimiento para la obtencion de acido (5,r 6s)-2-aminome-til-6-(1r)-1-hidroxietil -2-penem-3-carboxilico cristalino

Info

Publication number
ES8701765A1
ES8701765A1 ES548435A ES548435A ES8701765A1 ES 8701765 A1 ES8701765 A1 ES 8701765A1 ES 548435 A ES548435 A ES 548435A ES 548435 A ES548435 A ES 548435A ES 8701765 A1 ES8701765 A1 ES 8701765A1
Authority
ES
Spain
Prior art keywords
crystalline
aminomethyl compound
aminomethyl
compound
penem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548435A
Other languages
English (en)
Other versions
ES548435A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8701765A1 publication Critical patent/ES8701765A1/es
Publication of ES548435A0 publication Critical patent/ES548435A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO (5R,6S)-2-AMINOMETIL-6-(1R)-1-HIDROXIETIL-PENEM-3-CARBOXILICO EN FORMA CRISTALINA Y PREPARADOS FARMACEUTICOSA QUE LO CONTENGAN. CONSISTE EN OBTENER EL PRODUCTO CRISTALINO A PARTIR DE UNA SOLUCION SOBRESATURADA EN UN DISOLVENTE ORGANICO QUE CONTENGA AGUA. EL PRODUCTO POSTERIORMENTE SE AISLA Y SE SECA. SE EMPLEA COMO ANTIBIOTICO ANTIBACTERIAL DE APLICACION PARENTERAL PARA EL TRATAMIENTO DE INFECCIONES.
ES548435A 1984-11-02 1985-10-31 Procedimiento para la obtencion de acido (5,r 6s)-2-aminome-til-6-(1r)-1-hidroxietil -2-penem-3-carboxilico cristalino Expired ES8701765A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH526684 1984-11-02

Publications (2)

Publication Number Publication Date
ES8701765A1 true ES8701765A1 (es) 1986-12-01
ES548435A0 ES548435A0 (es) 1986-12-01

Family

ID=4290719

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548435A Expired ES8701765A1 (es) 1984-11-02 1985-10-31 Procedimiento para la obtencion de acido (5,r 6s)-2-aminome-til-6-(1r)-1-hidroxietil -2-penem-3-carboxilico cristalino

Country Status (17)

Country Link
US (1) US4761408A (es)
EP (1) EP0181571A1 (es)
JP (1) JPS61165390A (es)
KR (1) KR890001009B1 (es)
AU (1) AU580636B2 (es)
DD (1) DD242408A5 (es)
DK (1) DK505485A (es)
ES (1) ES8701765A1 (es)
FI (1) FI854268A (es)
GR (1) GR852625B (es)
HU (1) HUT39184A (es)
IL (1) IL76897A (es)
NO (1) NO854364L (es)
NZ (1) NZ214046A (es)
PH (1) PH23259A (es)
PT (1) PT81411B (es)
ZA (1) ZA858402B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243921A3 (de) * 1986-04-29 1987-12-16 Ciba-Geigy Ag Kristallines Hydrat eines Penem-Derivats
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
GB8818789D0 (en) * 1988-08-08 1988-09-07 Erba Carlo Spa Crystalline(5r 6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penem-carboxylic acid & pharmaceutical formulation
CA2354558A1 (en) * 1999-10-12 2001-04-19 Suntory Limited Oral pharmaceutical composition
US20040202714A1 (en) * 1999-10-12 2004-10-14 Daiichi Suntory Pharma Co., Ltd. Oral pharmaceutical composition

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
GB2043639B (en) * 1979-02-24 1983-07-20 Erba Farmitalia 3-optionally substituted methyl-2-penem derivatives
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
EP0070204B1 (en) * 1981-07-15 1987-11-19 Sumitomo Pharmaceuticals Company, Limited Carboxylic beta-lactam compounds and the preparation thereof
US4540580A (en) * 1982-11-16 1985-09-10 Schering Corporation 2-[(1'R)-1'-Aminoalkyl]penems
EP0125208A1 (de) * 1983-05-06 1984-11-14 Ciba-Geigy Ag Aminoniederalkyl-penem-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
EP0132101A1 (en) * 1983-07-14 1985-01-23 Pfizer Inc. 2-Heterocycloalkylthiopenem derivatives
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4634556A (en) * 1985-05-10 1987-01-06 Schering Corporation Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same

Also Published As

Publication number Publication date
PH23259A (en) 1989-06-16
HUT39184A (en) 1986-08-28
PT81411A (en) 1985-11-01
IL76897A (en) 1989-10-31
DD242408A5 (de) 1987-01-28
FI854268A (fi) 1986-05-03
FI854268A0 (fi) 1985-10-30
GR852625B (es) 1986-03-03
DK505485D0 (da) 1985-11-01
IL76897A0 (en) 1986-02-28
KR860004064A (ko) 1986-06-16
DK505485A (da) 1986-05-03
KR890001009B1 (ko) 1989-04-18
JPS61165390A (ja) 1986-07-26
US4761408A (en) 1988-08-02
ZA858402B (en) 1986-06-25
AU4930685A (en) 1986-05-08
PT81411B (en) 1987-08-04
ES548435A0 (es) 1986-12-01
AU580636B2 (en) 1989-01-19
NZ214046A (en) 1988-09-29
EP0181571A1 (de) 1986-05-21
NO854364L (no) 1986-05-05

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