ES8602762A1 - Metodo de obtener compuestos utiles como agentes inhibidores de la agregacion de plaquetas - Google Patents

Metodo de obtener compuestos utiles como agentes inhibidores de la agregacion de plaquetas

Info

Publication number
ES8602762A1
ES8602762A1 ES535122A ES535122A ES8602762A1 ES 8602762 A1 ES8602762 A1 ES 8602762A1 ES 535122 A ES535122 A ES 535122A ES 535122 A ES535122 A ES 535122A ES 8602762 A1 ES8602762 A1 ES 8602762A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
compositions containing
piperidine
preparation
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535122A
Other languages
English (en)
Other versions
ES535122A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp filed Critical Research Corp
Publication of ES535122A0 publication Critical patent/ES535122A0/es
Publication of ES8602762A1 publication Critical patent/ES8602762A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DIAMIDICOS UTILES COMO AGENTES INHIBIDORES DE LA AGREGACION DE PLAQUETAS, EN PARTICULAR PARA LA PREPARACION DE COMPUESTOS DE FORMULA GENERAL (I), EN LA QUE Y1 E Y2 SON RADICALES; Y Z ES UN RADICAL DIAMINICA ORGANICO DE FORMULA: R2N-X-NR3, EN LA QUE X ES UN RADICAL HIDROCARBILO; Y R2 Y R3 SON CADA UNO DE ELLOS H O ALQUILO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, INCLUYENDO LAS SALES CUATERNARIAS. CONSISTE EN ACILAR UNA DIAMINA ADECUADA CON UN DERIVADO DEL ACIDO ELEGIDO, TAL COMO UN HALURO DE ACIDO, PARA OBTENER LA DIAMIDA Y EN SU CASO SE FORMAN SUS SALES CON ACIDOS O SALES CUATERNARIAS, FARMACEUTICAMENTE ACEPTABLES, POR REACCION CON HALUROS DE ALQUILO. DE APLICACION EN EL TRATAMIENTO Y PREVENCION DE LAS ENFERMEDADES TROMBOEMBOLICAS.
ES535122A 1982-04-15 1984-08-14 Metodo de obtener compuestos utiles como agentes inhibidores de la agregacion de plaquetas Expired ES8602762A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/368,863 US4443450A (en) 1982-04-15 1982-04-15 Platelet aggregation inhibitory agents and intermediates therefor

Publications (2)

Publication Number Publication Date
ES535122A0 ES535122A0 (es) 1985-12-16
ES8602762A1 true ES8602762A1 (es) 1985-12-16

Family

ID=23453081

Family Applications (2)

Application Number Title Priority Date Filing Date
ES521794A Granted ES521794A0 (es) 1982-04-15 1983-04-15 Procedimiento de obtencion de compuestos para la preparacion de agentes inhibidores de la agregacion de plaquetas.
ES535122A Expired ES8602762A1 (es) 1982-04-15 1984-08-14 Metodo de obtener compuestos utiles como agentes inhibidores de la agregacion de plaquetas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES521794A Granted ES521794A0 (es) 1982-04-15 1983-04-15 Procedimiento de obtencion de compuestos para la preparacion de agentes inhibidores de la agregacion de plaquetas.

Country Status (12)

Country Link
US (1) US4443450A (es)
EP (1) EP0096735B1 (es)
JP (1) JPS58192869A (es)
AU (1) AU556925B2 (es)
CA (1) CA1256438A (es)
DE (1) DE3380875D1 (es)
DK (1) DK163919C (es)
ES (2) ES521794A0 (es)
GR (1) GR78182B (es)
IE (1) IE55561B1 (es)
IL (1) IL68423A (es)
ZA (1) ZA832584B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994462A (en) * 1982-04-15 1991-02-19 Research Corporation Platelet aggregation inhibitory agents and intermediate therefor
US4798830A (en) * 1982-04-15 1989-01-17 Research Corporation Platelet aggregation inhibitory agents and intermediates therefor
AT392783B (de) * 1987-10-08 1991-06-10 Warner Lambert Co Neue n-substituierte 3-piperidin- oder 3-tetrahydropyridincarbonsaeuren und derivate
JPH0623031U (ja) * 1992-08-25 1994-03-25 青山眼鏡株式会社 眼鏡セット
JP2000500467A (ja) * 1995-11-13 2000-01-18 スミスクライン・ビーチャム・コーポレイション 血液調節化合物
CN109824704B (zh) * 2019-03-15 2021-01-15 郑州轻工业学院 一种基于Evans-Showell型多酸的金属-有机配合物及其制备方法、应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2798070A (en) * 1954-02-04 1957-07-02 Mcneilab Inc Quaternary quinoline carboxamide salts and method of preparing same
NL289475A (es) * 1962-03-01
SE431092B (sv) * 1979-07-10 1984-01-16 Thuresson Af Ekenstam Bo Terapeutiskt aktiva, substituerade piperidinkarboxianilider

Also Published As

Publication number Publication date
ZA832584B (en) 1983-12-28
US4443450A (en) 1984-04-17
IE830825L (en) 1983-10-15
IL68423A (en) 1986-08-31
DK163919C (da) 1992-09-21
ES535122A0 (es) 1985-12-16
DK167083D0 (da) 1983-04-15
JPH0530828B2 (es) 1993-05-11
EP0096735A3 (en) 1986-08-20
EP0096735A2 (en) 1983-12-28
GR78182B (es) 1984-09-26
IE55561B1 (en) 1990-11-07
ES8503347A1 (es) 1985-03-01
DE3380875D1 (en) 1989-12-28
CA1256438A (en) 1989-06-27
AU1341183A (en) 1983-10-20
AU556925B2 (en) 1986-11-27
ES521794A0 (es) 1985-03-01
JPS58192869A (ja) 1983-11-10
DK167083A (da) 1983-10-16
EP0096735B1 (en) 1989-11-23
DK163919B (da) 1992-04-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303