ES8609275A1 - Un procedimiento para preparar un derivado de pirimidina - Google Patents

Un procedimiento para preparar un derivado de pirimidina

Info

Publication number
ES8609275A1
ES8609275A1 ES543047A ES543047A ES8609275A1 ES 8609275 A1 ES8609275 A1 ES 8609275A1 ES 543047 A ES543047 A ES 543047A ES 543047 A ES543047 A ES 543047A ES 8609275 A1 ES8609275 A1 ES 8609275A1
Authority
ES
Spain
Prior art keywords
alkyl
aryl
significance
phenyl
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543047A
Other languages
English (en)
Spanish (es)
Other versions
ES543047A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848412184A external-priority patent/GB8412184D0/en
Priority claimed from GB858500417A external-priority patent/GB8500417D0/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of ES543047A0 publication Critical patent/ES543047A0/es
Publication of ES8609275A1 publication Critical patent/ES8609275A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES543047A 1984-05-12 1985-05-10 Un procedimiento para preparar un derivado de pirimidina Expired ES8609275A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB848412184A GB8412184D0 (en) 1984-05-12 1984-05-12 Biologically active nitrogen heterocycles
GB858500417A GB8500417D0 (en) 1985-01-08 1985-01-08 Biologically active nitrogen heterocycles
EP85302902A EP0164204A1 (en) 1984-05-12 1985-04-25 Novel pharmaceutically useful pyrimidines

Publications (2)

Publication Number Publication Date
ES543047A0 ES543047A0 (es) 1986-07-16
ES8609275A1 true ES8609275A1 (es) 1986-07-16

Family

ID=26287736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543047A Expired ES8609275A1 (es) 1984-05-12 1985-05-10 Un procedimiento para preparar un derivado de pirimidina

Country Status (9)

Country Link
EP (1) EP0164204A1 (enExample)
AU (1) AU4227685A (enExample)
DK (1) DK203985A (enExample)
ES (1) ES8609275A1 (enExample)
FI (1) FI851837L (enExample)
GR (1) GR851131B (enExample)
IL (1) IL75147A0 (enExample)
NO (1) NO851877L (enExample)
PT (1) PT80432B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711888A (en) * 1985-07-24 1987-12-08 Pfizer Inc. Hydroxy and alkoxy pyrimidines
ATE135699T1 (de) † 1986-01-13 1996-04-15 American Cyanamid Co 4,5,6-substituierte 2-pyrimidinamine
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
US5064963A (en) * 1990-04-25 1991-11-12 American Cyanamid Company Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines
US5177079A (en) * 1991-01-31 1993-01-05 Warner-Lambert Company 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
US5248682A (en) * 1991-01-31 1993-09-28 Warner-Lambert Company 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
EP0569493A4 (en) * 1991-01-31 1993-11-24 Warner-Lambert Company Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines
US5270319A (en) * 1991-09-09 1993-12-14 Warner-Lambert Company 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents
US5196431A (en) * 1992-02-24 1993-03-23 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US5220025A (en) * 1992-02-24 1993-06-15 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US5276186A (en) * 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
US5543520A (en) * 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
PL179417B1 (en) * 1993-10-01 2000-09-29 Novartis Ag Pharmacologically active derivatives of pyridine and methods of obtaining them
JPH08503971A (ja) * 1993-10-01 1996-04-30 チバ−ガイギー アクチェンゲゼルシャフト ピリミジンアミン誘導体及びその調製のための方法
US6096748A (en) * 1996-03-13 2000-08-01 Smithkline Beecham Corporation Pyrimidine compounds useful in treating cytokine mediated diseases
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
IL151946A0 (en) 2000-03-29 2003-04-10 Cyclacel Ltd 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders
IL161662A0 (en) 2001-11-01 2004-09-27 Janssen Pharmaceutica Nv Heteroaryl amines as glycogen synthase kinase 3 beta inhibitors (gsk3 inhibitors)
PL368920A1 (en) * 2001-11-01 2005-04-04 Janssen Pharmaceutica N.V. Aminobenzamide derivatives as glycogen synthase kinase 3beta inhibitors
TW200302728A (en) 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
JP2007500179A (ja) 2003-07-30 2007-01-11 サイクラセル・リミテッド キナーゼ阻害剤としての２−アミノフェニル−４−フェニルピリミジン
EP1732541A4 (en) * 2004-04-07 2008-03-05 Takeda Pharmaceutical CYCLIC COMPOUNDS
MX2007002169A (es) 2004-08-27 2007-08-14 Cyclacel Ltd Inhibidores de cdk de purina y pirimidina y su uso para el tratamiento de enfermedades inmunes.
WO2007038669A2 (en) 2005-09-27 2007-04-05 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
GB0606774D0 (en) * 2006-04-03 2006-05-10 Novartis Ag Organic compounds
AU2008247668B2 (en) 2007-05-04 2013-01-10 Irm Llc Pyrimidine derivatives and compositions as c-kit and PDGFR kinase inhibitors
AU2008289135B2 (en) 2007-08-22 2012-02-23 Irm Llc 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
KR101218926B1 (ko) * 2007-08-22 2013-01-04 아이알엠 엘엘씨 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
EP2299823A1 (en) * 2008-05-19 2011-03-30 The University of Tennessee Research Foundation Pyrimidine non-classical cannabinoid compounds and related methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496179A (en) * 1967-10-11 1970-02-17 Pfizer & Co C 2-amino-3,4-dihydroquinazolines
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
CA961855A (en) * 1969-10-16 1975-01-28 Eli Lilly And Company Immunosuppressants and anti-viral agents
US3900476A (en) * 1973-05-17 1975-08-19 Upjohn Co 2(2'-pyrimidylamino)quinazolines and their preparation
US4010269A (en) * 1975-06-16 1977-03-01 The Upjohn Company Antiviral quinazoline compositions and methods of use
DE3220118A1 (de) * 1982-05-28 1983-12-01 Bayer Ag, 5090 Leverkusen Alkylenverbrueckte guanidinothiazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
IL75147A0 (en) 1985-09-29
NO851877L (no) 1985-11-13
EP0164204A1 (en) 1985-12-11
FI851837A0 (fi) 1985-05-09
AU4227685A (en) 1985-11-14
GR851131B (enExample) 1985-11-25
ES543047A0 (es) 1986-07-16
DK203985A (da) 1985-11-13
PT80432B (en) 1987-04-16
FI851837A7 (fi) 1985-11-13
FI851837L (fi) 1985-11-13
DK203985D0 (da) 1985-05-08
PT80432A (en) 1985-06-01

Similar Documents

Publication Publication Date Title
ES8609275A1 (es) Un procedimiento para preparar un derivado de pirimidina
DK204085D0 (da) Pyrazolderivater, deres fremstilling og farmaceutiske anvendelse
GB1132084A (en) Novel dihydroxy-pyrimidines
ES8404990A1 (es) Un procedimiento para la preparacion de derivados de prolina.
DK193584D0 (da) Naphthoquinonderivater
FR2337554A1 (fr) Nouveaux derives de la pyrazolidinedione
GB1290818A (enExample)
ES8602649A1 (es) Procedimiento para preparar 4-hidroximetil-pirrolidinonas substituidas en posicion 1
DK494482A (da) 2-imidazolylmethyl-2-phenyl-1,3-dioxolaner, fremgangsmaade til deres fremstilling samt deres anvendelse som fungicider
ES8604589A1 (es) Procedimiento para preparar nuevos derivados de imidazo (1,5-a) pirimidina
GB1269664A (en) Process for producing 1,4-benzodiazepine derivatives and their salts
IL69188A0 (en) Quinazoline derivatives,their preparation and their use against coccidiosis in poultry and animals
GB1458205A (en) Fused pyrimidin-4- 3h-ones as antiallergy agents
ES8606305A1 (es) Un procedimiento para la preparacion de nuevos derivados de triazina
ES461779A1 (es) Procedimiento para la preparacion de lariloxi-3-amino-3-pro-panoles.
ZA81269B (en) 2,3-dihydro-imidazo(1,2-b)pyridazine derivatives,their preparation and their use
ES8400384A1 (es) Procedimiento para la preparacion de derivados de carbaciclina.
ES335265A1 (es) Procedimiento para la obtencion de un herbicida.
GB1191039A (en) Benzimidazole Methanesulphonates
ES8703417A1 (es) Procedimiento para fabricar compuestos piperidinonicos eficaces en el tratamiento de cardiopatias
ES8602797A1 (es) Procedimiento para preparar 11-piperazinil-5h-imidazo(2, 1-c) (1, 4) benzodiazepinas
AU572241B2 (en) 2-n,n-dimethylaminoethyl substituted 1-imidazole derivatives
GB1298210A (en) Improvements in or relating to dihalo-pyridazine derivatives
ES2041214A1 (es) Procedimiento para la obtencion de derivados de nitrobenzaldehido.
DE1906194A1 (en) Antibiotic cephalosporin cpds.