ES8603272A1 - Procedimiento de producir un preparado de farmaco de toxicidad reducida - Google Patents
Procedimiento de producir un preparado de farmaco de toxicidad reducidaInfo
- Publication number
- ES8603272A1 ES8603272A1 ES532818A ES532818A ES8603272A1 ES 8603272 A1 ES8603272 A1 ES 8603272A1 ES 532818 A ES532818 A ES 532818A ES 532818 A ES532818 A ES 532818A ES 8603272 A1 ES8603272 A1 ES 8603272A1
- Authority
- ES
- Spain
- Prior art keywords
- drug
- reduced toxicity
- drug preparations
- preparations
- toxicity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 5
- 229940079593 drug Drugs 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 3
- 231100000419 toxicity Toxicity 0.000 title abstract 2
- 230000001988 toxicity Effects 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49826883A | 1983-05-26 | 1983-05-26 | |
| US60450384A | 1984-05-02 | 1984-05-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532818A0 ES532818A0 (es) | 1985-12-16 |
| ES8603272A1 true ES8603272A1 (es) | 1985-12-16 |
Family
ID=27052776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532818A Expired ES8603272A1 (es) | 1983-05-26 | 1984-05-25 | Procedimiento de producir un preparado de farmaco de toxicidad reducida |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4897384A (OSRAM) |
| KR (1) | KR850002401A (OSRAM) |
| CA (1) | CA1237670A (OSRAM) |
| ES (1) | ES8603272A1 (OSRAM) |
| GR (1) | GR79953B (OSRAM) |
| IL (1) | IL71908A0 (OSRAM) |
| IT (1) | IT1178947B (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409704A (en) * | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| US4871718A (en) * | 1987-12-29 | 1989-10-03 | Raymond A. Roncari | Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair |
| US20010051183A1 (en) * | 1989-10-20 | 2001-12-13 | Alza Corporation | Liposomes with enhanced circulation time and method of treatment |
| JPH07501521A (ja) * | 1991-10-21 | 1995-02-16 | スフィンクス・ファーマスーティカルズ・コーポレーション | ２−アミノプロパン１，３−ジオール化学療法剤 |
| US5958449A (en) | 1992-12-02 | 1999-09-28 | Nexstar Pharmaceuticals, Inc. | Antibiotic formulation and use for bacterial infections |
| AU3244393A (en) * | 1992-12-02 | 1994-06-22 | Vestar, Inc. | Antibiotic formulation and process |
| CA2159596C (en) * | 1993-04-02 | 2002-06-11 | Royden Coe | Method of producing liposomes |
| US5759571A (en) * | 1993-05-11 | 1998-06-02 | Nexstar Pharmaceuticals, Inc. | Antibiotic formulation and use for drug resistant infections |
| CA2166465C (en) | 1993-07-08 | 2003-10-14 | Laura M. Edgerly-Pflug | Method of controlling the size of liposomes |
| US5716526A (en) * | 1994-01-14 | 1998-02-10 | The Liposome Company, Inc. | Method of separating materials from liposomes or lipid complexes |
| US6045774A (en) * | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
| CA2276046A1 (en) * | 1997-01-10 | 1998-07-16 | Epicyte Pharmaceutical, Inc. | Novel epithelial tissue targeting agent |
| US6165997A (en) * | 1997-11-20 | 2000-12-26 | Statens Serum Institut | Phospholipids having antimicrobial activity with or without the presence of antimicrobials |
| US6258375B1 (en) * | 1998-03-05 | 2001-07-10 | Abbott Laboratories | Antibacterial phosphoinositides |
| US6194379B1 (en) | 1998-05-01 | 2001-02-27 | Abbott Laboratories | Elemental enteral formula |
| EP1119315A4 (en) * | 1998-09-30 | 2002-04-17 | Univ Utah Res Found | DELIVERY OF PHOSPHOINOSTIDIDPOLYPHOSPHATES INTO THE CELL |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| WO2003075890A1 (en) * | 2002-03-05 | 2003-09-18 | Transave, Inc. | Methods for entrapment of bioactive agent in a liposome or lipid complex |
| US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| US7544369B2 (en) * | 2002-10-29 | 2009-06-09 | Transave, Inc. | Sustained release of antiinfectives |
| AU2006322076C1 (en) | 2005-12-08 | 2013-11-14 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| US20100196455A1 (en) | 2007-05-04 | 2010-08-05 | Transave, Inc. | Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof |
| US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
| US20090061009A1 (en) * | 2007-08-29 | 2009-03-05 | Joseph Schwarz | Composition and Method of Treatment of Bacterial Infections |
| ES2969659T3 (es) | 2012-05-21 | 2024-05-21 | Insmed Inc | Sistemas para el tratamiento de infecciones pulmonares |
| EP3581186A1 (en) | 2012-11-29 | 2019-12-18 | Insmed Incorporated | Stabilized vancomycin formulations |
| ES2820226T3 (es) | 2014-05-15 | 2021-04-20 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
| US11571386B2 (en) | 2018-03-30 | 2023-02-07 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| EP4312536A1 (en) | 2021-04-01 | 2024-02-07 | Vestaron Corporation | Liposome formulations for pesticide delivery and methods for producing and using the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3962429A (en) * | 1973-08-01 | 1976-06-08 | Chugai Seiyaku Kabushiki Kaisha | Method for reducing side effects of aminoglycoside antibiotics and composition therefor |
| TR19072A (tr) * | 1973-11-26 | 1978-05-01 | Pepro | Fosforlu tuerevler ihtiva eden fungisid terkipler |
| US4119724A (en) * | 1973-11-26 | 1978-10-10 | Pepro | Fungicidal compositions containing phosphorous acid and derivatives thereof |
| US3993754A (en) * | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
| US4160827A (en) * | 1978-02-06 | 1979-07-10 | The Upjohn Company | Metronidazole phosphate and salts |
| US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IL55431A (en) * | 1978-08-24 | 1982-07-30 | Yeda Res & Dev | Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them |
| DE2856333C2 (de) * | 1978-12-27 | 1983-09-22 | A. Nattermann & Cie GmbH, 5000 Köln | Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung |
| US4272525A (en) * | 1978-10-23 | 1981-06-09 | Schering Corporation | Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them |
| GR73668B (OSRAM) * | 1978-11-21 | 1984-03-28 | Hoffmann La Roche | |
| GB2046092B (en) * | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
| US4291023A (en) * | 1979-03-07 | 1981-09-22 | Engelhard Minerals & Chemicals Corp. | Method for treating tumors using cis-diammineplatinum (II) organophosphate complexes |
| US4291027A (en) * | 1979-03-07 | 1981-09-22 | Engelhard Minerals & Chemicals Corp. | Method for treating tumors with ethylenediamine platinum (II) and 1,2-diaminocyclohexane-platinum (II) pyrophosphate complexes |
| US4287187A (en) * | 1979-03-07 | 1981-09-01 | Engelhard Minerals & Chemicals Corporation | Method for treating tumors with cis-diammineplatinum(II) orthophosphate complexes |
| JPS55127162A (en) * | 1979-03-22 | 1980-10-01 | Fujio Kurata | System and apparatus for protecting insulator in electric dust collector |
| DE2914789A1 (de) * | 1979-04-11 | 1980-10-16 | Nattermann A & Cie | Injizierbare arzneimittel mit entzuendungshemmender wirkung |
| CA1173360A (en) * | 1979-06-22 | 1984-08-28 | Jurg Schrank | Pharmaceutical preparations |
| DE2952115C2 (de) * | 1979-12-22 | 1982-05-06 | A. Nattermann & Cie GmbH, 5000 Köln | Rosmarinsäure-Phospholipid-Komplex |
| US4346084A (en) * | 1980-02-29 | 1982-08-24 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering lithium and choline |
| US4430330A (en) * | 1980-02-29 | 1984-02-07 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering a phenothiazine and choline |
| US4419348A (en) * | 1981-04-27 | 1983-12-06 | Georgetown University | Anthracycline glycoside compositions, their use and preparation |
| US4397846A (en) * | 1981-05-15 | 1983-08-09 | Murray Weiner | Storage-stable lipid vesicles and method of preparation |
| DE3125422A1 (de) * | 1981-06-27 | 1983-01-27 | A. Nattermann & Cie GmbH, 5000 Köln | Neue fungizid-zusammensetzung, verfahren zur herstellung und deren verwendung |
| DE3125423A1 (de) * | 1981-06-27 | 1983-01-13 | A. Nattermann & Cie GmbH, 5000 Köln | Neue insektizid-zusammensetzung, verfahren zur herstellung und deren verwendung |
-
1984
- 1984-05-11 CA CA000454193A patent/CA1237670A/en not_active Expired
- 1984-05-16 GR GR74739A patent/GR79953B/el unknown
- 1984-05-23 IL IL71908A patent/IL71908A0/xx unknown
- 1984-05-25 IT IT67535/84A patent/IT1178947B/it active
- 1984-05-25 ES ES532818A patent/ES8603272A1/es not_active Expired
- 1984-05-26 KR KR1019840002901A patent/KR850002401A/ko not_active Ceased
-
1986
- 1986-03-24 US US06/844,248 patent/US4897384A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1237670A (en) | 1988-06-07 |
| IT1178947B (it) | 1987-09-16 |
| IT8467535A1 (it) | 1985-11-25 |
| GR79953B (OSRAM) | 1984-10-31 |
| KR850002401A (ko) | 1985-05-13 |
| IT8467535A0 (it) | 1984-05-25 |
| IL71908A0 (en) | 1984-09-30 |
| US4897384A (en) | 1990-01-30 |
| ES532818A0 (es) | 1985-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8603272A1 (es) | Procedimiento de producir un preparado de farmaco de toxicidad reducida | |
| NL190664C (nl) | Gesubstitueerde benzhydrylpiperidinoderivaten met therapeutische werking en farmaceutische preparaten die deze verbindingen bevatten. | |
| ATE37028T1 (de) | Cephalosporinverbindungen, ihre herstellung, pharmazeutische praeparate und eingangsprodukte. | |
| DE3580616D1 (de) | Mitomycinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen. | |
| AU4690379A (en) | Administering intravenous drugs | |
| ES8308211A1 (es) | Un metodo de preparar un polvo seco que comprende un farmaco encapsulado con etilcelulosa, poli (acetato de vinilo) u otros polimeros. | |
| NL190580C (nl) | Gesubstitueerde benzhydrylpiperidinederivaten met therapeutische werking en preparaten die deze stoffen bevatten. | |
| NO875299D0 (no) | Insulinpreparat for ikke-paranteral administrasjon. | |
| ATE5508T1 (de) | Praeparate zur parenteralen verabreichung fettloeslicher wirkstoffe. | |
| SG18792G (en) | Drug preparations of reduced toxicity | |
| NL194239B (nl) | Dialkoxyfosfinolmethylbenzamideverbindingen en farmaceutische preparaten, die deze bevatten. | |
| FI872652A7 (fi) | Hidasluovutteiset farmaseuttiset valmisteet. | |
| DE3669104D1 (de) | Pharmazeutische praeparate, die ascorbinsaeurederivate enthalten. | |
| MX18786A (es) | Complejos macrociclicos de acido aminofonico, su preparacion, formulaciones y empleo. | |
| DE3789431D1 (de) | Jod enthaltende Verbindung und ihre Herstellung. | |
| NO893062D0 (no) | Anvendelse av isokinolinforbindelser, saerlig i inhalasjonspreparater. | |
| DE3164719D1 (en) | Drugs with cytostatic activity, derivatives of isocyanuric acid and process for their preparation | |
| DE3867086D1 (de) | Benzothiepino(5,4-c)pyridazin-verbindungen und ihre pharmazeutischen wirkungen. | |
| ATA574379A (de) | Neue n-phenylindolinderivate, ihre herstellung undpharmazeutische praeparate, welche diese verbindungen enthalten | |
| ATE32882T1 (de) | Phenylnonatetraensaeurederivate, ihre herstellung und pharmazeutische praeparate mit diesen derivaten. | |
| DE3586952D1 (de) | Fibrinophiler urokinase-komplex und dessen herstellung. | |
| ZA854905B (en) | Cis-platinum(ii)complexes with diamino-sugar derivatives as ligands,processes for their preparation and medicaments containing these complexes | |
| IT8722218A0 (it) | Ftalazino derivati ad attivita'farmaceutica. | |
| FI74003B (fi) | Foerfarande foer framstaellning av en terapeutiskt anvaendbar 5,14-dihydrobens/5,6/isoindolo/2,1-b/isokinolin- 8,13-dion. | |
| IL77009A0 (en) | Biphenylyloxy and biphenylylalkoxy aryl acyl urea derivatives,processes for the preparation thereof and pesticidal compositions containing the same |