ES8506031A1 - Un procedimiento para la preparacion de derivados de ergolina - Google Patents
Un procedimiento para la preparacion de derivados de ergolinaInfo
- Publication number
- ES8506031A1 ES8506031A1 ES531906A ES531906A ES8506031A1 ES 8506031 A1 ES8506031 A1 ES 8506031A1 ES 531906 A ES531906 A ES 531906A ES 531906 A ES531906 A ES 531906A ES 8506031 A1 ES8506031 A1 ES 8506031A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- processes
- containing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ERGOLINA.CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (XFCFNFR5), EN UN DISOLVENTE COMO AGUA, ETANOL, ACIDO ACETICO Y A UNA TEMPERATURA ENTRE 50J Y 100JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO; R1, H O METILO; R2, H, HAL, METILO U OTROS; R3 H O METOXI; R4 GRUPO HIDROCARBILO DE C 1 A 4; R5 H O UN GRUPO HIDROCARBILO DE C 1 A 4; R6, H O ALQUILO DE C 1 A 4; R7, R8 Y R9, H; A, -CHR6, CH2-CHR6 Y OTROS; B, CIANO (ALCOXI C 2 A 5) CARBONILO Y OTROS; X, O, S O IMINO Y N 0, 1 O 2.SE UTILIZAN COMO ANTIPROLACTINICOS Y ANTIHIPERTENSIVOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838311679A GB8311679D0 (en) | 1983-04-28 | 1983-04-28 | Ergoline derivatives |
GB838314816A GB8314816D0 (en) | 1983-05-27 | 1983-05-27 | Ergoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8506031A1 true ES8506031A1 (es) | 1985-06-01 |
ES531906A0 ES531906A0 (es) | 1985-06-01 |
Family
ID=26285978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES531906A Granted ES531906A0 (es) | 1983-04-28 | 1984-04-25 | Un procedimiento para la preparacion de derivados de ergolina |
Country Status (18)
Country | Link |
---|---|
US (1) | US4690929A (es) |
EP (1) | EP0126968B1 (es) |
KR (1) | KR900008696B1 (es) |
AU (1) | AU556968B2 (es) |
CA (1) | CA1205801A (es) |
DE (1) | DE3475709D1 (es) |
DK (1) | DK162996C (es) |
ES (1) | ES531906A0 (es) |
FI (1) | FI81349C (es) |
GR (1) | GR79575B (es) |
HU (1) | HU198713B (es) |
IE (1) | IE57240B1 (es) |
IL (1) | IL71633A (es) |
NO (1) | NO161562C (es) |
PH (1) | PH21123A (es) |
PT (1) | PT78496B (es) |
SU (1) | SU1327788A3 (es) |
YU (1) | YU43357B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8714767D0 (en) * | 1987-06-24 | 1987-07-29 | Erba Farmitalia | Egoline derivatives |
HU196399B (en) * | 1983-02-16 | 1988-11-28 | Sandoz Ag | Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds |
GB8501078D0 (en) * | 1985-01-16 | 1985-02-20 | Erba Farmitalia | Piperazin-1-yl-ergo-line derivatives |
GB2173189B (en) * | 1985-02-21 | 1988-04-27 | Maruko Pharmaceutical Co | Ergoline derivatives and salts thereof and pharmaceutical compositions thereof |
GB8515528D0 (en) * | 1985-06-19 | 1985-07-24 | Erba Farmitalia | Ergoline derivatives |
US4801712A (en) * | 1985-06-24 | 1989-01-31 | Eli Lilly And Company | 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity |
DE3528576A1 (de) * | 1985-08-06 | 1987-02-19 | Schering Ag | Verfahren zur herstellung von ergolin-thioharnstoffen |
DE3535929A1 (de) * | 1985-10-04 | 1987-04-09 | Schering Ag | 1,2-disubstituierte ergolinderivate |
GB8617907D0 (en) * | 1986-07-22 | 1986-08-28 | Erba Farmitalia | Tetracyclic indole derivatives |
GB8702364D0 (en) * | 1987-02-03 | 1987-03-11 | Erba Farmitalia | Ergolinyl heterocycles |
DK338789A (da) * | 1988-07-15 | 1990-01-16 | Schering Ag | 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf |
WO1991011447A1 (en) * | 1990-01-25 | 1991-08-08 | Farmitalia Carlo Erba S.R.L. | Process for preparing ergoline derivatives |
GB9006772D0 (en) * | 1990-03-27 | 1990-05-23 | Erba Carlo Spa | 4-piperidinyl-ergoline derivatives |
DE69330601T2 (de) * | 1992-12-24 | 2002-07-04 | Pharmacia & Upjohn S.P.A., Mailand/Milano | Serotoninergische ergolin derivate |
WO2002100888A1 (en) | 2001-06-08 | 2002-12-19 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Somatostatin-dopamine chimeric analogs |
TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素-多巴胺嵌合體類似物 |
RU2015120570A (ru) | 2012-11-01 | 2016-12-20 | Ипсен Фарма С.А.С. | Аналоги соматостатина и их димеры |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL283102A (es) * | 1961-09-11 | |||
DK140596B (da) * | 1971-05-19 | 1979-10-08 | Sandoz Ag | Analogifremgangsmåde til fremstilling af 8beta-(ureidomethyl)-ergolenderivater. |
US3996228A (en) * | 1973-12-21 | 1976-12-07 | Societa' Farmaceutici Italia S.P.A. | Pyrimidinoaminoethyl ergoline derivatives |
NL7416120A (nl) * | 1973-12-21 | 1975-06-24 | Farmaceutici Italia | Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten. |
DE2456930A1 (de) * | 1974-12-02 | 1976-08-12 | Tesch Kg E | Elektronisches zeitspeicherrelais |
CH615181A5 (en) * | 1975-05-21 | 1980-01-15 | Sandoz Ag | Process for the preparation of novel ergolene derivatives |
GB2056437A (en) * | 1979-08-07 | 1981-03-18 | Erba Farmitalia | Secoergoline derivatives |
DE3001752A1 (de) * | 1980-01-16 | 1981-07-30 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen |
DD154897A1 (de) * | 1980-12-02 | 1982-04-28 | Seifert Karlheinz Dipl Chem Dr | Verfahren zur herstellung von 8-substituierten ergolinen |
DE3101535A1 (de) * | 1981-01-14 | 1982-08-12 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
GB2112382B (en) * | 1981-11-06 | 1985-03-06 | Erba Farmitalia | Ergoline derivatives |
-
1984
- 1984-04-23 PH PH30590A patent/PH21123A/en unknown
- 1984-04-24 EP EP84104568A patent/EP0126968B1/en not_active Expired
- 1984-04-24 DE DE8484104568T patent/DE3475709D1/de not_active Expired
- 1984-04-24 CA CA000452664A patent/CA1205801A/en not_active Expired
- 1984-04-24 SU SU843728545A patent/SU1327788A3/ru active
- 1984-04-25 IL IL71633A patent/IL71633A/xx not_active IP Right Cessation
- 1984-04-25 ES ES531906A patent/ES531906A0/es active Granted
- 1984-04-25 FI FI841631A patent/FI81349C/fi not_active IP Right Cessation
- 1984-04-26 US US06/604,041 patent/US4690929A/en not_active Expired - Fee Related
- 1984-04-26 YU YU742/84A patent/YU43357B/xx unknown
- 1984-04-26 NO NO841657A patent/NO161562C/no unknown
- 1984-04-26 GR GR74511A patent/GR79575B/el unknown
- 1984-04-26 IE IE1018/84A patent/IE57240B1/en not_active IP Right Cessation
- 1984-04-26 PT PT78496A patent/PT78496B/pt not_active IP Right Cessation
- 1984-04-27 KR KR1019840002271A patent/KR900008696B1/ko not_active IP Right Cessation
- 1984-04-27 DK DK212784A patent/DK162996C/da not_active IP Right Cessation
- 1984-04-27 HU HU841656A patent/HU198713B/hu not_active IP Right Cessation
- 1984-04-27 AU AU27421/84A patent/AU556968B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
FI81349C (fi) | 1990-10-10 |
HU198713B (en) | 1989-11-28 |
SU1327788A3 (ru) | 1987-07-30 |
DK162996C (da) | 1992-06-01 |
ES531906A0 (es) | 1985-06-01 |
NO161562B (no) | 1989-05-22 |
FI841631A (es) | 1984-10-29 |
EP0126968B1 (en) | 1988-12-21 |
NO841657L (no) | 1984-10-29 |
CA1205801A (en) | 1986-06-10 |
US4690929A (en) | 1987-09-01 |
HUT34024A (en) | 1985-01-28 |
KR840008353A (ko) | 1984-12-14 |
PT78496B (en) | 1986-07-22 |
IL71633A0 (en) | 1984-07-31 |
EP0126968A1 (en) | 1984-12-05 |
PH21123A (en) | 1987-07-27 |
GR79575B (es) | 1984-10-30 |
YU43357B (en) | 1989-06-30 |
DK162996B (da) | 1992-01-06 |
IE57240B1 (en) | 1992-06-17 |
DK212784A (da) | 1984-10-29 |
FI81349B (fi) | 1990-06-29 |
IL71633A (en) | 1987-12-20 |
FI841631A0 (es) | 1984-04-25 |
KR900008696B1 (ko) | 1990-11-27 |
AU556968B2 (en) | 1986-11-27 |
PT78496A (en) | 1984-05-01 |
DE3475709D1 (en) | 1989-01-26 |
AU2742184A (en) | 1984-11-01 |
DK212784D0 (da) | 1984-04-27 |
YU74284A (en) | 1986-10-31 |
NO161562C (no) | 1989-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980202 |