IT1058284B - Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid - Google Patents

Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

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Publication number
IT1058284B
IT1058284B IT2116574A IT2116574A IT1058284B IT 1058284 B IT1058284 B IT 1058284B IT 2116574 A IT2116574 A IT 2116574A IT 2116574 A IT2116574 A IT 2116574A IT 1058284 B IT1058284 B IT 1058284B
Authority
IT
Italy
Prior art keywords
diamino
methylamino
glutamic acid
pteridyl
methyl
Prior art date
Application number
IT2116574A
Other languages
Italian (it)
Inventor
Duvaz Ion Niculescu
Liviu Valentin Feyns
Dan Suster
Gheorghe Diustea
Original Assignee
Inst Oncologic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Oncologic filed Critical Inst Oncologic
Priority to IT2116574A priority Critical patent/IT1058284B/en
Application granted granted Critical
Publication of IT1058284B publication Critical patent/IT1058284B/en

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Abstract

Prepn. of N p-( 2,4-4-diamino-6-pteridyl)-methyl -N10-methylamino)-benzoyl - -glutamic acid, (Ie, having formula involves (1) prepn. of 2,4-diamino-6-hydroxymethyl-pteridine (II) by reacting a salt (A) of 2.4,5,6-tetraamino-pyrimidine with the bisulphite (B) of 1,3-dihydroxyacetone in aq. medium, with addn. of air, using thioalcohols as catalysts and oxidn. agents, pref. SeO2; (2) halogenating (II) to 2,4-diamino-6-halomethyl-pteridine (III), with ahalogenating agent, pref, thionyl chloride or P oxychloride, in an inert medium, in presence of a basic catalyst, pref. pyridine or Net3, and (3) condensing (III) with N p-(N-methylamino)-benzoyl -glutamic acid (C) in a buffered aq. medium. Higher yields, e.g. 10-15% and purity >95% are obtd.
IT2116574A 1974-04-08 1974-04-08 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid IT1058284B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT2116574A IT1058284B (en) 1974-04-08 1974-04-08 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2116574A IT1058284B (en) 1974-04-08 1974-04-08 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

Publications (1)

Publication Number Publication Date
IT1058284B true IT1058284B (en) 1982-04-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
IT2116574A IT1058284B (en) 1974-04-08 1974-04-08 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

Country Status (1)

Country Link
IT (1) IT1058284B (en)

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