ES8507476A1 - Un procedimiento para la preparacion de nuevos benzonitrilos - Google Patents

Un procedimiento para la preparacion de nuevos benzonitrilos

Info

Publication number
ES8507476A1
ES8507476A1 ES529879A ES529879A ES8507476A1 ES 8507476 A1 ES8507476 A1 ES 8507476A1 ES 529879 A ES529879 A ES 529879A ES 529879 A ES529879 A ES 529879A ES 8507476 A1 ES8507476 A1 ES 8507476A1
Authority
ES
Spain
Prior art keywords
hydrogen
image
enterotoxin
amidine derivatives
induced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529879A
Other languages
English (en)
Other versions
ES529879A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES529879A0 publication Critical patent/ES529879A0/es
Publication of ES8507476A1 publication Critical patent/ES8507476A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE BENZONITRILOS, DE FORMULA GENERAL (I), EN LA QUE R5 ES HIDROGENO, HIDROXI, ALCOXI, ARILOXI O HETEROARILOXI, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R5 TIENE EL SIGNIFICADO YA MENCIONADO; E Y ES HALOGENO, CON UN REACTIVO DE CIANURO APROPIADO Y, OPCIONALMENTE, SE PUEDE CONVERTIR EL COMPUESTO DE FORMULA (I) EN OTRO COMPUESTO DE FORMULA (I).DE APLICACION EN EL TRATAMIENTO DE DIARREAS INDUCIDAS POR ENTEROTOXINAS EN PERSONAS Y DE DIARREAS BLANCAS EN ANIMALES.
ES529879A 1982-06-16 1984-02-20 Un procedimiento para la preparacion de nuevos benzonitrilos Expired ES8507476A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8217452 1982-06-16

Publications (2)

Publication Number Publication Date
ES529879A0 ES529879A0 (es) 1985-09-01
ES8507476A1 true ES8507476A1 (es) 1985-09-01

Family

ID=10531083

Family Applications (2)

Application Number Title Priority Date Filing Date
ES523305A Granted ES523305A0 (es) 1982-06-16 1983-06-15 Un procedimiento para la preparacion de nuevos derivados de amidina.
ES529879A Expired ES8507476A1 (es) 1982-06-16 1984-02-20 Un procedimiento para la preparacion de nuevos benzonitrilos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES523305A Granted ES523305A0 (es) 1982-06-16 1983-06-15 Un procedimiento para la preparacion de nuevos derivados de amidina.

Country Status (7)

Country Link
US (2) US4539319A (es)
EP (1) EP0097463A3 (es)
JP (1) JPS597151A (es)
AU (1) AU1575483A (es)
DK (1) DK273183A (es)
ES (2) ES523305A0 (es)
ZA (1) ZA834347B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508588D0 (en) * 1985-04-02 1985-05-09 Akzo Nv Indene & napthalene derivatives
PL180081B1 (pl) * 1993-08-12 2000-12-29 Astra Ab Nowe pochodne amidyny i sposób ich wytwarzania PL PL PL PL PL PL PL
US5869458A (en) * 1994-10-14 1999-02-09 Waite; Christopher S. Frozen rehydration formulation and delivery system therefor
WO1996041185A1 (en) * 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Methods and compositions for binding endotoxins
US6572898B2 (en) 1999-05-21 2003-06-03 Pts Labs Llc Electrolyte gels for maintaining hydration and rehydration
US20110245171A1 (en) * 2004-09-30 2011-10-06 Hardin James A Rehydration compositions comprising epidermal growth factor (egf)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2491473A (en) * 1948-11-16 1949-12-20 Burroughs Wellcome Co N-dialkyl alkoxynaphthamidines
US2575991A (en) * 1949-03-24 1951-11-20 Burroughs Wellcome Co Cinnamamidine derivatives
US3259646A (en) * 1963-05-13 1966-07-05 Schering Corp Process for the preparation of p-hydroxybenzonitrile
EP0047817A3 (de) * 1980-08-14 1982-05-26 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Hydrierte Naphthaline, deren Herstellung und Verwendung sowie derartige Naphthaline enthaltende Gemische

Also Published As

Publication number Publication date
US4539319A (en) 1985-09-03
DK273183D0 (da) 1983-06-14
EP0097463A2 (en) 1984-01-04
ZA834347B (en) 1984-04-25
DK273183A (da) 1983-12-17
US4594195A (en) 1986-06-10
JPS597151A (ja) 1984-01-14
ES8500220A1 (es) 1984-10-01
ES523305A0 (es) 1984-10-01
ES529879A0 (es) 1985-09-01
EP0097463A3 (en) 1985-05-15
AU1575483A (en) 1983-12-22

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