ES8602849A1 - Procedimiento para preparar un analogo polipeptido - Google Patents

Procedimiento para preparar un analogo polipeptido

Info

Publication number
ES8602849A1
ES8602849A1 ES530262A ES530262A ES8602849A1 ES 8602849 A1 ES8602849 A1 ES 8602849A1 ES 530262 A ES530262 A ES 530262A ES 530262 A ES530262 A ES 530262A ES 8602849 A1 ES8602849 A1 ES 8602849A1
Authority
ES
Spain
Prior art keywords
arg
pro
opt
residue
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530262A
Other languages
English (en)
Other versions
ES530262A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring AB
Original Assignee
Ferring AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring AB filed Critical Ferring AB
Publication of ES530262A0 publication Critical patent/ES530262A0/es
Publication of ES8602849A1 publication Critical patent/ES8602849A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN ANALOGO POLIPEPTIDO. CONSISTE EN HACER REACCIONAR EN DIMETILFORMAIDA O DICLOROMETANO, UN ANALOGO DIPEPTIDO HIDROXI, <REDUCIDO> CON UN PRIMER RESIDUO (TERMINAL AMINO) COMO ARGINA Y EL SEGUNDO RESIDUO (TERMINAL CARBOXILO) COMO RESIDUO GLICINA O ALANINA, CON COMPUESTOS QUE AÑADEN, EN EL TERMINAL CARBOXILO, SUCESIVAMENTE UN RESIDUO PRO, UN RESIDUO ARG, UN RESIDUO VALINA O PROLINA O UN GRUPO QUE FORMA (CON W) UN AMINOALCOHOL Y, EN EL TERMINAL AMINO, SUCESIVAMENTE, UN RESIDUO DE GLICINA O N-METILALANINA, UN RESIDUO DE GLICINA O FENILALANINA, PARA OBTENER UN ANALOGO POLIPEPTIDO DE FORMULA (I). SIENDO: X H O UN GRUPO PROTECTOR INCLUYENDO ALQUILO INFERIOR (C1-C5), O ACILO ALIFATICO INFERIOR (C1-C5) Y OTROS; Y GLICINA, O D- O L-FENILALANINA Y OTROS; Y Z L- O D-PROLINA O L- O D-VALINA Y OTROS. SE UTILIZAN COMO AGENTES ANTITROMBOTICOS Y ANTICOAGULANTES.
ES530262A 1983-03-04 1984-03-02 Procedimiento para preparar un analogo polipeptido Expired ES8602849A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838305985A GB8305985D0 (en) 1983-03-04 1983-03-04 Enzyme inhibition

Publications (2)

Publication Number Publication Date
ES530262A0 ES530262A0 (es) 1985-12-01
ES8602849A1 true ES8602849A1 (es) 1985-12-01

Family

ID=10538985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530262A Expired ES8602849A1 (es) 1983-03-04 1984-03-02 Procedimiento para preparar un analogo polipeptido

Country Status (13)

Country Link
US (2) US4638047A (es)
EP (1) EP0118280B1 (es)
JP (1) JPS60500870A (es)
AT (1) ATE44533T1 (es)
AU (1) AU596783B2 (es)
CA (1) CA1322078C (es)
DE (1) DE3478928D1 (es)
DK (1) DK520284A (es)
ES (1) ES8602849A1 (es)
FI (1) FI88398C (es)
GB (1) GB8305985D0 (es)
IE (1) IE56958B1 (es)
WO (1) WO1984003507A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
US4812442A (en) * 1984-05-29 1989-03-14 Merck & Co., Inc. Tripeptide renin inhibitors
DE3438545A1 (de) * 1984-10-20 1986-04-24 Merck Patent Gmbh, 6100 Darmstadt Peptide
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4705778A (en) * 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US4859654A (en) * 1987-07-01 1989-08-22 Pfizer Inc. Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
US5028590A (en) * 1988-04-11 1991-07-02 Eli Lilly And Company Derivatives of A54145 cyclic peptides
US5039789A (en) * 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US4994270A (en) * 1988-04-11 1991-02-19 Eli Lilly And Company A54145 antibiotics and process for their production
US5574014A (en) * 1988-04-28 1996-11-12 Thrombosis Research Institute Inhibitors of trypsin-like enzymes
US6313096B1 (en) 1988-04-28 2001-11-06 Trigen Limited Inhibitors of trypsin-like enzymes
US6218364B1 (en) 1988-06-20 2001-04-17 Scott L. Harbeson Fluorinated neurokinin A antagonists
US5830863A (en) * 1988-06-20 1998-11-03 Merrell Pharmaceuticals Inc. Neurokinin A antagonists
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
WO1990013562A1 (en) * 1989-05-02 1990-11-15 Genelabs Incorporated Chemically modified cd4 peptide fragments having anti-retroviral properties
US5187155A (en) * 1989-06-23 1993-02-16 Board Of Regents, The University Of Texas System Anticoagulant peptides
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5338723A (en) * 1989-10-13 1994-08-16 Merck & Co., Inc. Fibrinogen receptor antagonists
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
US5190919A (en) * 1989-11-13 1993-03-02 Board Of Regents, The University Of Texas System Antihemostatic factor vii peptides
AU654820B2 (en) * 1990-06-15 1994-11-24 Majesty (Her) In Right Of Canada As Represented By The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
ATE174603T1 (de) * 1991-02-04 1999-01-15 Akzo Nobel Nv Faktor iia inhibitoren
WO1993003748A1 (en) * 1991-08-13 1993-03-04 Temple University - Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
JP4010560B2 (ja) * 1992-07-20 2007-11-21 ドューク ユニバーシティー Ｈｉｖ複製を阻害する化合物
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
GB9502985D0 (en) * 1995-02-16 1995-04-05 Thrombosis Res Inst Enzyme inhibitors
MX9706069A (es) * 1995-02-17 1997-10-31 Basf Ag Nuevos inhibidores de la trombina.
AU703256B2 (en) * 1995-06-09 1999-03-25 Regents Of The University Of Michigan, The Bradykinin analogs as selective thrombin inhibitors
US6982249B1 (en) 1997-04-23 2006-01-03 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
JP2002501081A (ja) 1998-01-26 2002-01-15 ビーエーエスエフ アクチェンゲゼルシャフト トロンビンインヒビター
DE10254993A1 (de) * 2002-11-26 2004-06-09 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Säureamidarginine und deren Ester sowie deren Verwendung zur Konservierung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2058077B (en) * 1979-06-08 1983-03-09 Szelke M Enkephalin analogues
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors

Also Published As

Publication number Publication date
FI844230A0 (fi) 1984-10-29
AU596783B2 (en) 1990-05-17
DK520284D0 (da) 1984-11-01
ES530262A0 (es) 1985-12-01
DK520284A (da) 1984-11-01
IE56958B1 (en) 1992-02-12
CA1322078C (en) 1993-09-07
EP0118280B1 (en) 1989-07-12
US4638047A (en) 1987-01-20
FI88398B (fi) 1993-01-29
ATE44533T1 (de) 1989-07-15
AU2651684A (en) 1984-09-28
DE3478928D1 (en) 1989-08-17
FI844230L (fi) 1984-10-29
US4772686A (en) 1988-09-20
WO1984003507A1 (en) 1984-09-13
EP0118280A1 (en) 1984-09-12
IE840474L (en) 1984-09-04
FI88398C (fi) 1993-05-10
JPS60500870A (ja) 1985-06-06
GB8305985D0 (en) 1983-04-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102