ES8503006A1 - Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico - Google Patents

Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Info

Publication number
ES8503006A1
ES8503006A1 ES525614A ES525614A ES8503006A1 ES 8503006 A1 ES8503006 A1 ES 8503006A1 ES 525614 A ES525614 A ES 525614A ES 525614 A ES525614 A ES 525614A ES 8503006 A1 ES8503006 A1 ES 8503006A1
Authority
ES
Spain
Prior art keywords
group
carboxi
salt
lead
separate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525614A
Other languages
English (en)
Other versions
ES525614A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8503006A1 publication Critical patent/ES8503006A1/es
Publication of ES525614A0 publication Critical patent/ES525614A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ACIDO 6,BAB-METOXI-6,BBB-2-(2-METILFENOXICARBONIL)-2-(TIEN-3-IL)ACETAMIDOPENICILANICO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON METANOL EN PRESENCIA DE UN ION METALICO, COMO UNA SAL DE TELURO, PLOMO, PLATA, COBRE, BISMUTO, MERCURIO, PLOMO, CADMIO O TALIO, PARA OBTENER COMPUESTOS DE FORMULA (I). POSTERIORMENTE SE LLEVA A CABO: SEPARAR CUALQUIER SUSTITUYENTE DEL GRUPO AMIDO; SEPARAR EL GRUPO BLOQUEANTE DE CARBOXI RX; Y CONVERTIR EL PRODUCTO EN UNA SAL O EN UN ESTER HIDROLIZANTE IN VIVO DEL MISMO. RX SIGNIFICA UN GRUPO BLOQUEANTE DE CARBOXI Y R4 ES ALQUILO C 1 A 6, BENCILO O UN GRUPO ARILO. LA REACCION SE EFECTUA ENTRE C50JC Y B25JC DE TEMPERATURA.TIENE APLICACION FARMACEUTICA POR SU ACTIVIDAD CONTRA BACTERIAS GRAM-NEGATIVAS.
ES525614A 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico Granted ES525614A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8201751 1982-01-22

Publications (2)

Publication Number Publication Date
ES8503006A1 true ES8503006A1 (es) 1985-02-01
ES525614A0 ES525614A0 (es) 1985-02-01

Family

ID=10527789

Family Applications (4)

Application Number Title Priority Date Filing Date
ES519190A Granted ES519190A0 (es) 1982-01-22 1983-01-21 Un procedimiento para la preparacion de acido 6,-metoxi-6, -2-2-metilfenoxicarbonil-2-(tien-3-il) acetamido penicilanico.
ES525612A Expired ES8503004A1 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico
ES525614A Granted ES525614A0 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico
ES525613A Granted ES525613A0 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES519190A Granted ES519190A0 (es) 1982-01-22 1983-01-21 Un procedimiento para la preparacion de acido 6,-metoxi-6, -2-2-metilfenoxicarbonil-2-(tien-3-il) acetamido penicilanico.
ES525612A Expired ES8503004A1 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES525613A Granted ES525613A0 (es) 1982-01-22 1983-09-14 Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico

Country Status (18)

Country Link
US (1) US4455314A (es)
EP (1) EP0084948B1 (es)
JP (1) JPS58128389A (es)
KR (1) KR840003258A (es)
AT (1) ATE30592T1 (es)
AU (1) AU560185B2 (es)
CA (1) CA1217479A (es)
DE (1) DE3374316D1 (es)
DK (1) DK22983A (es)
ES (4) ES519190A0 (es)
FI (1) FI830192L (es)
GR (1) GR77867B (es)
IL (1) IL67672A0 (es)
NO (1) NO830183L (es)
NZ (1) NZ203065A (es)
PL (4) PL245812A1 (es)
PT (1) PT76128B (es)
ZA (1) ZA83377B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201922977A2 (tr) * 2019-12-31 2021-07-26 T C Erciyes Ueniversitesi Penisilin türevleri ve bunların sentezlenmesi için yöntem

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853849A (en) * 1969-05-29 1974-12-10 Beecham Group Ltd Alpha(aryloxycarbonyl)-and alpha(alkoxy-carbonyl)-aralkyl penicillins
HU168914B (es) * 1974-07-30 1976-08-28
GB1538051A (en) * 1975-01-17 1979-01-10 Beecham Group Ltd 6-methoxy-6-(alpha-carboxyacetamido)-penicillins
US4185014A (en) * 1976-06-26 1980-01-22 Beecham Group Limited Kentenimine intermediates for 6α-methoxy-α-carboxy penicillins
GB1577931A (en) * 1977-02-11 1980-10-29 Beecham Group Ltd 6-methoxy -6-(2-carboxy-2-(4-hydroxyphenyl) acetamido penicillins
ZA802445B (en) * 1979-05-15 1981-04-29 Beecham Group Ltd Process for the preparation of penicillin derivatives
GR70283B (es) * 1979-10-02 1982-09-03 Beecham Group Ltd

Also Published As

Publication number Publication date
EP0084948B1 (en) 1987-11-04
ZA83377B (en) 1983-10-26
ES8503005A1 (es) 1985-02-01
DK22983D0 (da) 1983-01-20
DE3374316D1 (en) 1987-12-10
IL67672A0 (en) 1983-05-15
PL245812A1 (en) 1984-09-24
PT76128B (en) 1987-02-05
FI830192A0 (fi) 1983-01-20
ES8403135A1 (es) 1984-03-01
PL245813A1 (en) 1984-09-24
NZ203065A (en) 1986-10-08
EP0084948A1 (en) 1983-08-03
ES519190A0 (es) 1984-03-01
PL240238A1 (en) 1984-06-18
AU560185B2 (en) 1987-04-02
ATE30592T1 (de) 1987-11-15
DK22983A (da) 1983-07-23
FI830192L (fi) 1983-07-23
JPS58128389A (ja) 1983-07-30
NO830183L (no) 1983-07-25
PL245814A1 (en) 1984-09-24
GR77867B (es) 1984-09-25
ES525612A0 (es) 1985-02-01
AU1064083A (en) 1983-07-28
ES525614A0 (es) 1985-02-01
US4455314A (en) 1984-06-19
ES8503004A1 (es) 1985-02-01
ES525613A0 (es) 1985-02-01
PT76128A (en) 1983-02-01
CA1217479A (en) 1987-02-03
KR840003258A (ko) 1984-08-20

Similar Documents

Publication Publication Date Title
ES485188A1 (es) Procedimiento para preparar 1-piperazina-carboxamidas y car-botiamidas
JPS5742651A (en) Non-hygroscopic salt of 4-hydroxybutyric acid, manufacture and drug containing same
ES8407495A1 (es) Procedimiento para preparar sales por adicion de acidos de compuestos de cefem cristalizados
ES8401960A1 (es) Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
DE2860358D1 (en) Crystalline form of the sodium salt of an oxyimino derivative of the 7-aminothiazolylacetamido-cephalosporanic acid, process for its preparation and pharmaceutical compositions containing it
ES2001341A6 (es) Un procedimiento de producir un derivado de acido guanidinometilbenzoico.
ES8306137A1 (es) "procedimiento para la preparacion de nuevas amidas de acidos carboxilicos".
HU903092D0 (en) Process for the preparation of buten-carboxylic acid derivatives and pharmaceutical compositions containing such compounds
PT80791A (fr) Procede de preparation de nouvelles phenyl-naphtiridines utiles notamment comme medicaments anti-ulceres
ES8503006A1 (es) Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico
ES8407009A1 (es) Un procedimiento para preparar -15-desoxiespergualina.
ES8403463A1 (es) "un procedimiento para la preparacion de un compuesto de imidazol".
DE3277971D1 (en) Acylamino-4-aza-1-adamantanes, process for their preparation and their therapeutic use
ES8802612A1 (es) Procedimiento para preparar derivados de benzisoselenazolilo
ES466493A1 (es) Procedimiento de fabricacion de acidos a-aril-a -oxo-isovalericos.
JPS56167636A (en) Use of 4-phenyl-4-oxy-2-hydroxybutanoic acid substitution derivative as drug
ES8305759A1 (es) "un procedimiento para la preparacion de 1-(1,3-bendodioxol-5-il)-2-pirrolidinona".
ES8206544A1 (es) Procedimiento para la preparacion de 4-carbamoiloxi-oxaza- fosforinas
JPS51115402A (en) Process for preparation of alpha-amino acid
ES8305319A1 (es) "procedimiento para la preparacion de acidos antranilicos sustituidos con radicales basicos"
ES489664A1 (es) Procedimiento de preparacion de la sal de lisina (+) del a- cido (+) amino-3-(pirrolil-1')-4 -metil-fenil-acetico
ES8304924A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido glutamil-diaminopimelico que contiene una b-lactama.
IE40758L (en) Basic enol ether pharmaceuticals
JPS53119822A (en) Preparation of 2-dimethylaminoethylisothiocyanate
ES8304925A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido &-glutamil-diaminopimelilo.