ES8601959A1 - Procedimiento para la obtencion de derivados de benzodioxol - Google Patents

Procedimiento para la obtencion de derivados de benzodioxol

Info

Publication number
ES8601959A1
ES8601959A1 ES526609A ES526609A ES8601959A1 ES 8601959 A1 ES8601959 A1 ES 8601959A1 ES 526609 A ES526609 A ES 526609A ES 526609 A ES526609 A ES 526609A ES 8601959 A1 ES8601959 A1 ES 8601959A1
Authority
ES
Spain
Prior art keywords
radical
compound
general formula
alk
given above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526609A
Other languages
English (en)
Other versions
ES526609A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES526609A0 publication Critical patent/ES526609A0/es
Publication of ES8601959A1 publication Critical patent/ES8601959A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Light Receiving Elements (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Waveguide Switches, Polarizers, And Phase Shifters (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENZODIOXOL. CONSISTE EN HACER REACCIONAR EL COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER EL COMPUESTO DE FORMULA (I) O SUS SALES FARMACOLOGICAMENTE ACEPTABLES, EN CUYO CASO LA REACCION SE HARA EN PRESENCIA DE LOS ACIDOS CONVENIENTES. SIENDO: A, EL RESTO -O- R5; R1, RRESTO ALIFATICO, RESTO AROMATICO Y OTROS; R2, R3, R4, INDEPENDIENTEMENTE, H ALQUILO INFERIOR, ALCOXI INFERIOR, O HALOGENO; R5, H, HIDROCARBURO ALIFATICO O ARALIFATICO O R6-N-R7; R6 Y R7, H O ALQUILO INFERIOR, INDEPENDIENTEMENTE; N1 ES 0, 1 O 2; Y N2 ES 0 O 1. SE UTILIZA COMO DIURETICO Y SODIODIURETICO EN ROEDORES, CANES Y SIMIOS.
ES526609A 1982-10-22 1983-10-20 Procedimiento para la obtencion de derivados de benzodioxol Expired ES8601959A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH616382 1982-10-22

Publications (2)

Publication Number Publication Date
ES526609A0 ES526609A0 (es) 1985-11-16
ES8601959A1 true ES8601959A1 (es) 1985-11-16

Family

ID=4305256

Family Applications (5)

Application Number Title Priority Date Filing Date
ES526609A Expired ES8601959A1 (es) 1982-10-22 1983-10-20 Procedimiento para la obtencion de derivados de benzodioxol
ES543682A Expired ES8608506A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol
ES543684A Expired ES8703450A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol
ES543683A Expired ES8703449A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol
ES543681A Expired ES8603860A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES543682A Expired ES8608506A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol
ES543684A Expired ES8703450A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol
ES543683A Expired ES8703449A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol
ES543681A Expired ES8603860A1 (es) 1982-10-22 1985-05-30 Procedimiento para la obtencion de derivados del benzodioxol

Country Status (16)

Country Link
EP (1) EP0107622B1 (es)
JP (1) JPS5995284A (es)
AT (1) ATE30722T1 (es)
AU (1) AU567894B2 (es)
CA (1) CA1223874A (es)
DE (1) DE3374408D1 (es)
DK (1) DK485583A (es)
ES (5) ES8601959A1 (es)
FI (1) FI833819A (es)
GR (1) GR78709B (es)
IE (1) IE56092B1 (es)
IL (1) IL70005A0 (es)
NO (1) NO833857L (es)
NZ (1) NZ206035A (es)
PT (1) PT77539B (es)
ZA (1) ZA837811B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158596A3 (de) * 1984-04-06 1986-08-13 Ciba-Geigy Ag Neue substituierte Benzodioxolderivate, Verfahren zu deren Herstellung und entsprechende pharmazeutische Zusammensetzungen
US6169107B1 (en) 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
AR052319A1 (es) 2004-10-29 2007-03-14 Kalypsys Inc Compuestos biciclicos sustituidos por sulfonilo en funcion de moduladores del ppar
BRPI0619282B8 (pt) * 2005-10-25 2021-05-25 Kalypsys Inc sal, e composição farmacêutica
CN101007798B (zh) * 2006-01-24 2011-01-26 中国人民解放军军事医学科学院毒物药物研究所 苯并间二氧杂环戊烯衍生物及其制备方法和医药用途
CN101007804B (zh) * 2006-01-25 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 1,3-苯并间二氧杂环戊烯-2,2-二羧酸衍生物、其制备方法和医疗用途
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2012045646A1 (en) * 2010-10-04 2012-04-12 Firmenich Sa Benzodioxole derivatives as watery odorants

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872105A (en) * 1973-06-11 1975-03-18 Merrell Inc Richard Derivatives of 1,3-benzodioxole-2-carboxylic acid
GR75464B (es) * 1981-04-24 1984-07-20 Ciba Geigy
EP0107623A1 (de) * 1982-10-22 1984-05-02 Ciba-Geigy Ag Neue Benzodioxolderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
ES543681A0 (es) 1986-01-01
ES543682A0 (es) 1986-06-16
PT77539B (en) 1986-05-28
ATE30722T1 (de) 1987-11-15
GR78709B (es) 1984-09-27
ZA837811B (en) 1984-08-29
PT77539A (en) 1983-11-01
ES526609A0 (es) 1985-11-16
JPS5995284A (ja) 1984-06-01
NZ206035A (en) 1987-03-06
CA1223874A (en) 1987-07-07
NO833857L (no) 1984-04-24
DK485583D0 (da) 1983-10-21
IE56092B1 (en) 1991-04-10
EP0107622A1 (de) 1984-05-02
EP0107622B1 (de) 1987-11-11
FI833819A0 (fi) 1983-10-19
ES8603860A1 (es) 1986-01-01
IE832472L (en) 1984-04-22
IL70005A0 (en) 1984-01-31
ES543684A0 (es) 1987-02-16
DE3374408D1 (en) 1987-12-17
ES8608506A1 (es) 1986-06-16
FI833819A (fi) 1984-04-23
ES8703449A1 (es) 1987-02-16
ES8703450A1 (es) 1987-02-16
AU2048983A (en) 1984-05-03
DK485583A (da) 1984-04-23
AU567894B2 (en) 1987-12-10
ES543683A0 (es) 1987-02-16

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