ES8601234A1 - Procedimiento para la obtencion de un ester de acido carboxilico - Google Patents

Procedimiento para la obtencion de un ester de acido carboxilico

Info

Publication number
ES8601234A1
ES8601234A1 ES535242A ES535242A ES8601234A1 ES 8601234 A1 ES8601234 A1 ES 8601234A1 ES 535242 A ES535242 A ES 535242A ES 535242 A ES535242 A ES 535242A ES 8601234 A1 ES8601234 A1 ES 8601234A1
Authority
ES
Spain
Prior art keywords
steroids
carboxylic acid
acid esters
cpd
hcl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535242A
Other languages
English (en)
Other versions
ES535242A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES535242A0 publication Critical patent/ES535242A0/es
Publication of ES8601234A1 publication Critical patent/ES8601234A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Fats And Perfumes (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DE ACIDO CARBOXILICO DE FORMULA (I) EN LA QUE R REPRESENTA ALQUILO CON 1 A 4 ATOMOS DE CARBONO. CONSISTE EN LA REACCION DE UN COMPUESTO 9B11B-OXO DE FORMULA (II) EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) CON CLORURO DE HIDROGENO O UN MEDIO QUE LIBERA CLORURO DE HIDROGENO. LA REACCION SE LLEVA A CABO EN MEDIO ANHIDRO EN UN DISOLVENTE INERTE A LA TEMPERATURA AMBIENTE. TAMBIEN SE PUEDEN OBTENER LOS COMPUESTOS DE FORMULA (I) TRATANDO OTROS COMPUESTOS DE PARTIDA SEGUN METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFICACIA ANTIINFLAMATORIA.
ES535242A 1983-08-18 1984-08-17 Procedimiento para la obtencion de un ester de acido carboxilico Expired ES8601234A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH451283 1983-08-18

Publications (2)

Publication Number Publication Date
ES535242A0 ES535242A0 (es) 1985-11-01
ES8601234A1 true ES8601234A1 (es) 1985-11-01

Family

ID=4277476

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535242A Expired ES8601234A1 (es) 1983-08-18 1984-08-17 Procedimiento para la obtencion de un ester de acido carboxilico

Country Status (21)

Country Link
US (1) US4607028A (es)
EP (1) EP0135476B1 (es)
JP (1) JPS6058999A (es)
KR (1) KR850001725A (es)
AT (1) ATE37186T1 (es)
AU (1) AU3204484A (es)
CA (1) CA1234564A (es)
CY (1) CY1593A (es)
DD (1) DD227966A5 (es)
DE (1) DE3474025D1 (es)
DK (1) DK160993C (es)
ES (1) ES8601234A1 (es)
FI (1) FI80888C (es)
GR (1) GR80131B (es)
HK (1) HK42791A (es)
HU (1) HUT34991A (es)
IL (1) IL72702A0 (es)
NO (1) NO160212C (es)
PT (1) PT79106B (es)
SG (1) SG32091G (es)
ZA (1) ZA846406B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
AU5640390A (en) * 1989-06-16 1991-01-08 Upjohn Company, The Suramin type compounds and angiostatic steroids to inhibit angiogenesis
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
JPH07119308A (ja) * 1993-10-27 1995-05-09 Koa:Kk 移動作業床による外壁貼りの吊り支え工法並にその装置
GB9501286D0 (en) * 1995-01-24 1995-03-15 Ciba Geigy Ag Pharmaceutical compositions and preparations thereof
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
AUPP583198A0 (en) * 1998-09-11 1998-10-01 Soltec Research Pty Ltd Mousse composition
GB0015876D0 (en) * 2000-06-28 2000-08-23 Novartis Ag Organic compounds
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
SI1775305T1 (sl) * 2000-08-05 2015-01-30 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
GB0029562D0 (en) * 2000-12-04 2001-01-17 Novartis Ag Organic compounds
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
SI1383786T1 (sl) * 2001-04-30 2009-02-28 Glaxo Group Ltd Protivnetni 17.beta-karbotioatestrski derivati androstana s ciklično estrsko skupino na položaju 17.alfa
GB0202216D0 (en) * 2002-01-31 2002-03-20 Glaxo Group Ltd Novel compounds
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
JPS5297597A (en) * 1976-02-09 1977-08-16 Walt Disney Prod Guide device of ship
JPS5938239B2 (ja) * 1976-02-12 1984-09-14 グラクソ・ラボラトリ−ス・リミテツド 新規ステロイド化合物
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
CH634081A5 (en) * 1977-04-13 1983-01-14 Ciba Geigy Ag Process for the preparation of novel androstadiene-17beta-carboxylic acid esters
ZA814440B (en) * 1980-07-10 1982-10-27 Otsuka Pharma Co Ltd Soft steroids having anti-inflammatory activity

Also Published As

Publication number Publication date
IL72702A0 (en) 1984-11-30
DK160993C (da) 1991-11-04
DD227966A5 (de) 1985-10-02
EP0135476A2 (de) 1985-03-27
FI80888B (fi) 1990-04-30
DK160993B (da) 1991-05-13
DE3474025D1 (en) 1988-10-20
CY1593A (en) 1992-04-03
HUT34991A (en) 1985-05-28
ES535242A0 (es) 1985-11-01
KR850001725A (ko) 1985-04-01
NO160212B (no) 1988-12-12
ZA846406B (en) 1985-03-27
AU3204484A (en) 1985-02-21
SG32091G (en) 1991-06-21
CA1234564A (en) 1988-03-29
FI80888C (fi) 1990-08-10
US4607028A (en) 1986-08-19
EP0135476B1 (de) 1988-09-14
FI843219A (fi) 1985-02-19
PT79106A (en) 1984-09-01
NO843298L (no) 1985-02-19
JPH0253440B2 (es) 1990-11-16
EP0135476A3 (en) 1985-12-18
FI843219A0 (fi) 1984-08-15
NO160212C (no) 1989-03-22
HK42791A (en) 1991-06-07
GR80131B (en) 1984-12-19
DK396284D0 (da) 1984-08-17
JPS6058999A (ja) 1985-04-05
PT79106B (en) 1986-11-14
ATE37186T1 (de) 1988-09-15
DK396284A (da) 1985-02-19

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