ES8507513A1 - Un procedimiento para preparar derivados bis-dioxopiperazinicos - Google Patents
Un procedimiento para preparar derivados bis-dioxopiperazinicosInfo
- Publication number
- ES8507513A1 ES8507513A1 ES537206A ES537206A ES8507513A1 ES 8507513 A1 ES8507513 A1 ES 8507513A1 ES 537206 A ES537206 A ES 537206A ES 537206 A ES537206 A ES 537206A ES 8507513 A1 ES8507513 A1 ES 8507513A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- carbon atoms
- substituted
- alkoxy
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- -1 alkyl radical Chemical class 0.000 abstract 11
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical class O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58204448A JPS6097963A (ja) | 1983-10-31 | 1983-10-31 | ビス−ジオキソピペラジン誘導体，その製造方法及びそれからなる抗腫瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES537206A0 ES537206A0 (es) | 1985-09-01 |
| ES8507513A1 true ES8507513A1 (es) | 1985-09-01 |
Family
ID=16490690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES537206A Expired ES8507513A1 (es) | 1983-10-31 | 1984-10-30 | Un procedimiento para preparar derivados bis-dioxopiperazinicos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4650799A (enExample) |
| EP (1) | EP0140327B1 (enExample) |
| JP (1) | JPS6097963A (enExample) |
| AU (1) | AU571273B2 (enExample) |
| CA (1) | CA1244430A (enExample) |
| DE (1) | DE3482322D1 (enExample) |
| DK (1) | DK162639C (enExample) |
| ES (1) | ES8507513A1 (enExample) |
| NO (1) | NO170682C (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0674251B2 (ja) * | 1986-02-07 | 1994-09-21 | 全薬工業株式▲会▼社 | ビス−ジオキソピペラジン誘導体 |
| ES2082979T3 (es) * | 1990-07-04 | 1996-04-01 | Zenyaku Kogyo Kk | Derivados de bis-dioxopiperazina hidrosolubles con propiedades antitumorales. |
| JP5732453B2 (ja) * | 2009-06-25 | 2015-06-10 | アルカーメス ファーマ アイルランド リミテッド | Ｎｈ酸性化合物のプロドラッグ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL273691A (enExample) * | 1961-01-19 | 1900-01-01 | ||
| GB1234935A (en) * | 1967-07-03 | 1971-06-09 | Nat Res Dev | Piperazine derivatives |
| GB1236947A (en) * | 1968-08-15 | 1971-06-23 | Ici Ltd | Process for the preparation of piperazine derivatives |
| DE2511891A1 (de) * | 1975-03-19 | 1976-10-07 | Gruenenthal Chemie | Neue derivate des 2,6-dioxopiperazins, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel sowie verfahren zu deren herstellung |
| CH635828A5 (de) * | 1978-08-30 | 1983-04-29 | Ciba Geigy Ag | N-substituierte imide und bisimide. |
| US4404381A (en) * | 1981-06-19 | 1983-09-13 | The Dow Chemical Company | Novel 3,5-diketo-piperazinyl compounds containing epoxide substituted imides |
| US4536564A (en) * | 1983-12-09 | 1985-08-20 | The Dow Chemical Company | Polyamide from bis-carboxy containing 3,5,3',5'-tetraoxo-1,2-dipiperazine compound and diamine |
-
1983
- 1983-10-31 JP JP58204448A patent/JPS6097963A/ja active Granted
-
1984
- 1984-10-16 DK DK493384A patent/DK162639C/da not_active IP Right Cessation
- 1984-10-17 AU AU34416/84A patent/AU571273B2/en not_active Ceased
- 1984-10-19 NO NO844183A patent/NO170682C/no not_active IP Right Cessation
- 1984-10-23 EP EP84112763A patent/EP0140327B1/en not_active Expired - Lifetime
- 1984-10-23 DE DE8484112763T patent/DE3482322D1/de not_active Expired - Fee Related
- 1984-10-25 US US06/664,700 patent/US4650799A/en not_active Expired - Lifetime
- 1984-10-30 ES ES537206A patent/ES8507513A1/es not_active Expired
- 1984-10-30 CA CA000466567A patent/CA1244430A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3441684A (en) | 1985-05-09 |
| EP0140327B1 (en) | 1990-05-23 |
| DK493384A (da) | 1985-05-01 |
| NO170682B (no) | 1992-08-10 |
| US4650799A (en) | 1987-03-17 |
| ES537206A0 (es) | 1985-09-01 |
| EP0140327A3 (en) | 1986-07-23 |
| JPS6334153B2 (enExample) | 1988-07-08 |
| NO170682C (no) | 1992-11-18 |
| CA1244430A (en) | 1988-11-08 |
| DK162639B (da) | 1991-11-25 |
| DE3482322D1 (de) | 1990-06-28 |
| AU571273B2 (en) | 1988-04-14 |
| JPS6097963A (ja) | 1985-05-31 |
| DK162639C (da) | 1992-04-13 |
| DK493384D0 (da) | 1984-10-16 |
| EP0140327A2 (en) | 1985-05-08 |
| NO844183L (no) | 1985-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20041102 |