AU3341984A - Insulin derivatives modified in the b30 position - Google Patents
Insulin derivatives modified in the b30 positionInfo
- Publication number
- AU3341984A AU3341984A AU33419/84A AU3341984A AU3341984A AU 3341984 A AU3341984 A AU 3341984A AU 33419/84 A AU33419/84 A AU 33419/84A AU 3341984 A AU3341984 A AU 3341984A AU 3341984 A AU3341984 A AU 3341984A
- Authority
- AU
- Australia
- Prior art keywords
- des
- group
- human insulin
- phe
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 6
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 6
- 230000007935 neutral effect Effects 0.000 abstract 4
- 230000000903 blocking effect Effects 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 230000003111 delayed effect Effects 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000004026 insulin derivative Substances 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE A medicament having a delayed action for the treatment of diabetes mellitus, comprising at least one insulin derivative of the formula I see diagramm : EP0137361,P16,F1 in which R**1 denotes H or H-Phe R**30 represents the radical of a neutral, genetically codable L-aminoacid whose OH group, where present, can be free or protected by a physiologically acceptable group, and R**31 denotes a physiologically acceptable neutral group blocking the carboxyl group, with the exception of des-B30 human insulin Leu**B30 -NH2 and des-B30 human insulin Gly**B30 -NH2 and des-B30 human insulin Phe**B30 -NH2 and a pharmaceutically acceptable carrier. 1. Claims for the Contracting State : AT A process for the preparation of a medicament having a delayed action for the treatment of diabetes mellitus, which comprises bringing into a suitable dosage form at least one insulin derivative of the formula I see diagramm : EP0137361,P17,F1 in which R**1 denotes H or H-Phe R**30 represents the radical of a neutral, genetically codable L-aminoacid whose OH group, where present, can be free or protected by a physiologically acceptable group, and R**31 denotes a physiologically acceptable neutral group blocking the carboxyl group, with the exception of des-B30 human insulin Leu**B30 -NH2 and des-B30 human insulin Gly**B30 -NH, and des-B30 human insulin Phe**B30 -NH2 Phe**B30 -NH2 and a pharmaceutically acceptable carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3334407 | 1983-09-23 | ||
| DE19833334407 DE3334407A1 (en) | 1983-09-23 | 1983-09-23 | INSULINE DERIVATIVES MODIFIED IN POSITION B 30, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF THE DIABETES MELLITUS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3341984A true AU3341984A (en) | 1985-03-28 |
| AU573624B2 AU573624B2 (en) | 1988-06-16 |
Family
ID=6209839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU33419/84A Ceased AU573624B2 (en) | 1983-09-23 | 1984-09-21 | Insulin derivatives modified in the b30 position |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0137361B1 (en) |
| JP (1) | JPS6094999A (en) |
| KR (1) | KR850002287A (en) |
| AT (1) | ATE52791T1 (en) |
| AU (1) | AU573624B2 (en) |
| CA (1) | CA1247545A (en) |
| DE (2) | DE3334407A1 (en) |
| DK (1) | DK172632B1 (en) |
| ES (1) | ES8505647A1 (en) |
| FI (1) | FI843695L (en) |
| GR (1) | GR80441B (en) |
| HU (1) | HUT36843A (en) |
| IE (1) | IE57669B1 (en) |
| IL (1) | IL73021A (en) |
| NO (1) | NO843799L (en) |
| NZ (1) | NZ209620A (en) |
| PT (1) | PT79249A (en) |
| ZA (1) | ZA847440B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU568866B2 (en) * | 1983-08-03 | 1988-01-14 | Hoechst A.G. | Preparation of insulin derivatives |
| AU569097B2 (en) * | 1983-07-22 | 1988-01-21 | Hoechst A.G. | Insulin derivatives |
| AU577801B2 (en) * | 1983-09-17 | 1988-10-06 | Hoechst Aktiengesellschaft | Preparation of insulm derivatives, the b chain of which is lengthened c-terminally |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3827533A1 (en) * | 1988-08-13 | 1990-02-15 | Hoechst Ag | PHARMACEUTICAL PREPARATION FOR TREATING THE DIABETES MELLITUS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2069502A (en) * | 1936-04-21 | 1937-02-02 | American Floor Surfacing Mach | Sanderplane |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE2433883C2 (en) * | 1973-07-20 | 1986-03-27 | Research Corp., New York, N.Y. | Use of physiologically active polypeptides |
| DK147437A (en) * | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
| JPS5767548A (en) * | 1980-10-14 | 1982-04-24 | Shionogi & Co Ltd | Insulin analog and its preparation |
| DE3101382A1 (en) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "METHOD FOR PRODUCING HUMANISULIN OR ITS DERIVATIVES FROM PIG INSULIN OR ITS DERIVATIVES" |
| DE3333640A1 (en) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | METHOD FOR THE PRODUCTION OF INSULIN DERIVATIVES, THE B-CHAIN C-TERMINAL EXTENDED, NEW BASICALLY MODIFIED INSULIN DERIVATIVES, THE MEANS CONTAINING THEM AND THEIR USE |
-
1983
- 1983-09-23 DE DE19833334407 patent/DE3334407A1/en not_active Withdrawn
-
1984
- 1984-09-17 EP EP84111058A patent/EP0137361B1/en not_active Expired - Lifetime
- 1984-09-17 DE DE8484111058T patent/DE3482265D1/en not_active Expired - Fee Related
- 1984-09-17 AT AT84111058T patent/ATE52791T1/en not_active IP Right Cessation
- 1984-09-17 HU HU843491A patent/HUT36843A/en unknown
- 1984-09-20 FI FI843695A patent/FI843695L/en not_active Application Discontinuation
- 1984-09-21 KR KR1019840005799A patent/KR850002287A/en not_active Application Discontinuation
- 1984-09-21 CA CA000463810A patent/CA1247545A/en not_active Expired
- 1984-09-21 NO NO843799A patent/NO843799L/en unknown
- 1984-09-21 AU AU33419/84A patent/AU573624B2/en not_active Ceased
- 1984-09-21 GR GR80441A patent/GR80441B/en unknown
- 1984-09-21 DK DK198404530A patent/DK172632B1/en not_active IP Right Cessation
- 1984-09-21 ES ES536115A patent/ES8505647A1/en not_active Expired
- 1984-09-21 ZA ZA847440A patent/ZA847440B/en unknown
- 1984-09-21 JP JP59196962A patent/JPS6094999A/en active Pending
- 1984-09-21 IE IE2415/84A patent/IE57669B1/en not_active IP Right Cessation
- 1984-09-21 PT PT79249A patent/PT79249A/en unknown
- 1984-09-21 NZ NZ209620A patent/NZ209620A/en unknown
- 1984-09-21 IL IL73021A patent/IL73021A/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU569097B2 (en) * | 1983-07-22 | 1988-01-21 | Hoechst A.G. | Insulin derivatives |
| AU568866B2 (en) * | 1983-08-03 | 1988-01-14 | Hoechst A.G. | Preparation of insulin derivatives |
| AU577801B2 (en) * | 1983-09-17 | 1988-10-06 | Hoechst Aktiengesellschaft | Preparation of insulm derivatives, the b chain of which is lengthened c-terminally |
Also Published As
| Publication number | Publication date |
|---|---|
| IE57669B1 (en) | 1993-02-24 |
| DE3482265D1 (en) | 1990-06-21 |
| FI843695A0 (en) | 1984-09-20 |
| IL73021A (en) | 1989-09-10 |
| DE3334407A1 (en) | 1985-04-04 |
| NO843799L (en) | 1985-03-25 |
| EP0137361A3 (en) | 1987-05-06 |
| CA1247545A (en) | 1988-12-28 |
| HUT36843A (en) | 1985-10-28 |
| AU573624B2 (en) | 1988-06-16 |
| PT79249A (en) | 1984-10-01 |
| KR850002287A (en) | 1985-05-10 |
| GR80441B (en) | 1985-01-21 |
| JPS6094999A (en) | 1985-05-28 |
| ATE52791T1 (en) | 1990-06-15 |
| DK172632B1 (en) | 1999-03-22 |
| EP0137361A2 (en) | 1985-04-17 |
| ZA847440B (en) | 1985-05-29 |
| ES536115A0 (en) | 1985-06-01 |
| IE842415L (en) | 1985-03-23 |
| FI843695L (en) | 1985-03-24 |
| EP0137361B1 (en) | 1990-05-16 |
| NZ209620A (en) | 1988-03-30 |
| IL73021A0 (en) | 1984-12-31 |
| DK453084D0 (en) | 1984-09-21 |
| ES8505647A1 (en) | 1985-06-01 |
| DK453084A (en) | 1985-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |