ES8505721A1 - Un procedimiento para la preparacion de inhibidores enzimaticos convatidores de la angiotensina. - Google Patents
Un procedimiento para la preparacion de inhibidores enzimaticos convatidores de la angiotensina.Info
- Publication number
- ES8505721A1 ES8505721A1 ES524874A ES524874A ES8505721A1 ES 8505721 A1 ES8505721 A1 ES 8505721A1 ES 524874 A ES524874 A ES 524874A ES 524874 A ES524874 A ES 524874A ES 8505721 A1 ES8505721 A1 ES 8505721A1
- Authority
- ES
- Spain
- Prior art keywords
- enzyme inhibitors
- alkyl
- formula
- phthalidyl
- halophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE INHIBIDORES ENZIMATICOS CONVERTIDORES DE LA ANGIOTENSINA.CONSISTE EN CULTIVAR STREPTOMYCES CHROMOFUSCUS NRRL 15098, EN UN MEDIO DE CULTIVO NUTRITIVO QUE CONTIENE FUENTES ASIMILABLES DE C, N, SALES INORGANICAS, PROLINA Y LISINA, Y EN CONDICIONES DE FERMENTACION AEROBIA SUMERGIDA, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R Y R1 IGUALES O DIFERENTES, H, ALQUILO DE C 1 A 6, INDAN-5-ILO Y OTROS; Y N, 1 O 2.SE UTILIZAN COMO INHIBIDORES ENZIMATICOS CONVERTIDORES DE LA ANGIOTENSINA A-58365.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/409,764 US4404282A (en) | 1982-08-19 | 1982-08-19 | Process for enzyme inhibitor |
US06/409,763 US4508901A (en) | 1982-08-19 | 1982-08-19 | Quiuolizine and indolizine enzyme inhibitors |
US06/409,765 US4404281A (en) | 1982-08-19 | 1982-08-19 | Process for enzyme inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8505721A1 true ES8505721A1 (es) | 1985-06-01 |
ES524874A0 ES524874A0 (es) | 1985-06-01 |
Family
ID=27410818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524874A Granted ES524874A0 (es) | 1982-08-19 | 1983-08-11 | Un procedimiento para la preparacion de inhibidores enzimaticos convatidores de la angiotensina. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0103403B1 (es) |
KR (1) | KR860001215B1 (es) |
AU (1) | AU560417B2 (es) |
DD (1) | DD218389A5 (es) |
DE (1) | DE3381244D1 (es) |
DK (1) | DK377883A (es) |
ES (1) | ES524874A0 (es) |
FI (1) | FI832960A (es) |
GB (1) | GB2126217B (es) |
GR (1) | GR78665B (es) |
IL (1) | IL69474A (es) |
NZ (1) | NZ205245A (es) |
PL (1) | PL243461A1 (es) |
PT (1) | PT77190B (es) |
SU (1) | SU1403991A3 (es) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4316906A (en) * | 1978-08-11 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of substituted prolines |
US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
-
1983
- 1983-08-11 GR GR72200A patent/GR78665B/el unknown
- 1983-08-11 ES ES524874A patent/ES524874A0/es active Granted
- 1983-08-11 DE DE8383304636T patent/DE3381244D1/de not_active Expired - Lifetime
- 1983-08-11 GB GB08321679A patent/GB2126217B/en not_active Expired
- 1983-08-11 EP EP83304636A patent/EP0103403B1/en not_active Expired - Lifetime
- 1983-08-11 AU AU17904/83A patent/AU560417B2/en not_active Ceased
- 1983-08-12 PT PT77190A patent/PT77190B/pt unknown
- 1983-08-12 IL IL69474A patent/IL69474A/xx unknown
- 1983-08-12 NZ NZ205245A patent/NZ205245A/en unknown
- 1983-08-15 DD DD83253962A patent/DD218389A5/de unknown
- 1983-08-15 SU SU833635270A patent/SU1403991A3/ru active
- 1983-08-18 FI FI832960A patent/FI832960A/fi not_active Application Discontinuation
- 1983-08-18 KR KR1019830003852A patent/KR860001215B1/ko active Pre-grant Review Request
- 1983-08-18 DK DK377883A patent/DK377883A/da not_active Application Discontinuation
- 1983-08-18 PL PL24346183A patent/PL243461A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PL243461A1 (en) | 1985-01-02 |
DK377883D0 (da) | 1983-08-18 |
NZ205245A (en) | 1987-01-23 |
SU1403991A3 (ru) | 1988-06-15 |
DE3381244D1 (de) | 1990-04-05 |
KR840005743A (ko) | 1984-11-15 |
FI832960A (fi) | 1984-02-20 |
IL69474A (en) | 1986-11-30 |
DK377883A (da) | 1984-02-20 |
PT77190A (en) | 1983-09-01 |
GR78665B (es) | 1984-09-27 |
EP0103403A2 (en) | 1984-03-21 |
DD218389A5 (de) | 1985-02-06 |
GB2126217A (en) | 1984-03-21 |
GB2126217B (en) | 1986-04-03 |
AU560417B2 (en) | 1987-04-09 |
PT77190B (en) | 1986-03-20 |
ES524874A0 (es) | 1985-06-01 |
EP0103403B1 (en) | 1990-02-28 |
FI832960A0 (fi) | 1983-08-18 |
AU1790483A (en) | 1984-02-23 |
GB8321679D0 (en) | 1983-09-14 |
IL69474A0 (en) | 1983-11-30 |
EP0103403A3 (en) | 1986-07-02 |
KR860001215B1 (ko) | 1986-08-27 |
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