ES8505647A1 - Procedimiento para preparar un derivado de insulina - Google Patents

Procedimiento para preparar un derivado de insulina

Info

Publication number
ES8505647A1
ES8505647A1 ES536115A ES536115A ES8505647A1 ES 8505647 A1 ES8505647 A1 ES 8505647A1 ES 536115 A ES536115 A ES 536115A ES 536115 A ES536115 A ES 536115A ES 8505647 A1 ES8505647 A1 ES 8505647A1
Authority
ES
Spain
Prior art keywords
des
group
human insulin
phe
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536115A
Other languages
English (en)
Other versions
ES536115A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES536115A0 publication Critical patent/ES536115A0/es
Publication of ES8505647A1 publication Critical patent/ES8505647A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE INSULINA.COMPRENDE: A) HACER REACCIONAR UNA DES-B30-INSULINA DE FORMULA (I) DONDE R ES H Y EL C-TERMINO R-R ES OH, CON UN COMPUESTO DE FORMULA (II), EN PRESENCIA DE TRIPSINA; Y B) SEPARAR LOS GRUPOS PROTECTORES PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE COMPATIBLES. SIENDO: R, H; R EL RADICAL DE UN L-AMINOACIDO NEUTRO, GENETICAMENTE CODIFICABLE CUYO GRUPO OH SE PRESENTA EN ESTADO LIBRE O PROTEGIDO POR UN GRUPO FISIOLOGICAMENTE COMPATIBLE; Y R PROTEGIDO POR UN GRUPO SN NEUTRO, QUE BLOQUEA EL GRUPO CARBOXI FISIOLOGICAMENTE COMPATIBLE.
ES536115A 1983-09-23 1984-09-21 Procedimiento para preparar un derivado de insulina Expired ES8505647A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833334407 DE3334407A1 (de) 1983-09-23 1983-09-23 In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus

Publications (2)

Publication Number Publication Date
ES536115A0 ES536115A0 (es) 1985-06-01
ES8505647A1 true ES8505647A1 (es) 1985-06-01

Family

ID=6209839

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536115A Expired ES8505647A1 (es) 1983-09-23 1984-09-21 Procedimiento para preparar un derivado de insulina

Country Status (18)

Country Link
EP (1) EP0137361B1 (es)
JP (1) JPS6094999A (es)
KR (1) KR850002287A (es)
AT (1) ATE52791T1 (es)
AU (1) AU573624B2 (es)
CA (1) CA1247545A (es)
DE (2) DE3334407A1 (es)
DK (1) DK172632B1 (es)
ES (1) ES8505647A1 (es)
FI (1) FI843695L (es)
GR (1) GR80441B (es)
HU (1) HUT36843A (es)
IE (1) IE57669B1 (es)
IL (1) IL73021A (es)
NO (1) NO843799L (es)
NZ (1) NZ209620A (es)
PT (1) PT79249A (es)
ZA (1) ZA847440B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2069502A (en) * 1936-04-21 1937-02-02 American Floor Surfacing Mach Sanderplane
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2433883C2 (de) * 1973-07-20 1986-03-27 Research Corp., New York, N.Y. Verwendung von physiologisch aktiven Polypeptiden
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
JPS5767548A (en) * 1980-10-14 1982-04-24 Shionogi & Co Ltd Insulin analog and its preparation
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung

Also Published As

Publication number Publication date
IE57669B1 (en) 1993-02-24
DE3482265D1 (de) 1990-06-21
FI843695A0 (fi) 1984-09-20
IL73021A (en) 1989-09-10
DE3334407A1 (de) 1985-04-04
NO843799L (no) 1985-03-25
EP0137361A3 (en) 1987-05-06
CA1247545A (en) 1988-12-28
HUT36843A (en) 1985-10-28
AU573624B2 (en) 1988-06-16
PT79249A (de) 1984-10-01
KR850002287A (ko) 1985-05-10
GR80441B (en) 1985-01-21
JPS6094999A (ja) 1985-05-28
ATE52791T1 (de) 1990-06-15
DK172632B1 (da) 1999-03-22
EP0137361A2 (de) 1985-04-17
ZA847440B (en) 1985-05-29
ES536115A0 (es) 1985-06-01
IE842415L (en) 1985-03-23
FI843695L (fi) 1985-03-24
EP0137361B1 (de) 1990-05-16
AU3341984A (en) 1985-03-28
NZ209620A (en) 1988-03-30
IL73021A0 (en) 1984-12-31
DK453084D0 (da) 1984-09-21
DK453084A (da) 1985-03-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102