ES8701196A1 - Un procedimiento para la preparacion de dipeptidos derivados de tiazolina. - Google Patents
Un procedimiento para la preparacion de dipeptidos derivados de tiazolina.Info
- Publication number
- ES8701196A1 ES8701196A1 ES548530A ES548530A ES8701196A1 ES 8701196 A1 ES8701196 A1 ES 8701196A1 ES 548530 A ES548530 A ES 548530A ES 548530 A ES548530 A ES 548530A ES 8701196 A1 ES8701196 A1 ES 8701196A1
- Authority
- ES
- Spain
- Prior art keywords
- compositions containing
- pharmaceutical activity
- alanine
- group
- dipeptide compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 108010016626 Dipeptides Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 2
- 229960003180 glutathione Drugs 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 108010024636 Glutathione Proteins 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- 229940000635 beta-alanine Drugs 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 238000009109 curative therapy Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DIPEPTIDOS DERIVADOS DE TIAZOLIDINA DE FORMULA GENERAL (I). CONSISTE EN CONDENSAR EL ACIDO 2-METIL-TIAZOLIDIN-4-CARBOXILICO, PROTEGIDO ADECUADAMENTE EN EL ATOMO DE NITROGENO, CON UN ESTER DEL AMINOACIDO ELEGIDO, EN PRESENCIA DE UN AGENTE DE COPULACION. ELIMINANDO EL GRUPO PROTECTOR SE OBTIENEN LOS ESTERES DE LA FORMULA (I) Y DE ESTOS, LOS ACIDOS LIBRES, POR HIDROLISIS. SE USAN EN TRATAMIENTO DE SINDROMES PATOLOGICOS DERIVADOS DE NIVELES BAJOS DE GLUTATIONA INTRACELULAR (GSH).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT23173/84A IT1176983B (it) | 1984-10-16 | 1984-10-16 | Dipeptidi ad attivita' farmacologica |
Publications (2)
Publication Number | Publication Date |
---|---|
ES548530A0 ES548530A0 (es) | 1986-11-16 |
ES8701196A1 true ES8701196A1 (es) | 1986-11-16 |
Family
ID=11204532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES548530A Expired ES8701196A1 (es) | 1984-10-16 | 1985-10-15 | Un procedimiento para la preparacion de dipeptidos derivados de tiazolina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4761399A (es) |
EP (1) | EP0198898B1 (es) |
JP (1) | JPS62500871A (es) |
AU (1) | AU582600B2 (es) |
CA (1) | CA1262550A (es) |
DK (1) | DK269186A (es) |
ES (1) | ES8701196A1 (es) |
FI (1) | FI84836C (es) |
IT (1) | IT1176983B (es) |
WO (1) | WO1986002353A1 (es) |
ZA (1) | ZA857912B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1196485B (it) * | 1986-07-14 | 1988-11-16 | Zambon Spa | Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica |
DE3818850A1 (de) * | 1988-06-03 | 1989-12-07 | Hoechst Ag | Oligopeptide mit zyklischen prolin-analogen aminosaeuren |
EP0486621A4 (en) * | 1989-08-09 | 1993-03-31 | The Children's Medical Center Corporation | Nmda oxidizing agents for protecting neurons from injury |
US5238683A (en) * | 1989-11-24 | 1993-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs |
US5977073A (en) * | 1991-06-06 | 1999-11-02 | Life Sciences' Technologies, Inc. | Nutrient composition for treatment of immune disorders |
AU661379B2 (en) * | 1992-04-23 | 1995-07-20 | Transcend Therapeutics, Inc | Method of reducing or preventing toxicity associated with antiretroviral therapy |
US5618823A (en) * | 1992-06-24 | 1997-04-08 | Boehringer Mannheim Italia S.P.A. | Glutathione as chemoprotective agent |
ES2052454B1 (es) * | 1992-12-31 | 1995-01-16 | Zambon S A | Dipeptidos y composiciones que los contienen con accion farmaceutica contra el envejecimiento. |
US6251857B1 (en) | 1995-12-14 | 2001-06-26 | Novelos Therapeutics, Inc. | Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof |
RU2089179C1 (ru) * | 1995-12-14 | 1997-09-10 | Закрытое акционерное общество "ВАМ" | Стимулятор эндогенной продукции цитокинов и гепопоэтических факторов и способ его использования |
US5965596A (en) | 1997-08-12 | 1999-10-12 | Harris; Roger | Methods and compositions for increasing the anaerobic working capacity in tissue |
US7504376B2 (en) | 1996-08-12 | 2009-03-17 | Natural Alternatives International | Methods and compositions for increasing the anaerobic working capacity in tissues |
AU7667498A (en) * | 1997-05-30 | 1998-12-30 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
AU3260399A (en) | 1998-02-26 | 1999-09-15 | Celltech Therapeutics Limited | Phenylalanine derivatives as inhibitors of alpha4 integrins |
GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
US20070142267A1 (en) * | 1998-11-23 | 2007-06-21 | Novelos Therapeutics, Inc. | Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells |
RU2144374C1 (ru) | 1998-11-23 | 2000-01-20 | Закрытое акционерное общество "ВАМ" | Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
EP1332132B1 (en) | 2000-04-17 | 2007-10-10 | UCB Pharma, S.A. | Enamine derivatives as cell adhesion molecules |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6740654B2 (en) | 2000-07-07 | 2004-05-25 | Celltech R & D Limited | Squaric acid derivatives |
EP1305291A1 (en) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
WO2006101910A2 (en) * | 2005-03-16 | 2006-09-28 | Ischemix, Inc. | Peptide compounds and methods of using peptide compounds to treat conditions affecting the cardiac, pulmonary, and nervous systems |
WO2007073398A2 (en) | 2005-05-23 | 2007-06-28 | Natural Alternatives International | Compositions and methods for the sustained release of beta-alanine |
US20110064828A1 (en) * | 2009-09-11 | 2011-03-17 | Novelos Therapeutics, Incorporated | Treatment of metastatic tumors and other conditions |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
GR75019B (es) * | 1980-09-17 | 1984-07-12 | Univ Miami | |
DE3174844D1 (en) * | 1980-10-23 | 1986-07-24 | Schering Corp | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
DE3332633A1 (de) * | 1983-09-09 | 1985-04-04 | Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München | Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel |
-
1984
- 1984-10-16 IT IT23173/84A patent/IT1176983B/it active
-
1985
- 1985-10-15 ES ES548530A patent/ES8701196A1/es not_active Expired
- 1985-10-15 ZA ZA857912A patent/ZA857912B/xx unknown
- 1985-10-16 EP EP85905404A patent/EP0198898B1/en not_active Expired
- 1985-10-16 JP JP60504955A patent/JPS62500871A/ja active Pending
- 1985-10-16 AU AU50165/85A patent/AU582600B2/en not_active Ceased
- 1985-10-16 US US06/874,179 patent/US4761399A/en not_active Expired - Lifetime
- 1985-10-16 CA CA000493120A patent/CA1262550A/en not_active Expired
- 1985-10-16 WO PCT/EP1985/000543 patent/WO1986002353A1/en active IP Right Grant
-
1986
- 1986-04-01 FI FI861383A patent/FI84836C/fi not_active IP Right Cessation
- 1986-06-09 DK DK269186A patent/DK269186A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES548530A0 (es) | 1986-11-16 |
AU5016585A (en) | 1986-05-02 |
DK269186D0 (da) | 1986-06-09 |
WO1986002353A1 (en) | 1986-04-24 |
IT8423173A0 (it) | 1984-10-16 |
FI84836B (fi) | 1991-10-15 |
CA1262550A (en) | 1989-10-31 |
EP0198898A1 (en) | 1986-10-29 |
EP0198898B1 (en) | 1988-08-24 |
FI84836C (fi) | 1992-01-27 |
ZA857912B (en) | 1986-05-28 |
FI861383A0 (fi) | 1986-04-01 |
JPS62500871A (ja) | 1987-04-09 |
IT1176983B (it) | 1987-08-26 |
US4761399A (en) | 1988-08-02 |
DK269186A (da) | 1986-06-09 |
FI861383A (fi) | 1986-04-17 |
AU582600B2 (en) | 1989-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |