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Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Original Assignee
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
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Publication date
Application filed by Sociedad Espanola de Especialidades Farmaco Terapeuticas SAfiledCriticalSociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority to ES540496ApriorityCriticalpatent/ES540496A0/en
Publication of ES8602601A1publicationCriticalpatent/ES8602601A1/en
Publication of ES540496A0publicationCriticalpatent/ES540496A0/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Trans-4-(2-amino 3,5 -dibromobenzylamino)cyclohexanol of formula (I) is made by (a) reacting a cpd. of formula (II) with bromine to give 2-acetamido 5-bromobenzaldehyde (III) (b) reacting this with a cpd. (IV) in presence of a reducing agent, e.g. sodium borohydride to give trans-4-(2-acetamido 5-bromo benzylamino) cyclohexanol (V) (c) hydrolysing to trans-4-(2-amino 5-bromobenzyl-amino) cyclohexanol (VI) and (d) reacting with bromine in equimolar amount to obtain
ES540496A1985-02-181985-02-18
PROCEDURE FOR OBTAINING A HALOGENATED DERIVATIVE OF ANILINE
GrantedES540496A0
(en)