IT1058284B - Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid - Google Patents
Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acidInfo
- Publication number
- IT1058284B IT1058284B IT2116574A IT2116574A IT1058284B IT 1058284 B IT1058284 B IT 1058284B IT 2116574 A IT2116574 A IT 2116574A IT 2116574 A IT2116574 A IT 2116574A IT 1058284 B IT1058284 B IT 1058284B
- Authority
- IT
- Italy
- Prior art keywords
- diamino
- methylamino
- glutamic acid
- pteridyl
- methyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prepn. of N p-( 2,4-4-diamino-6-pteridyl)-methyl -N10-methylamino)-benzoyl - -glutamic acid, (Ie, having formula involves (1) prepn. of 2,4-diamino-6-hydroxymethyl-pteridine (II) by reacting a salt (A) of 2.4,5,6-tetraamino-pyrimidine with the bisulphite (B) of 1,3-dihydroxyacetone in aq. medium, with addn. of air, using thioalcohols as catalysts and oxidn. agents, pref. SeO2; (2) halogenating (II) to 2,4-diamino-6-halomethyl-pteridine (III), with ahalogenating agent, pref, thionyl chloride or P oxychloride, in an inert medium, in presence of a basic catalyst, pref. pyridine or Net3, and (3) condensing (III) with N p-(N-methylamino)-benzoyl -glutamic acid (C) in a buffered aq. medium. Higher yields, e.g. 10-15% and purity >95% are obtd.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2116574A IT1058284B (en) | 1974-04-08 | 1974-04-08 | Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2116574A IT1058284B (en) | 1974-04-08 | 1974-04-08 | Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
IT1058284B true IT1058284B (en) | 1982-04-10 |
Family
ID=11177719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2116574A IT1058284B (en) | 1974-04-08 | 1974-04-08 | Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1058284B (en) |
-
1974
- 1974-04-08 IT IT2116574A patent/IT1058284B/en active
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