ES8600736A1 - Procedimiento para la preparacion de derivados indanilicos - Google Patents

Procedimiento para la preparacion de derivados indanilicos

Info

Publication number
ES8600736A1
ES8600736A1 ES537971A ES537971A ES8600736A1 ES 8600736 A1 ES8600736 A1 ES 8600736A1 ES 537971 A ES537971 A ES 537971A ES 537971 A ES537971 A ES 537971A ES 8600736 A1 ES8600736 A1 ES 8600736A1
Authority
ES
Spain
Prior art keywords
preparation
indane derivatives
formula
image
indanyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537971A
Other languages
English (en)
Other versions
ES537971A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8600736A1 publication Critical patent/ES8600736A1/es
Publication of ES537971A0 publication Critical patent/ES537971A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus
    • C12R2001/685—Aspergillus niger

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS INDANILICOS DE FORMULA (I), EN LA QUE R1 Y R2 REPRESENTAN HIDROGENO, FLUOR O CLORO.CONSISTE EN LA FERMENTACION DE UN DERIVADO INDANILICO, DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), CON UN CULTIVO VIVO DE ASPERGILLUS NIGER O POLYPORUR TULIPIFERUS. LA FERMENTACION SE EFECTUA EN CONDICIONES AEROBICAS, EN UN MEDIO QUE CONTIENE 100 A 2.000 MG DE SUSTRATO POR LITRO DE MEDIO NUTRICIO, A UN VALOR DE PH ENTRE 5 Y 7 A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 40JC, Y CON UNA AIREACION DE 0,5 A 5 LITROS DE AIRE POR MINUTO Y POR LITRO DE CALDO DE CULTIVO.ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE ARTRITIS REUMATICA, OSTEOARTRITIS, ESPONDILITIS ANQUILOSANTE, ASMA BRONQUIAL Y FIEBRE DE HENO.
ES537971A 1983-11-28 1984-11-26 Procedimiento para la preparacion de derivados indanilicos Granted ES537971A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833343331 DE3343331A1 (de) 1983-11-28 1983-11-28 Verfahren zur herstellung von indanyl-derivaten und deren verwendung

Publications (2)

Publication Number Publication Date
ES8600736A1 true ES8600736A1 (es) 1985-11-01
ES537971A0 ES537971A0 (es) 1985-11-01

Family

ID=6215683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537971A Granted ES537971A0 (es) 1983-11-28 1984-11-26 Procedimiento para la preparacion de derivados indanilicos

Country Status (18)

Country Link
US (1) US4696948A (es)
EP (1) EP0143403B1 (es)
JP (1) JPS60199394A (es)
AT (1) ATE62511T1 (es)
AU (1) AU568701B2 (es)
CA (1) CA1245589A (es)
CS (1) CS244844B2 (es)
DD (1) DD229153A5 (es)
DE (2) DE3343331A1 (es)
DK (1) DK561484A (es)
ES (1) ES537971A0 (es)
FI (1) FI77893C (es)
GR (1) GR81056B (es)
HU (1) HU193238B (es)
IL (1) IL73657A (es)
NO (1) NO164845C (es)
PT (1) PT79556B (es)
ZA (1) ZA849287B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753725B2 (ja) * 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US5409944A (en) * 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
US5500359A (en) * 1993-09-27 1996-03-19 Solvay Enzymes, Inc. Method for producing a therapeautic composition for papillomavirus-induced tumors with aspergillus niger
US5968958A (en) * 1995-01-31 1999-10-19 Merck Frosst Canada, Inc. 5-Methanesulfonamido-3H-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009554B1 (de) * 1978-07-27 1983-04-27 Schering Aktiengesellschaft Indanyl-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
DE3103372A1 (de) * 1981-01-27 1982-09-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue indanyl-derivate, ihre herstellung und verwendung
DE3208079A1 (de) * 1982-03-04 1983-09-08 Schering AG, 1000 Berlin und 4709 Bergkamen Neue indanyl-derivate, ihre herstellung und verwendung

Also Published As

Publication number Publication date
IL73657A (en) 1987-10-30
IL73657A0 (en) 1985-02-28
DE3343331A1 (de) 1985-06-05
AU568701B2 (en) 1988-01-07
HUT36499A (en) 1985-09-30
FI844644A0 (fi) 1984-11-27
FI77893B (fi) 1989-01-31
EP0143403A3 (en) 1987-07-22
HU193238B (en) 1987-08-28
EP0143403B1 (de) 1991-04-10
NO164845B (no) 1990-08-13
NO164845C (no) 1990-11-21
NO844702L (no) 1985-05-29
DK561484A (da) 1985-05-29
FI844644L (fi) 1985-05-29
CA1245589A (en) 1988-11-29
ATE62511T1 (de) 1991-04-15
ZA849287B (en) 1985-07-31
DK561484D0 (da) 1984-11-27
GR81056B (en) 1985-03-26
AU3584484A (en) 1985-06-06
JPS60199394A (ja) 1985-10-08
ES537971A0 (es) 1985-11-01
EP0143403A2 (de) 1985-06-05
PT79556A (de) 1984-12-01
DE3484422D1 (de) 1991-05-16
US4696948A (en) 1987-09-29
PT79556B (de) 1986-09-15
DD229153A5 (de) 1985-10-30
FI77893C (fi) 1989-05-10
CS244844B2 (en) 1986-08-14
JPH054069B2 (es) 1993-01-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401