ES8701153A1 - Procedimiento de preparar derivados 7-oxo-prostaciclinicos - Google Patents

Procedimiento de preparar derivados 7-oxo-prostaciclinicos

Info

Publication number
ES8701153A1
ES8701153A1 ES549967A ES549967A ES8701153A1 ES 8701153 A1 ES8701153 A1 ES 8701153A1 ES 549967 A ES549967 A ES 549967A ES 549967 A ES549967 A ES 549967A ES 8701153 A1 ES8701153 A1 ES 8701153A1
Authority
ES
Spain
Prior art keywords
compounds
racemic
oxo
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549967A
Other languages
English (en)
Other versions
ES549967A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES8701153A1 publication Critical patent/ES8701153A1/es
Publication of ES549967A0 publication Critical patent/ES549967A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 7-OXOPROSTACICLINICOS, RACEMICOS U OPTICAMENTE ACTIVOS, DE FORMULA (I). COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LAS QUE A, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 2-4. LA OXIDACION SE LLEVA A CABO POR TRATAMIENTO DEL COMPUESTO DE FORMULA (II) CON 1,1 A 10 EQUIVALENTES DE DIOXIDO DE SELENIO, EN UN DISOLVENTE ORGANICO ANHIDRO, TAL COMO DIOXANO, A UNA TEMPERATURA COMPRENDIDA ENTRE 80JC Y 90JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES PERIFERICAS DE LOS VASOS Y PARA MEJORA DE LA CIRCULACION.
ES549967A 1984-01-13 1985-12-16 Procedimiento de preparar derivados 7-oxo-prostaciclinicos Expired ES8701153A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU84128A HU191264B (en) 1984-01-13 1984-01-13 Process for production of derivatives of 7-oxo-prostacyclin with selective biological effect

Publications (2)

Publication Number Publication Date
ES8701153A1 true ES8701153A1 (es) 1986-12-01
ES549967A0 ES549967A0 (es) 1986-12-01

Family

ID=10948057

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539474A Expired ES8605229A1 (es) 1984-01-13 1985-01-11 Procedimiento de preparar derivados 7-oxoprostaciclinicos
ES549967A Expired ES8701153A1 (es) 1984-01-13 1985-12-16 Procedimiento de preparar derivados 7-oxo-prostaciclinicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES539474A Expired ES8605229A1 (es) 1984-01-13 1985-01-11 Procedimiento de preparar derivados 7-oxoprostaciclinicos

Country Status (12)

Country Link
US (1) US4588713A (es)
EP (1) EP0163905B1 (es)
JP (1) JPH0643413B2 (es)
AT (1) ATE40359T1 (es)
AU (1) AU576815B2 (es)
DK (1) DK165920C (es)
ES (2) ES8605229A1 (es)
FI (1) FI850123A0 (es)
GR (1) GR850078B (es)
HU (1) HU191264B (es)
IL (1) IL73945A (es)
SU (3) SU1376939A3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
US4330553A (en) * 1979-11-12 1982-05-18 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Oxo-PGI2 -derivatives and process for the preparation thereof and pharmaceutical compositions containing same
DE3035454A1 (de) * 1980-09-18 1982-04-22 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung
DE3308561A1 (de) * 1983-03-08 1984-09-13 Schering AG, 1000 Berlin und 4709 Bergkamen 19,20-methylenprostacyclinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
HU191264B (en) 1987-01-28
HUT35658A (en) 1985-07-29
JPS61243073A (ja) 1986-10-29
SU1424735A3 (ru) 1988-09-15
AU576815B2 (en) 1988-09-08
IL73945A (en) 1988-05-31
DK14985D0 (da) 1985-01-11
GR850078B (es) 1985-05-13
EP0163905B1 (de) 1989-01-25
DK14985A (da) 1985-07-14
IL73945A0 (en) 1985-03-31
ES549967A0 (es) 1986-12-01
ES539474A0 (es) 1986-04-01
ATE40359T1 (de) 1989-02-15
AU3762485A (en) 1985-07-18
US4588713A (en) 1986-05-13
ES8605229A1 (es) 1986-04-01
DK165920C (da) 1993-06-28
SU1376939A3 (ru) 1988-02-23
EP0163905A1 (de) 1985-12-11
SU1421741A1 (ru) 1988-09-07
JPH0643413B2 (ja) 1994-06-08
FI850123A0 (fi) 1985-01-11
DK165920B (da) 1993-02-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981001