ES8601198A1 - Un procedimiento para la preparacion de benzoquinolicinas - Google Patents
Un procedimiento para la preparacion de benzoquinolicinasInfo
- Publication number
- ES8601198A1 ES8601198A1 ES530973A ES530973A ES8601198A1 ES 8601198 A1 ES8601198 A1 ES 8601198A1 ES 530973 A ES530973 A ES 530973A ES 530973 A ES530973 A ES 530973A ES 8601198 A1 ES8601198 A1 ES 8601198A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- alkyl
- different
- same
- benzoquinolizines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SSSYOIPHXANRMO-UHFFFAOYSA-N 4h-benzo[a]quinolizine Chemical class C1=CC=C2C3=CC=CCN3C=CC2=C1 SSSYOIPHXANRMO-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000015006 alpha2-adrenergic receptor activity proteins Human genes 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE BENZOQUINOLICINAS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I) EN LA QUE R ES HIDROGENO O ALQUILO INFERIOR; A ES ALQUILENO C1-3; Y R1 R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN DERIVADO REACTIVO DE UN ACIDO SULFONICO DE FORMULA R3SO2OH CON UNA BENZOQUINOLICINA DE FORMULA (II) EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE EN PRESENCIA DE UNA BASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIDEPRESIVOS EN EL TRATAMIENTO DE LA DIABETES Y EN LA INHIBICION DE AGREGACION DE PLAQUETAS EN LA SANGRE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838308321A GB8308321D0 (en) | 1983-03-25 | 1983-03-25 | Benzoquinolizines |
GB838333232A GB8333232D0 (en) | 1983-12-13 | 1983-12-13 | Benzoquinolizines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8601198A1 true ES8601198A1 (es) | 1985-11-01 |
ES530973A0 ES530973A0 (es) | 1985-11-01 |
Family
ID=26285623
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530973A Granted ES530973A0 (es) | 1983-03-25 | 1984-03-24 | Un procedimiento para la preparacion de benzoquinolicinas |
ES544251A Expired ES8604219A1 (es) | 1983-03-25 | 1985-06-17 | Un procedimiento para la preparacion de benzoquinolicinas |
ES544250A Expired ES8604218A1 (es) | 1983-03-25 | 1985-06-17 | Un procedimiento para la preparacion de benzoquinolicinas |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544251A Expired ES8604219A1 (es) | 1983-03-25 | 1985-06-17 | Un procedimiento para la preparacion de benzoquinolicinas |
ES544250A Expired ES8604218A1 (es) | 1983-03-25 | 1985-06-17 | Un procedimiento para la preparacion de benzoquinolicinas |
Country Status (17)
Country | Link |
---|---|
US (1) | US4526967A (es) |
EP (1) | EP0120637B1 (es) |
KR (1) | KR910003151B1 (es) |
AR (2) | AR240819A1 (es) |
AU (1) | AU568553B2 (es) |
CA (1) | CA1247622A (es) |
DE (1) | DE3468877D1 (es) |
DK (1) | DK160873C (es) |
ES (3) | ES530973A0 (es) |
FI (1) | FI77031C (es) |
GB (1) | GB2136804B (es) |
GR (1) | GR81892B (es) |
HU (1) | HU199835B (es) |
IE (1) | IE57014B1 (es) |
PH (2) | PH20377A (es) |
PT (1) | PT78292B (es) |
WO (1) | WO1984003702A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8420602D0 (en) * | 1984-08-14 | 1984-09-19 | Wyeth John & Brother Ltd | Thienoquinolizines |
US4710504A (en) * | 1986-04-04 | 1987-12-01 | Merck & Co., Inc. | Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor |
US4824849A (en) * | 1985-06-03 | 1989-04-25 | Merck & Co., Inc. | α2 -adrenoceptor antagonistic arylquinolizines |
AU582663B2 (en) * | 1985-08-10 | 1989-04-06 | John Wyeth & Brother Limited | Sulphonamides |
NZ221485A (en) * | 1986-08-28 | 1991-04-26 | Merck & Co Inc | Hexahydroarylquinolizine derivatives and pharmaceutical compositions |
US4831035A (en) * | 1986-08-28 | 1989-05-16 | Merck & Co., Inc. | Substituted hexahydroarylquinolizines |
CA1321751C (en) * | 1989-02-21 | 1993-08-31 | Eugene C. Crichlow | Mechanism mediating ruminal stasis in ruminal lactic acidosis |
IT1286545B1 (it) | 1996-02-09 | 1998-07-15 | Antonio Guarna | Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi |
DE19948194C2 (de) | 1999-10-06 | 2001-11-08 | Aloys Wobben | Verfahren zur Überwachung von Windenergieanlagen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4154139A (en) * | 1971-12-15 | 1979-05-15 | M.C.P. Industries, Inc. | Screw threaded fastening means and like products |
GB1513824A (en) * | 1975-05-22 | 1978-06-14 | Wyeth John & Brother Ltd | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative |
GB2083029B (en) * | 1980-08-28 | 1983-09-28 | Wyeth John & Brother Ltd | Benzoquinolizines |
IE51467B1 (en) * | 1980-08-28 | 1986-12-24 | Wyeth John & Brother Ltd | Benzoquinolizines |
GB2106909B (en) * | 1981-10-07 | 1984-09-19 | Wyeth John & Brother Ltd | Benzoquinolizines |
-
1984
- 1984-03-05 IE IE526/84A patent/IE57014B1/en not_active IP Right Cessation
- 1984-03-07 CA CA000449054A patent/CA1247622A/en not_active Expired
- 1984-03-09 DE DE8484301583T patent/DE3468877D1/de not_active Expired
- 1984-03-09 EP EP84301583A patent/EP0120637B1/en not_active Expired
- 1984-03-09 GB GB08406283A patent/GB2136804B/en not_active Expired
- 1984-03-12 GR GR74079A patent/GR81892B/el unknown
- 1984-03-13 AR AR295987A patent/AR240819A1/es active
- 1984-03-19 WO PCT/GB1984/000086 patent/WO1984003702A1/en active IP Right Grant
- 1984-03-19 AU AU26929/84A patent/AU568553B2/en not_active Ceased
- 1984-03-19 US US06/590,653 patent/US4526967A/en not_active Expired - Lifetime
- 1984-03-19 HU HU841809A patent/HU199835B/hu not_active IP Right Cessation
- 1984-03-20 PH PH30419A patent/PH20377A/en unknown
- 1984-03-22 PT PT78292A patent/PT78292B/pt not_active IP Right Cessation
- 1984-03-24 KR KR1019840001518A patent/KR910003151B1/ko not_active IP Right Cessation
- 1984-03-24 ES ES530973A patent/ES530973A0/es active Granted
- 1984-11-14 DK DK540684A patent/DK160873C/da not_active IP Right Cessation
- 1984-11-19 FI FI844535A patent/FI77031C/fi not_active IP Right Cessation
-
1985
- 1985-05-24 PH PH32311A patent/PH20491A/en unknown
- 1985-06-17 ES ES544251A patent/ES8604219A1/es not_active Expired
- 1985-06-17 ES ES544250A patent/ES8604218A1/es not_active Expired
-
1986
- 1986-03-18 AR AR303415A patent/AR240937A1/es active
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