AR240819A2 - Procedimiento para preparar una benzoquinolicina - Google Patents

Procedimiento para preparar una benzoquinolicina

Info

Publication number
AR240819A2
AR240819A2 AR29598784A AR29598784A AR240819A2 AR 240819 A2 AR240819 A2 AR 240819A2 AR 29598784 A AR29598784 A AR 29598784A AR 29598784 A AR29598784 A AR 29598784A AR 240819 A2 AR240819 A2 AR 240819A2
Authority
AR
Argentina
Prior art keywords
alkyl
formula
same
pharmaceutically acceptable
phenyl
Prior art date
Application number
AR29598784A
Other languages
English (en)
Other versions
AR240819A1 (es
Original Assignee
John Wyth E Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838308321A external-priority patent/GB8308321D0/en
Priority claimed from GB838333232A external-priority patent/GB8333232D0/en
Application filed by John Wyth E Brother Ltd filed Critical John Wyth E Brother Ltd
Application granted granted Critical
Publication of AR240819A2 publication Critical patent/AR240819A2/es
Publication of AR240819A1 publication Critical patent/AR240819A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Abstract

UN PROCEDIMIENTO PARA PREPARAR UNA BENZOQUINOLICINA DE LA FORMULA GENERAL (I) O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DE LA MISMA, EN DONDE R REPRESENTA HIDROGENO O ALQUILO, R1 Y R2 QUE PUEDEN SER IGUALES O DISTINTOS REPRESENTAN CADA UNO HIDROGENO, ALQUILO O ALCOXILO, R3 Y R4 QUE PUEDEN SER IGUALES O DISTINTOS REPRESENTAN, CADA UNO, ALQUILO, HALOMETILO, FENILO, ALQUIL FENILO, ALCOXI FENILO, HALOFENILO O NITROFENILO, Y A REPRESENTA UN GRUPO ALQUILENO EN LA CADENA ENTRE LOS DOS ATOMOS DE N. SE HACE REACCIONAR UN HALURO O ANHIDRIDO DE UN ACIDO SULFONICO DE LA FORMULA R5SO2OH EN DONDE R5 TIENE LOS MISMOS SIGNIFICADOS ANTES INDICADOS PARA R3 Y R4, A UNA TEMPERATURA DENTRO DE LA GAMA DE -20{C A 100{C CON UNA BENZOQUINOLICINA DE LA FORMULA GENERAL (II) EN DONDE R1 Y R2 TIENEN EL SIGNIFICADO ANTES INDICADO Y Z REPRESENTA -NH.A.NHR, -NH.A.NRSO2R4 O -N(SO2R3).A.NH2 DONDE R Y R4 TIENEN LOS SIGNIFICADOS ANTES INDICADOS Y, SI SE DESEA, SEPARAR UNA MEZCLA DE ISOMERO DE FORMULA (I) O CONVERTIR UNA BASE LIBRE DE FORMULA (I) EN UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LA MISMA.
AR295987A 1983-03-25 1984-03-13 Procedimiento para preparar una benzoquinolicina AR240819A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838308321A GB8308321D0 (en) 1983-03-25 1983-03-25 Benzoquinolizines
GB838333232A GB8333232D0 (en) 1983-12-13 1983-12-13 Benzoquinolizines

Publications (2)

Publication Number Publication Date
AR240819A2 true AR240819A2 (es) 1991-02-28
AR240819A1 AR240819A1 (es) 1991-02-28

Family

ID=26285623

Family Applications (2)

Application Number Title Priority Date Filing Date
AR295987A AR240819A1 (es) 1983-03-25 1984-03-13 Procedimiento para preparar una benzoquinolicina
AR303415A AR240937A1 (es) 1983-03-25 1986-03-18 Procedimiento para preparar una benzoquinolicina

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR303415A AR240937A1 (es) 1983-03-25 1986-03-18 Procedimiento para preparar una benzoquinolicina

Country Status (17)

Country Link
US (1) US4526967A (es)
EP (1) EP0120637B1 (es)
KR (1) KR910003151B1 (es)
AR (2) AR240819A1 (es)
AU (1) AU568553B2 (es)
CA (1) CA1247622A (es)
DE (1) DE3468877D1 (es)
DK (1) DK160873C (es)
ES (3) ES8601198A1 (es)
FI (1) FI77031C (es)
GB (1) GB2136804B (es)
GR (1) GR81892B (es)
HU (1) HU199835B (es)
IE (1) IE57014B1 (es)
PH (2) PH20377A (es)
PT (1) PT78292B (es)
WO (1) WO1984003702A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8420602D0 (en) * 1984-08-14 1984-09-19 Wyeth John & Brother Ltd Thienoquinolizines
US4710504A (en) * 1986-04-04 1987-12-01 Merck & Co., Inc. Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor
US4824849A (en) * 1985-06-03 1989-04-25 Merck & Co., Inc. α2 -adrenoceptor antagonistic arylquinolizines
AU582663B2 (en) * 1985-08-10 1989-04-06 John Wyeth & Brother Limited Sulphonamides
US4831035A (en) * 1986-08-28 1989-05-16 Merck & Co., Inc. Substituted hexahydroarylquinolizines
NZ221485A (en) * 1986-08-28 1991-04-26 Merck & Co Inc Hexahydroarylquinolizine derivatives and pharmaceutical compositions
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
IT1286545B1 (it) 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
DE19948194C2 (de) 1999-10-06 2001-11-08 Aloys Wobben Verfahren zur Überwachung von Windenergieanlagen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154139A (en) * 1971-12-15 1979-05-15 M.C.P. Industries, Inc. Screw threaded fastening means and like products
GB1513824A (en) * 1975-05-22 1978-06-14 Wyeth John & Brother Ltd 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
GB2083029B (en) * 1980-08-28 1983-09-28 Wyeth John & Brother Ltd Benzoquinolizines
IE51467B1 (en) * 1980-08-28 1986-12-24 Wyeth John & Brother Ltd Benzoquinolizines
GB2106909B (en) * 1981-10-07 1984-09-19 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
PT78292A (en) 1984-04-01
EP0120637A1 (en) 1984-10-03
KR840008360A (ko) 1984-12-14
EP0120637B1 (en) 1988-01-20
ES544251A0 (es) 1986-01-16
ES8604218A1 (es) 1986-01-16
FI844535A0 (fi) 1984-11-19
HUT36474A (en) 1985-09-30
GB2136804A (en) 1984-09-26
AR240937A2 (en) 1991-03-27
AU568553B2 (en) 1988-01-07
IE57014B1 (en) 1992-03-11
ES530973A0 (es) 1985-11-01
PH20377A (en) 1986-12-08
GB8406283D0 (en) 1984-04-11
DK160873C (da) 1991-10-14
DK160873B (da) 1991-04-29
AR240937A1 (es) 1991-03-27
PT78292B (en) 1986-04-22
ES544250A0 (es) 1986-01-16
AU2692984A (en) 1984-10-09
PH20491A (en) 1987-01-21
WO1984003702A1 (en) 1984-09-27
ES8604219A1 (es) 1986-01-16
DK540684D0 (da) 1984-11-14
KR910003151B1 (ko) 1991-05-20
FI77031B (fi) 1988-09-30
DE3468877D1 (de) 1988-02-25
US4526967A (en) 1985-07-02
IE840526L (en) 1984-09-25
ES8601198A1 (es) 1985-11-01
GR81892B (es) 1984-12-12
GB2136804B (en) 1987-08-05
CA1247622A (en) 1988-12-28
DK540684A (da) 1984-11-14
HU199835B (en) 1990-03-28
FI844535L (fi) 1984-11-19
AR240819A1 (es) 1991-02-28
FI77031C (fi) 1989-01-10

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