ES8608505A1 - Un procedimiento para preparar acidos (6,11-dihidro-11-oxo- dibenz(b,e,)oxepinil)pentanoicos - Google Patents

Un procedimiento para preparar acidos (6,11-dihidro-11-oxo- dibenz(b,e,)oxepinil)pentanoicos

Info

Publication number
ES8608505A1
ES8608505A1 ES542555A ES542555A ES8608505A1 ES 8608505 A1 ES8608505 A1 ES 8608505A1 ES 542555 A ES542555 A ES 542555A ES 542555 A ES542555 A ES 542555A ES 8608505 A1 ES8608505 A1 ES 8608505A1
Authority
ES
Spain
Prior art keywords
oxodibenz
oxepinyl
dihydro
intermediates
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542555A
Other languages
English (en)
Other versions
ES542555A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES8608505A1 publication Critical patent/ES8608505A1/es
Publication of ES542555A0 publication Critical patent/ES542555A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ACIDOS 6,11-DIHIDRO-11-OXODIBENZ(B,E)OXEPINILPENTANOICOS. CONSISTE EN CICLIZAR A UN C.D.F. (II), EN PRESENCIA DE UN AGENTE DESHIDRATANTE COMO ACIDO POLIFOSFORICO-ALCANOL O PENTOXIDO DE FOSFORO, ENTRE LA TEMPERATURA AMBIENTE Y 120JC Y EN SULFONAL, PARA OBTENER ACIDOS 6,11-DIHIDRO-11-OXODIBENZ(B,E)OXEPINILPENTANOICOS, SUS ANTIPODAS OPTICOS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R, R1 Y R2, H O ALQUILO DE C 1 A 5; X, ALQUILO O ALCOXI DE C 1 A 5, HAL Y OTROS; D.F., DE FORMULA; C.D.F, COMPUESTO D.F.; Y M, 0, 1 O 2. SE UTILIZAN COMO AGENTES CONTRA LA ARTRITIS.
ES542555A 1984-04-27 1985-04-25 Un procedimiento para preparar acidos (6,11-dihidro-11-oxo- dibenz(b,e,)oxepinil)pentanoicos Expired ES8608505A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60467284A 1984-04-27 1984-04-27

Publications (2)

Publication Number Publication Date
ES8608505A1 true ES8608505A1 (es) 1986-06-16
ES542555A0 ES542555A0 (es) 1986-06-16

Family

ID=24420536

Family Applications (2)

Application Number Title Priority Date Filing Date
ES542555A Expired ES8608505A1 (es) 1984-04-27 1985-04-25 Un procedimiento para preparar acidos (6,11-dihidro-11-oxo- dibenz(b,e,)oxepinil)pentanoicos
ES551427A Expired ES8704921A1 (es) 1984-04-27 1986-01-30 Un procedimiento para preparar acidos (6,11-dihidro-11-oxodibenz b,c, oxepinil) pentanoicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES551427A Expired ES8704921A1 (es) 1984-04-27 1986-01-30 Un procedimiento para preparar acidos (6,11-dihidro-11-oxodibenz b,c, oxepinil) pentanoicos

Country Status (8)

Country Link
EP (1) EP0159684B1 (es)
JP (1) JPS60243082A (es)
AT (1) ATE46692T1 (es)
DE (1) DE3573256D1 (es)
DK (1) DK189285A (es)
ES (2) ES8608505A1 (es)
GR (1) GR851016B (es)
PT (1) PT80359B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2181989B8 (en) * 2006-10-02 2013-09-25 Sumitomo Chemical Company, Ltd. Process for the preparation of olopatadine
JP5139016B2 (ja) * 2006-10-02 2013-02-06 住友化学株式会社 オキソジベンゾオキセピン酢酸第３級アルキルエステルの製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629569A1 (de) * 1975-07-30 1977-03-31 Hoechst Ag 6,11-dihydro-11-oxodibenz eckige klammer auf b,e eckige klammer zu oxepin-alkansaeuren und deren ester sowie verfahren zu ihrer herstellung
DE2716230A1 (de) * 1976-03-17 1977-10-27 Hoechst Ag Medikament zur behandlung von hautentzuendungen

Also Published As

Publication number Publication date
DE3573256D1 (en) 1989-11-02
JPS60243082A (ja) 1985-12-03
ES8704921A1 (es) 1987-04-16
PT80359B (en) 1987-02-11
PT80359A (en) 1985-05-01
ES542555A0 (es) 1986-06-16
EP0159684B1 (en) 1989-09-27
EP0159684A2 (en) 1985-10-30
GR851016B (es) 1985-11-25
EP0159684A3 (en) 1986-10-08
ES551427A0 (es) 1987-04-16
DK189285A (da) 1985-10-28
DK189285D0 (da) 1985-04-26
ATE46692T1 (de) 1989-10-15

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