ES8603405A1 - "procedimiento para la obtencion del ester benzilico de 1-(n-(1--etoxicarbonil-3-oxo-fenilpropil)-l-alanil)-l-prolina". - Google Patents
"procedimiento para la obtencion del ester benzilico de 1-(n-(1--etoxicarbonil-3-oxo-fenilpropil)-l-alanil)-l-prolina".Info
- Publication number
- ES8603405A1 ES8603405A1 ES542440A ES542440A ES8603405A1 ES 8603405 A1 ES8603405 A1 ES 8603405A1 ES 542440 A ES542440 A ES 542440A ES 542440 A ES542440 A ES 542440A ES 8603405 A1 ES8603405 A1 ES 8603405A1
- Authority
- ES
- Spain
- Prior art keywords
- benzyl ester
- proline
- proline benzyl
- ester deriv
- deriv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VVCLBQFBKZQOAF-NSHDSACASA-N benzyl (2s)-pyrrolidine-2-carboxylate Chemical compound O=C([C@H]1NCCC1)OCC1=CC=CC=C1 VVCLBQFBKZQOAF-NSHDSACASA-N 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- -1 benzyl ester Chemical class 0.000 abstract 2
- MXCSVTIFEAAXAA-VFDRBLODSA-N (2s)-1-[(2s)-2-[(1-ethoxy-1,4-dioxo-4-phenylbutan-2-yl)amino]propanoyl]pyrrolidine-2-carboxylic acid Chemical compound N([C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(C(=O)OCC)CC(=O)C1=CC=CC=C1 MXCSVTIFEAAXAA-VFDRBLODSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- 229930182821 L-proline Natural products 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES542440A ES8603405A1 (es) | 1985-04-22 | 1985-04-22 | "procedimiento para la obtencion del ester benzilico de 1-(n-(1--etoxicarbonil-3-oxo-fenilpropil)-l-alanil)-l-prolina". |
| YU402/86A YU44546B (en) | 1985-04-22 | 1986-03-17 | Process for obtaining benzyl esther 1-/n-(1-etoxi carbonyl-3-oxo-3-phenyl-propyl)-l-alanyl/-l-proline |
| CS862860A CS266584B2 (en) | 1985-04-22 | 1986-04-18 | Method of 1-/n-(1-ethoxy carbonyl-3-oxo-3-phenylpropyl)-l-alanyl/-l-proline's benzyl esther production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES542440A ES8603405A1 (es) | 1985-04-22 | 1985-04-22 | "procedimiento para la obtencion del ester benzilico de 1-(n-(1--etoxicarbonil-3-oxo-fenilpropil)-l-alanil)-l-prolina". |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES542440A0 ES542440A0 (es) | 1985-12-16 |
| ES8603405A1 true ES8603405A1 (es) | 1985-12-16 |
Family
ID=8489045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542440A Expired ES8603405A1 (es) | 1985-04-22 | 1985-04-22 | "procedimiento para la obtencion del ester benzilico de 1-(n-(1--etoxicarbonil-3-oxo-fenilpropil)-l-alanil)-l-prolina". |
Country Status (3)
| Country | Link |
|---|---|
| CS (1) | CS266584B2 (cs) |
| ES (1) | ES8603405A1 (cs) |
| YU (1) | YU44546B (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2377868A1 (en) * | 2004-03-30 | 2011-10-19 | Millennium Pharmaceuticals, Inc. | Synthesis of Bortezomib |
-
1985
- 1985-04-22 ES ES542440A patent/ES8603405A1/es not_active Expired
-
1986
- 1986-03-17 YU YU402/86A patent/YU44546B/xx unknown
- 1986-04-18 CS CS862860A patent/CS266584B2/cs unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2377868A1 (en) * | 2004-03-30 | 2011-10-19 | Millennium Pharmaceuticals, Inc. | Synthesis of Bortezomib |
Also Published As
| Publication number | Publication date |
|---|---|
| CS286086A2 (en) | 1989-04-14 |
| CS266584B2 (en) | 1990-01-12 |
| ES542440A0 (es) | 1985-12-16 |
| YU44546B (en) | 1990-08-31 |
| YU40286A (en) | 1987-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050924 |