ES8506646A1 - Un procedimiento para preparar derivados de pirimidona - Google Patents

Un procedimiento para preparar derivados de pirimidona

Info

Publication number
ES8506646A1
ES8506646A1 ES528304A ES528304A ES8506646A1 ES 8506646 A1 ES8506646 A1 ES 8506646A1 ES 528304 A ES528304 A ES 528304A ES 528304 A ES528304 A ES 528304A ES 8506646 A1 ES8506646 A1 ES 8506646A1
Authority
ES
Spain
Prior art keywords
substitutes
histamine
solvent
antagonists
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528304A
Other languages
English (en)
Other versions
ES528304A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES528304A0 publication Critical patent/ES528304A0/es
Publication of ES8506646A1 publication Critical patent/ES8506646A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE COMPUESTOS DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDOS FARMACOLOGICAMENTE ACEPTABLE, DONDE R1 ES 2- O 3-PIRIDILO CON O SIN SUSTITUYENTES; R2 ES FENILO CON O SIN SUSTITUYENTES; Y A SE SITUA ENTRE 2 Y 4.SE OBTIENEN POR REACCION DE UN COMPUESTO R1X1 DONDE X1 ES HALOGENO O UN GRUPO -NH(CH2)ANH2 CON UN COMPUESTO DE FORMULA (II), A TEMPERATURA ENTRE 120JC Y 140JC Y EN AUSENCIA DE DISOLVENTE, O CON DISOLVENTE TAL COMO PIRIDINA, PICOLINA, ETANOL U OTROS, A MAYOR TEMPERATURA.DE APLICACION PARA EL TRATAMIENTO DE ENFERMEDADES COMO EL ASMA BRONQUIAL, RINITIS, LA FIEBRE DEL HENO Y EL ECZEMA ALERGICO.
ES528304A 1982-12-23 1983-12-22 Un procedimiento para preparar derivados de pirimidona Expired ES8506646A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8236636 1982-12-23

Publications (2)

Publication Number Publication Date
ES528304A0 ES528304A0 (es) 1985-08-01
ES8506646A1 true ES8506646A1 (es) 1985-08-01

Family

ID=10535200

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528304A Expired ES8506646A1 (es) 1982-12-23 1983-12-22 Un procedimiento para preparar derivados de pirimidona

Country Status (10)

Country Link
US (2) US4548940A (es)
EP (1) EP0112707B1 (es)
JP (1) JPS59134790A (es)
AU (1) AU2274583A (es)
DE (1) DE3374313D1 (es)
DK (1) DK590383A (es)
ES (1) ES8506646A1 (es)
GR (1) GR79741B (es)
PT (1) PT77860B (es)
ZA (1) ZA839536B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1286297C (en) * 1985-06-13 1991-07-16 George S. Sach Pyridine derivatives
GB8601816D0 (en) * 1986-01-25 1986-02-26 Smith Kline French Lab Pyridine derivatives
US5030645A (en) * 1990-10-15 1991-07-09 Merck & Co., Inc. Method of treating asthma using (S)-α-fluoromethyl-histidine and esters thereof
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9412573D0 (en) * 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412571D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US6417185B1 (en) 1998-06-19 2002-07-09 Chiron Corporation Inhibitors of glycogen synthase kinase 3
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
JP4291135B2 (ja) * 2001-05-29 2009-07-08 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Ｃｄｋ阻害性ピリミジン、それらの製造および薬剤としての使用
CN106946769B (zh) * 2017-04-16 2019-04-02 内蒙古佳瑞米精细化工有限公司 一种2-氟-5-三氟甲基吡啶的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3535328A (en) * 1967-09-01 1970-10-20 Exxon Research Engineering Co Certain substituted aminothioethoxy pyridines
US3553292A (en) * 1968-12-10 1971-01-05 Grace W R & Co Product and a method of improving the shelf life of uncured polyesters
US4218452A (en) * 1975-10-02 1980-08-19 Smith Kline & French Laboratories Limited Substituted 4-pyrimidone compounds, compositions and methods of use
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
US4405790A (en) * 1982-04-08 1983-09-20 Reilly Tar & Chemical Corp. Process for preparing 2-alkylamino- and 2-amino-5-alkylpyridines
DE3375574D1 (en) * 1982-12-23 1988-03-10 Smith Kline French Lab Pyridine derivatives
PT77855B (en) * 1982-12-23 1986-04-16 Smith Kline French Lab Pyridine derivatives

Also Published As

Publication number Publication date
EP0112707B1 (en) 1987-11-04
JPS59134790A (ja) 1984-08-02
DE3374313D1 (de) 1987-12-10
US4548940A (en) 1985-10-22
ES528304A0 (es) 1985-08-01
PT77860B (en) 1986-04-16
DK590383D0 (da) 1983-12-21
US4652650A (en) 1987-03-24
EP0112707A3 (en) 1985-09-25
ZA839536B (en) 1985-02-27
PT77860A (en) 1984-01-01
AU2274583A (en) 1984-06-28
EP0112707A2 (en) 1984-07-04
GR79741B (es) 1984-10-31
DK590383A (da) 1984-06-24

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