ES8701153A1 - Procedimiento de preparar derivados 7-oxo-prostaciclinicos - Google Patents
Procedimiento de preparar derivados 7-oxo-prostaciclinicosInfo
- Publication number
- ES8701153A1 ES8701153A1 ES549967A ES549967A ES8701153A1 ES 8701153 A1 ES8701153 A1 ES 8701153A1 ES 549967 A ES549967 A ES 549967A ES 549967 A ES549967 A ES 549967A ES 8701153 A1 ES8701153 A1 ES 8701153A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- racemic
- oxo
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 7-OXOPROSTACICLINICOS, RACEMICOS U OPTICAMENTE ACTIVOS, DE FORMULA (I). COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LAS QUE A, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 2-4. LA OXIDACION SE LLEVA A CABO POR TRATAMIENTO DEL COMPUESTO DE FORMULA (II) CON 1,1 A 10 EQUIVALENTES DE DIOXIDO DE SELENIO, EN UN DISOLVENTE ORGANICO ANHIDRO, TAL COMO DIOXANO, A UNA TEMPERATURA COMPRENDIDA ENTRE 80JC Y 90JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES PERIFERICAS DE LOS VASOS Y PARA MEJORA DE LA CIRCULACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU84128A HU191264B (en) | 1984-01-13 | 1984-01-13 | Process for production of derivatives of 7-oxo-prostacyclin with selective biological effect |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8701153A1 true ES8701153A1 (es) | 1986-12-01 |
| ES549967A0 ES549967A0 (es) | 1986-12-01 |
Family
ID=10948057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES539474A Expired ES8605229A1 (es) | 1984-01-13 | 1985-01-11 | Procedimiento de preparar derivados 7-oxoprostaciclinicos |
| ES549967A Expired ES8701153A1 (es) | 1984-01-13 | 1985-12-16 | Procedimiento de preparar derivados 7-oxo-prostaciclinicos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES539474A Expired ES8605229A1 (es) | 1984-01-13 | 1985-01-11 | Procedimiento de preparar derivados 7-oxoprostaciclinicos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4588713A (es) |
| EP (1) | EP0163905B1 (es) |
| JP (1) | JPH0643413B2 (es) |
| AT (1) | ATE40359T1 (es) |
| AU (1) | AU576815B2 (es) |
| DK (1) | DK165920C (es) |
| ES (2) | ES8605229A1 (es) |
| FI (1) | FI850123A0 (es) |
| GR (1) | GR850078B (es) |
| HU (1) | HU191264B (es) |
| IL (1) | IL73945A (es) |
| SU (3) | SU1376939A3 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU197733B (en) * | 1985-05-29 | 1989-05-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives |
| US4808734A (en) * | 1986-12-01 | 1989-02-28 | Hoffmann-La Roche Inc. | 16-cycloalkyl-7-fluoro-prostacyclins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178367A (en) * | 1977-02-21 | 1979-12-11 | Ono Pharmaceutical Co. Ltd. | Prostaglandin I2 analogues |
| US4330553A (en) * | 1979-11-12 | 1982-05-18 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | 7-Oxo-PGI2 -derivatives and process for the preparation thereof and pharmaceutical compositions containing same |
| DE3035454A1 (de) * | 1980-09-18 | 1982-04-22 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung |
| DE3308561A1 (de) * | 1983-03-08 | 1984-09-13 | Schering AG, 1000 Berlin und 4709 Bergkamen | 19,20-methylenprostacyclinderivate und verfahren zu ihrer herstellung |
-
1984
- 1984-01-13 HU HU84128A patent/HU191264B/hu not_active IP Right Cessation
- 1984-12-27 IL IL73945A patent/IL73945A/xx not_active IP Right Cessation
-
1985
- 1985-01-11 GR GR850078A patent/GR850078B/el unknown
- 1985-01-11 AU AU37624/85A patent/AU576815B2/en not_active Ceased
- 1985-01-11 ES ES539474A patent/ES8605229A1/es not_active Expired
- 1985-01-11 DK DK014985A patent/DK165920C/da not_active IP Right Cessation
- 1985-01-11 EP EP85104957A patent/EP0163905B1/de not_active Expired
- 1985-01-11 SU SU853837051A patent/SU1376939A3/ru active
- 1985-01-11 AT AT85104957T patent/ATE40359T1/de not_active IP Right Cessation
- 1985-01-11 FI FI850123A patent/FI850123A0/fi not_active Application Discontinuation
- 1985-01-14 US US06/691,340 patent/US4588713A/en not_active Expired - Fee Related
- 1985-04-18 JP JP60081510A patent/JPH0643413B2/ja not_active Expired - Lifetime
- 1985-06-13 SU SU853912355A patent/SU1421741A1/ru active
- 1985-12-16 ES ES549967A patent/ES8701153A1/es not_active Expired
-
1986
- 1986-01-17 SU SU864008367A patent/SU1424735A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| HU191264B (en) | 1987-01-28 |
| HUT35658A (en) | 1985-07-29 |
| JPS61243073A (ja) | 1986-10-29 |
| SU1424735A3 (ru) | 1988-09-15 |
| AU576815B2 (en) | 1988-09-08 |
| IL73945A (en) | 1988-05-31 |
| DK14985D0 (da) | 1985-01-11 |
| GR850078B (es) | 1985-05-13 |
| EP0163905B1 (de) | 1989-01-25 |
| DK14985A (da) | 1985-07-14 |
| IL73945A0 (en) | 1985-03-31 |
| ES549967A0 (es) | 1986-12-01 |
| ES539474A0 (es) | 1986-04-01 |
| ATE40359T1 (de) | 1989-02-15 |
| AU3762485A (en) | 1985-07-18 |
| US4588713A (en) | 1986-05-13 |
| ES8605229A1 (es) | 1986-04-01 |
| DK165920C (da) | 1993-06-28 |
| SU1376939A3 (ru) | 1988-02-23 |
| EP0163905A1 (de) | 1985-12-11 |
| SU1421741A1 (ru) | 1988-09-07 |
| JPH0643413B2 (ja) | 1994-06-08 |
| FI850123A0 (fi) | 1985-01-11 |
| DK165920B (da) | 1993-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981001 |