ES8506281A1 - Procedimiento de preparacion de precursores de 3-quinolein-carboxamidas sustituidas en la posicion 2 - Google Patents

Procedimiento de preparacion de precursores de 3-quinolein-carboxamidas sustituidas en la posicion 2

Info

Publication number
ES8506281A1
ES8506281A1 ES536903A ES536903A ES8506281A1 ES 8506281 A1 ES8506281 A1 ES 8506281A1 ES 536903 A ES536903 A ES 536903A ES 536903 A ES536903 A ES 536903A ES 8506281 A1 ES8506281 A1 ES 8506281A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
group
halogen
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536903A
Other languages
English (en)
Other versions
ES536903A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES8506281A1 publication Critical patent/ES8506281A1/es
Publication of ES536903A0 publication Critical patent/ES536903A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE PRECURSORES DE 3-QUINOLEIN-CARBOXAMIDAS SUSTITUIDAS EN LA POSICION 2.CONSISTE EN SOMETER, EN PRESENCIA DE UNA BASE, UN COMPUESTO DE FORMULA (II) A LA ACCION DE UN COMPUESTO DE FORMULA (III) PARA OBTENER UN COMPUESTO DE FORMULA (IV) QUE SE SOMETE A UNA DESCARBOALCOXILACION EN UN MEDIO ACIDO PARA OBTENER PRECURSORES DE 3-QUINOLEIN-CARBOXAMIDAS SUSTITUIDAS EN LA POSICION 2 DE FORMULA (I), EN LA QUE X EN LA POSICION 5, 6, 7 U 8 REPRESENTA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO Y OTROS; R1 ES UN ATOMO DE HIDROGENO O UN RADICAL ALQUILO CON C 1 A 4; R2 ES UN ATOMO DE HIDROGENO O UN RADICAL TIAZOLILO; R3 ES UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO Y OTROS; R4 ES UN ATOMO DE HIDROGENO O UN ATOMO DE HALOGENO; Y R5 ES UN ATOMO DE HALOGENO. LA REACCION SE EFECTUA EN EL SENO DE TETRAHIDROFURANO.
ES536903A 1983-10-20 1984-10-19 Procedimiento de preparacion de precursores de 3-quinolein-carboxamidas sustituidas en la posicion 2 Granted ES536903A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8316699A FR2553769B1 (fr) 1983-10-20 1983-10-20 Nouveau procede de preparation de derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2

Publications (2)

Publication Number Publication Date
ES8506281A1 true ES8506281A1 (es) 1985-07-01
ES536903A0 ES536903A0 (es) 1985-07-01

Family

ID=9293338

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536903A Granted ES536903A0 (es) 1983-10-20 1984-10-19 Procedimiento de preparacion de precursores de 3-quinolein-carboxamidas sustituidas en la posicion 2

Country Status (11)

Country Link
US (1) US4687857A (es)
EP (1) EP0141713B1 (es)
JP (1) JPS60109552A (es)
AT (1) ATE53208T1 (es)
CA (1) CA1228074A (es)
DE (1) DE3482386D1 (es)
ES (1) ES536903A0 (es)
FI (1) FI93726C (es)
FR (1) FR2553769B1 (es)
HU (1) HU190879B (es)
PT (1) PT79383B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100997A (en) * 1990-05-29 1992-03-31 Olin Corporation Preparation of elastomers using high molecular weight polyols or polyamines, said polyols prepared using a double metal cyanide complex catalyst

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798227A (en) * 1966-06-15 1974-03-19 Sterling Drug Inc Process of cyclizing alkylidene substituted aminomethylenemalonates
US4154756A (en) * 1977-12-15 1979-05-15 American Cyanamid Company 2-Substituted-4'-(monoalkylamino)-acetophenones
FR2482596A1 (fr) * 1980-05-19 1981-11-20 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament
FR2530633A1 (fr) * 1982-06-03 1984-01-27 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant

Also Published As

Publication number Publication date
US4687857A (en) 1987-08-18
PT79383B (fr) 1986-11-14
FI93726B (fi) 1995-02-15
JPS60109552A (ja) 1985-06-15
CA1228074A (fr) 1987-10-13
FR2553769A1 (fr) 1985-04-26
PT79383A (fr) 1984-11-01
FR2553769B1 (fr) 1986-03-14
FI844131A0 (fi) 1984-10-19
FI844131L (fi) 1985-04-21
DE3482386D1 (de) 1990-07-05
ES536903A0 (es) 1985-07-01
EP0141713B1 (fr) 1990-05-30
JPH0475907B2 (es) 1992-12-02
HUT37921A (en) 1986-03-28
ATE53208T1 (de) 1990-06-15
FI93726C (fi) 1995-05-26
HU190879B (en) 1986-11-28
EP0141713A1 (fr) 1985-05-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102