IT1226270B - Substd 1-phenoxy -3-alkoxypropanol-2-by reaction of 3-alkoxy-1- - chloropropanol-2-with phenolate with - choleretic activity - Google Patents
Substd 1-phenoxy -3-alkoxypropanol-2-by reaction of 3-alkoxy-1- - chloropropanol-2-with phenolate with - choleretic activityInfo
- Publication number
- IT1226270B IT1226270B IT2110779A IT2110779A IT1226270B IT 1226270 B IT1226270 B IT 1226270B IT 2110779 A IT2110779 A IT 2110779A IT 2110779 A IT2110779 A IT 2110779A IT 1226270 B IT1226270 B IT 1226270B
- Authority
- IT
- Italy
- Prior art keywords
- chloropropanol
- alkoxypropanol
- substd
- phenolate
- phenoxy
- Prior art date
Links
- 230000001989 choleretic effect Effects 0.000 title abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-M phenolate Chemical compound [O-]C1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-M 0.000 title 1
- 229940031826 phenolate Drugs 0.000 title 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
- 229960004592 isopropanol Drugs 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000731 choleretic agent Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 abstract 1
- -1 trifluoromethyl methoxy, ethoxy Chemical group 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Cpds. of gen formula (I):- where R = alkyl (1-6C); R1 and R2 = H, methyl, trifluoromethyl methoxy, ethoxy, Cl or F; are prepd. by reacting a cpd. (II): Cl-CH2-CHOH-CH2OR with a cpd. where Me = alkali metal or ammonium. (I) have choleretic activity which is better than that of known choleretic agents and which are better tolerated. In an example KOH is dissolved in iso-propanol and 3-isopropoxy-1-chloropropanol-2 is added dropwise. Hydroquinone mono-methylether in isopropanol is then added while leading through N2, to give 72.9% of 3-isopropoxy-1(4'-methoxyphenoxy)-propanol-2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2110779A IT1226270B (en) | 1979-03-19 | 1979-03-19 | Substd 1-phenoxy -3-alkoxypropanol-2-by reaction of 3-alkoxy-1- - chloropropanol-2-with phenolate with - choleretic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2110779A IT1226270B (en) | 1979-03-19 | 1979-03-19 | Substd 1-phenoxy -3-alkoxypropanol-2-by reaction of 3-alkoxy-1- - chloropropanol-2-with phenolate with - choleretic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7921107A0 IT7921107A0 (en) | 1979-03-19 |
| IT1226270B true IT1226270B (en) | 1990-12-27 |
Family
ID=11176839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2110779A IT1226270B (en) | 1979-03-19 | 1979-03-19 | Substd 1-phenoxy -3-alkoxypropanol-2-by reaction of 3-alkoxy-1- - chloropropanol-2-with phenolate with - choleretic activity |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1226270B (en) |
-
1979
- 1979-03-19 IT IT2110779A patent/IT1226270B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT7921107A0 (en) | 1979-03-19 |
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