ES8602128A1 - Enzymatic synthesis of L-serine - Google Patents

Enzymatic synthesis of L-serine

Info

Publication number
ES8602128A1
ES8602128A1 ES527388A ES527388A ES8602128A1 ES 8602128 A1 ES8602128 A1 ES 8602128A1 ES 527388 A ES527388 A ES 527388A ES 527388 A ES527388 A ES 527388A ES 8602128 A1 ES8602128 A1 ES 8602128A1
Authority
ES
Spain
Prior art keywords
serine
enzymatic synthesis
biocatalytic
tetrahydrofolate
transferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527388A
Other languages
Spanish (es)
Other versions
ES527388A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genex Corp
Original Assignee
Genex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genex Corp filed Critical Genex Corp
Publication of ES527388A0 publication Critical patent/ES527388A0/en
Publication of ES8602128A1 publication Critical patent/ES8602128A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)

Abstract

A method of synthesizing L-serine from glycine and formaldehyde in the presence of biocatalytic amounts of serine hydroxymethyltransferase and tetrahydrofolate is disclosed. The serine hydroxymethyl- transferase may be amplified by cloning the gene therefor into a plasmid, and transforming a host cell, preferably Escherichia coli, Salmonella tymphimurium or Klebsiella aerogenes therewith.
ES527388A 1982-11-19 1983-11-18 Enzymatic synthesis of L-serine Expired ES8602128A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44296282A 1982-11-19 1982-11-19

Publications (2)

Publication Number Publication Date
ES527388A0 ES527388A0 (en) 1985-04-16
ES8602128A1 true ES8602128A1 (en) 1985-04-16

Family

ID=23758887

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527388A Expired ES8602128A1 (en) 1982-11-19 1983-11-18 Enzymatic synthesis of L-serine

Country Status (20)

Country Link
JP (1) JPS59109187A (en)
AU (1) AU2149383A (en)
BE (1) BE898261A (en)
BR (1) BR8306301A (en)
CA (1) CA1217158A (en)
CH (1) CH657373A5 (en)
DE (1) DE3341763A1 (en)
DK (1) DK529583A (en)
ES (1) ES8602128A1 (en)
FI (1) FI834231A (en)
FR (1) FR2536415B1 (en)
GB (1) GB2130216B (en)
GR (1) GR79037B (en)
IL (1) IL70271A0 (en)
IT (1) IT8368213A0 (en)
LU (1) LU85096A1 (en)
NL (1) NL8303978A (en)
PL (1) PL244608A1 (en)
SE (1) SE8306351L (en)
ZA (1) ZA838642B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782021A (en) * 1984-02-17 1988-11-01 Mitsui Toatsu Chemicals, Inc. Method of producing L-serine
JPS60172293A (en) * 1984-02-17 1985-09-05 Mitsui Toatsu Chem Inc Preparation of l-serine
EP0165044A3 (en) * 1984-06-11 1987-09-30 Genex Corporation Method of reacting an aldehyde- containing compound with a nucleophilic compound
JPS6181775A (en) * 1984-08-30 1986-04-25 Rikagaku Kenkyusho Cultivation of microorganism
EP0185824A1 (en) * 1984-12-28 1986-07-02 Genex Corporation Stabilization of tetrahydrofolic acid and serine hydroxymethyltransferase in reaction mixtures for the enzymatic cynthesis of L-serine
WO1986005515A1 (en) * 1985-03-18 1986-09-25 Genex Corporation In vitro synthesis of l-tryptophan
US4810817A (en) * 1985-10-21 1989-03-07 W. R. Grace & Co. Aspartyl-beta substituted phenylalanine dipeptides
US4873359A (en) * 1985-10-21 1989-10-10 W. R. Grace & Co. - Conn. Process for preparing as partyl-phenylalanine dipeptides
US5102792A (en) * 1987-08-13 1992-04-07 W. R. Grace & Co.-Conn. Selective production of L-serine derivative isomers
NZ238342A (en) * 1990-06-04 1993-10-26 Univ Notre Dame Du Lac Preparation of beta-hydroxy-alphaamino acids useful as intermediates in the preparation of beta-lactam antibiotics
US5266468A (en) * 1990-06-04 1993-11-30 University Of Notre Dame Du Lac Process for preparing β-hydroxy-α amino acids
EP0628634A3 (en) * 1993-05-25 1995-09-06 Lilly Co Eli Process for preparing serine hydroxymethyltransferase.
DE10106461A1 (en) * 2001-02-13 2002-08-14 Degussa Process for the fermentative production of D-pantothenic acid and / or its salts
CN104946695B (en) * 2015-06-03 2018-07-24 武汉轻工大学 A kind of preparation method of Serine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS582677B2 (en) * 1976-02-12 1983-01-18 田辺製薬株式会社 Production method of L-serine
GB2084155B (en) * 1980-09-17 1984-01-11 Grace W R & Co Process for production of l-amino acids using immobilized microorganisms

Also Published As

Publication number Publication date
FR2536415B1 (en) 1987-06-26
PL244608A1 (en) 1984-09-24
SE8306351D0 (en) 1983-11-17
LU85096A1 (en) 1984-04-02
IT8368213A0 (en) 1983-11-18
FR2536415A1 (en) 1984-05-25
DK529583A (en) 1984-05-20
DE3341763A1 (en) 1984-10-04
CA1217158A (en) 1987-01-27
CH657373A5 (en) 1986-08-29
GB2130216B (en) 1986-04-16
FI834231A0 (en) 1983-11-18
GB2130216A (en) 1984-05-31
ES527388A0 (en) 1985-04-16
FI834231A (en) 1984-05-20
SE8306351L (en) 1984-05-20
IL70271A0 (en) 1984-02-29
ZA838642B (en) 1984-07-25
NL8303978A (en) 1984-06-18
JPS59109187A (en) 1984-06-23
GR79037B (en) 1984-10-02
AU2149383A (en) 1984-05-24
BE898261A (en) 1984-03-16
BR8306301A (en) 1984-07-03
GB8330859D0 (en) 1983-12-29
DK529583D0 (en) 1983-11-18

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