ES8604584A1 - Procedimiento para la preparacion de un nuevo derivado de amida substituido - Google Patents

Procedimiento para la preparacion de un nuevo derivado de amida substituido

Info

Publication number
ES8604584A1
ES8604584A1 ES545336A ES545336A ES8604584A1 ES 8604584 A1 ES8604584 A1 ES 8604584A1 ES 545336 A ES545336 A ES 545336A ES 545336 A ES545336 A ES 545336A ES 8604584 A1 ES8604584 A1 ES 8604584A1
Authority
ES
Spain
Prior art keywords
het
pyridyl
naphthyridin
phenyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545336A
Other languages
English (en)
Other versions
ES545336A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of ES8604584A1 publication Critical patent/ES8604584A1/es
Publication of ES545336A0 publication Critical patent/ES545336A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN NUEVO DERIVADO DE AMIDA SUSTITUIDO. CONSISTE EN REACCIONAR A UNACIDO DE FORMULA (R-COOH) CON UNA AMINA DE FORMULA (HN2-HET) QUE TIENE UN RADICAL HIDROXI PROTEGIDO POR UN RADICAL TETRAHIDROPIRANILO, EN PRESENCIA DE UN AGENTE DE CONDENSACION PEPTIDICO COMO UNA CARBOIIMIDA, EN UN DISOLVENTE COMO UN ETER, DIOXANO, GLIMO O NITRILO, A UNA TEMPERATURA ENTRE 0JC Y 20JC Y ACIDOLESIS EN MEDIO ACUOSO, PARA ELIMINAR EL RADICAL TETRAHIDROPIRANILO Y OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R UN RADICAL CICLOALQUILO DE C 3 A 6, CICLOHEXADIENILO, FENILO, PIRIDILO-3-ALQUILOXIPIRIDILO-3, TIENILO Y OTROS Y HET UN RADICAL QUINOLILO-2 O NAFTIRIDINA-1,8-ILO-2 SUSTITUIDO EN POSICION-7 POR HAL Y POR HIDROXIMETILO Y OTROS. SE UTILIZA COMO ANXIOLITICA, HIPNOTICA, ANTICONVULSIONANTES.
ES545336A 1984-07-19 1985-07-18 Procedimiento para la preparacion de un nuevo derivado de amida substituido Expired ES8604584A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8411442A FR2567887B1 (fr) 1984-07-19 1984-07-19 Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent

Publications (2)

Publication Number Publication Date
ES8604584A1 true ES8604584A1 (es) 1986-02-01
ES545336A0 ES545336A0 (es) 1986-02-01

Family

ID=9306273

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545336A Expired ES8604584A1 (es) 1984-07-19 1985-07-18 Procedimiento para la preparacion de un nuevo derivado de amida substituido

Country Status (27)

Country Link
US (1) US4642308A (es)
EP (1) EP0172083B1 (es)
JP (1) JPS6163656A (es)
KR (1) KR860001100A (es)
AT (1) ATE33652T1 (es)
AU (1) AU572672B2 (es)
CA (1) CA1224787A (es)
CS (1) CS253730B2 (es)
DD (1) DD240011A5 (es)
DE (1) DE3562250D1 (es)
DK (1) DK327285A (es)
ES (1) ES8604584A1 (es)
FI (1) FI79313C (es)
FR (1) FR2567887B1 (es)
GR (1) GR851774B (es)
HU (1) HU199802B (es)
IL (1) IL75817A (es)
MA (1) MA20487A1 (es)
NO (1) NO161673C (es)
NZ (1) NZ212764A (es)
OA (1) OA08069A (es)
PH (1) PH21301A (es)
PL (1) PL145331B1 (es)
PT (1) PT80840B (es)
SU (1) SU1417797A3 (es)
YU (1) YU118785A (es)
ZA (1) ZA855409B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4720500A (en) * 1985-07-11 1988-01-19 Rhone-Poulenc Sante N-1,8-naphthyridin-2-yl amides useful as immunostimulants
FR2592882B2 (fr) * 1986-01-16 1988-03-11 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
US4753941A (en) * 1986-01-16 1988-06-28 Rhone-Poulenc Sante Amides based on certain 1,8-naphtyridine-2-amines useful as anxiolytics
US5197518A (en) * 1991-06-27 1993-03-30 Double Containment Systems Centering support assembly for double containment pipe systems
GB9711257D0 (en) * 1997-05-30 1997-07-30 Smithkline Beecham Plc Novel compounds
JP2002537396A (ja) * 1999-02-22 2002-11-05 バイオケム ファーマ インコーポレイテッド 抗ウィルス活性を有する［１，８］ナフチリジン誘導体
WO2005046683A1 (en) * 2003-10-07 2005-05-26 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US20080300243A1 (en) * 2005-02-28 2008-12-04 Kelly Michael G Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2013090725A1 (en) * 2011-12-15 2013-06-20 Philadelphia Health & Education Corporation NOVEL PI3K p110 INHIBITORS AND METHODS OF USE THEREOF
CN105646487B (zh) * 2016-03-15 2017-12-05 红河学院 一类溴代1,8‑萘啶衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB661515A (en) * 1948-08-31 1951-11-21 Cilag Ltd Process for the production of naphthyridine derivatives
FR1006725A (fr) * 1948-08-31 1952-04-28 Cilag Spa Nouveaux dérivés de la naphtyridine et procédé pour leur préparation
US3389142A (en) * 1966-09-29 1968-06-18 Bristol Myers Co Esters of 2-substituted 1, 2-dihydroquinoline-nu-carboxylic acids and thione acids
US3576809A (en) * 1968-05-06 1971-04-27 Miles Lab 2-substituted derivatives of 6-methoxyquinoline
US3624097A (en) * 1969-07-22 1971-11-30 Warner Lambert Co N-pyridine 5-aminooxazoles
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use

Also Published As

Publication number Publication date
NZ212764A (en) 1988-05-30
CS253730B2 (en) 1987-12-17
MA20487A1 (fr) 1986-04-01
AU4509085A (en) 1986-01-23
EP0172083B1 (fr) 1988-04-20
PH21301A (en) 1987-09-28
IL75817A (en) 1988-06-30
PL254570A1 (en) 1986-10-21
PL145331B1 (en) 1988-09-30
ZA855409B (en) 1986-04-30
FI852821L (fi) 1986-01-20
DK327285A (da) 1986-01-20
NO161673C (no) 1989-09-13
NO161673B (no) 1989-06-05
ES545336A0 (es) 1986-02-01
PT80840A (fr) 1985-08-01
DD240011A5 (de) 1986-10-15
NO852877L (no) 1986-01-20
DK327285D0 (da) 1985-07-18
US4642308A (en) 1987-02-10
PT80840B (pt) 1988-02-17
CA1224787A (fr) 1987-07-28
IL75817A0 (en) 1985-11-29
SU1417797A3 (ru) 1988-08-15
FI852821A0 (fi) 1985-07-18
HU199802B (en) 1990-03-28
GR851774B (es) 1985-11-26
YU118785A (en) 1988-10-31
FR2567887B1 (fr) 1986-12-19
ATE33652T1 (de) 1988-05-15
KR860001100A (ko) 1986-02-22
OA08069A (fr) 1987-03-31
JPS6163656A (ja) 1986-04-01
HUT40799A (en) 1987-02-27
AU572672B2 (en) 1988-05-12
FI79313B (fi) 1989-08-31
FI79313C (fi) 1989-12-11
FR2567887A1 (fr) 1986-01-24
EP0172083A1 (fr) 1986-02-19
DE3562250D1 (en) 1988-05-26

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401