ES8609206A1 - Butanol derivative - Google Patents
Butanol derivativeInfo
- Publication number
- ES8609206A1 ES8609206A1 ES85548416A ES548416A ES8609206A1 ES 8609206 A1 ES8609206 A1 ES 8609206A1 ES 85548416 A ES85548416 A ES 85548416A ES 548416 A ES548416 A ES 548416A ES 8609206 A1 ES8609206 A1 ES 8609206A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- give
- butanol
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:1,1-Diphenyl-4-isobutylamino-1-butanol of formula I and its salt. USE:It has a powerful antiarrhythmic action and is used for the circulatory system. It has low toxicity and is used by giving orally, locally or into tissues. PREPARATION:The reaction of a benzoylpropionic acid ester of formula II with, e.g., Grignard reagent gives a compound of formula III. Then, the product is allowed to react with isocutylamine in the presence or absence of an appropriate solvent such as xylene, preferably at 100-110 deg.C to give a compound of formula IV. The reduction of the compound of formula IV is effected using a metal hydride such as lithium aluminum hydride in a solvent at room temperature to 100 deg.C to give the compound of formula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08427829A GB2150134B (en) | 1983-11-21 | 1984-11-02 | Pharmaceutically active 1,1-diphenyl-4-isobutylamino-1-1butanol and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8609206A1 true ES8609206A1 (en) | 1986-09-01 |
| ES548416A0 ES548416A0 (en) | 1986-09-01 |
Family
ID=10569192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES85548416A Expired ES8609206A1 (en) | 1984-11-02 | 1985-10-31 | Butanol derivative |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS61143343A (en) |
| ES (1) | ES8609206A1 (en) |
-
1985
- 1985-10-22 JP JP23711885A patent/JPS61143343A/en active Granted
- 1985-10-31 ES ES85548416A patent/ES8609206A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH053868B2 (en) | 1993-01-18 |
| JPS61143343A (en) | 1986-07-01 |
| ES548416A0 (en) | 1986-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |