FR2270245A1 - Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid - Google Patents

Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

Info

Publication number
FR2270245A1
FR2270245A1 FR7410325A FR7410325A FR2270245A1 FR 2270245 A1 FR2270245 A1 FR 2270245A1 FR 7410325 A FR7410325 A FR 7410325A FR 7410325 A FR7410325 A FR 7410325A FR 2270245 A1 FR2270245 A1 FR 2270245A1
Authority
FR
France
Prior art keywords
diamino
methylamino
glutamic acid
pteridyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7410325A
Other languages
French (fr)
Other versions
FR2270245B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST ONCOLOGIC
Original Assignee
INST ONCOLOGIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST ONCOLOGIC filed Critical INST ONCOLOGIC
Priority to FR7410325A priority Critical patent/FR2270245A1/en
Publication of FR2270245A1 publication Critical patent/FR2270245A1/en
Application granted granted Critical
Publication of FR2270245B1 publication Critical patent/FR2270245B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Abstract

Prepn. of N p-( 2,4-4-diamino-6-pteridyl)-methyl -N10-methylamino)-benzoyl - -glutamic acid, (Ie, having formula involves (1) prepn. of 2,4-diamino-6-hydroxymethyl-pteridine (II) by reacting a salt (A) of 2.4,5,6-tetraamino-pyrimidine with the bisulphite (B) of 1,3-dihydroxyacetone in aq. medium, with addn. of air, using thioalcohols as catalysts and oxidn. agents, pref. SeO2; (2) halogenating (II) to 2,4-diamino-6-halomethyl-pteridine (III), with ahalogenating agent, pref, thionyl chloride or P oxychloride, in an inert medium, in presence of a basic catalyst, pref. pyridine or Net3, and (3) condensing (III) with N p-(N-methylamino)-benzoyl -glutamic acid (C) in a buffered aq. medium. Higher yields, e.g. 10-15% and purity >95% are obtd.
FR7410325A 1974-03-26 1974-03-26 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid Granted FR2270245A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7410325A FR2270245A1 (en) 1974-03-26 1974-03-26 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7410325A FR2270245A1 (en) 1974-03-26 1974-03-26 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

Publications (2)

Publication Number Publication Date
FR2270245A1 true FR2270245A1 (en) 1975-12-05
FR2270245B1 FR2270245B1 (en) 1978-04-21

Family

ID=9136818

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7410325A Granted FR2270245A1 (en) 1974-03-26 1974-03-26 Biologically active cpd used in cancer therapy - i.e. N-p-(2,4-diamino-6-pteridyl-methyl-nitrogen-10-methylamino-benzoy- l)-glutamic acid

Country Status (1)

Country Link
FR (1) FR2270245A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2371446A1 (en) * 1976-11-17 1978-06-16 Usa METHOD FOR PREPARING METHOTREXATE AND NEW PRODUCT THUS OBTAINED

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2371446A1 (en) * 1976-11-17 1978-06-16 Usa METHOD FOR PREPARING METHOTREXATE AND NEW PRODUCT THUS OBTAINED

Also Published As

Publication number Publication date
FR2270245B1 (en) 1978-04-21

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