ES8602112A1 - Procedimiento para preparar un polipeptido ciclico - Google Patents

Procedimiento para preparar un polipeptido ciclico

Info

Publication number
ES8602112A1
ES8602112A1 ES539678A ES539678A ES8602112A1 ES 8602112 A1 ES8602112 A1 ES 8602112A1 ES 539678 A ES539678 A ES 539678A ES 539678 A ES539678 A ES 539678A ES 8602112 A1 ES8602112 A1 ES 8602112A1
Authority
ES
Spain
Prior art keywords
alpha
amylase
activity
preparation
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539678A
Other languages
English (en)
Other versions
ES539678A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES539678A0 publication Critical patent/ES539678A0/es
Publication of ES8602112A1 publication Critical patent/ES8602112A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN POLIPEPTIDO CICLICO. CONSISTE EN CULTIVAR UN ESTREPTOMICETO, QUE GENERA EL POLIPEPTIDO, EN UN MEDIO DE FERMENTACION, SEGUN EL PROCEDIMIENTO SUMERGIDO, A UNA TEMPERATURA ENTRE 10 Y 40C, EN UN MEDIO CON UN PH ENTRE 4 Y 9 ACTIVADOR DEL CRECIMIENTO DE LOS MICROORGANISMOS, DURANTE 2 A 10 DIAS, Y SE AISLA EL POLIPEPTIDO A PARTIR DEL NUCLEO O DEL FILTRADO DE CULTIVO Y SE PURIFICA, PARA OBTENER UN POLIPEPTIDO CICLICO CON 10 A 200 AMINOACIDOS DE FORMULA (I). SIENDO: A GLU, ASN O MET; AS ES UNA CADENA DE POLIPEPTIDO CON 5 A 25 AMINOACIDOS NATURALES; S ES SER O THR; Y ES PHE, TYR O ASN. SE UTILIZA PARA PREPARAR POLIPEPTIDOS CICLICOS BIOLOGICAMENTE ACTIVOS, PARA LA DISGNOSIS MEDICINAL Y EN LA BIOTECNOLOGIA DEL ALMIDON.
ES539678A 1984-01-21 1985-01-18 Procedimiento para preparar un polipeptido ciclico Expired ES8602112A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3402021 1984-01-21

Publications (2)

Publication Number Publication Date
ES539678A0 ES539678A0 (es) 1985-11-16
ES8602112A1 true ES8602112A1 (es) 1985-11-16

Family

ID=6225535

Family Applications (1)

Application Number Title Priority Date Filing Date
ES539678A Expired ES8602112A1 (es) 1984-01-21 1985-01-18 Procedimiento para preparar un polipeptido ciclico

Country Status (17)

Country Link
US (1) US4623714A (es)
EP (1) EP0151246B1 (es)
JP (1) JPS60152500A (es)
KR (1) KR850005454A (es)
AT (1) ATE56728T1 (es)
AU (1) AU580973B2 (es)
CA (1) CA1230841A (es)
DE (1) DE3483260D1 (es)
DK (1) DK520784A (es)
ES (1) ES8602112A1 (es)
FI (1) FI844289L (es)
GR (1) GR80840B (es)
HU (1) HU192495B (es)
IL (1) IL73472A0 (es)
NO (1) NO844422L (es)
PT (1) PT79840B (es)
ZA (1) ZA848651B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3508384A1 (de) * 1985-03-08 1986-11-06 Boehringer Mannheim Gmbh, 6800 Mannheim Hemmung humaner speichel- und pankreasamylase durch monoklonale antikoerper
TW381025B (en) * 1993-08-05 2000-02-01 Hoffmann La Roche Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
CA2546601A1 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005308575A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
EP2571860A1 (en) 2010-05-21 2013-03-27 Pfizer Inc 2-phenyl benzoylamides
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2014513923A (ja) 2011-03-04 2014-06-19 ファイザー・インク Ｅｄｎ３様ペプチドおよびその使用
US20150050371A1 (en) 2012-03-09 2015-02-19 Biotropics Malaysia Berhad Extract Formulations of Rhodamnia Cinerea And Uses Thereof
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
KR101695582B1 (ko) 2013-04-17 2017-01-13 화이자 인코포레이티드 심혈관 질환을 치료하기 위한 n-피페리딘-3-일벤즈아미드 유도체
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
ES2901114T3 (es) 2014-08-29 2022-03-21 Tes Pharma S R L Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
AU2019385644A1 (en) 2018-11-20 2021-06-03 Tes Pharma S.R.L. Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2701890C2 (de) * 1977-01-19 1983-08-04 Hoechst Ag, 6230 Frankfurt Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung
DE2716050A1 (de) * 1977-04-09 1978-10-19 Hoechst Ag Alpha-amylase-inhibitor aus einem streptomyceten und verfahren zu seiner gewinnung
ES505959A0 (es) * 1980-10-09 1982-09-01 Hoechst Ag Procedimiento para la preparacion de un inactivador de alfa-amilasa

Also Published As

Publication number Publication date
AU3519084A (en) 1985-07-25
JPS60152500A (ja) 1985-08-10
AU580973B2 (en) 1989-02-09
PT79840A (en) 1985-02-01
US4623714A (en) 1986-11-18
FI844289L (fi) 1985-07-22
ES539678A0 (es) 1985-11-16
PT79840B (en) 1986-11-14
DE3483260D1 (de) 1990-10-25
DK520784D0 (da) 1984-11-01
KR850005454A (ko) 1985-08-26
DK520784A (da) 1985-07-22
ATE56728T1 (de) 1990-10-15
HU192495B (en) 1987-06-29
NO844422L (no) 1985-07-22
GR80840B (en) 1985-02-26
EP0151246B1 (de) 1990-09-19
FI844289A0 (fi) 1984-11-01
EP0151246A2 (de) 1985-08-14
CA1230841A (en) 1987-12-29
EP0151246A3 (en) 1987-05-27
ZA848651B (en) 1985-06-26
IL73472A0 (en) 1985-02-28
HUT37657A (en) 1986-01-23

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