ES8405393A1 - Un procedimiento para la preparacion de nuevos benzopiranos. - Google Patents
Un procedimiento para la preparacion de nuevos benzopiranos.Info
- Publication number
- ES8405393A1 ES8405393A1 ES521317A ES521317A ES8405393A1 ES 8405393 A1 ES8405393 A1 ES 8405393A1 ES 521317 A ES521317 A ES 521317A ES 521317 A ES521317 A ES 521317A ES 8405393 A1 ES8405393 A1 ES 8405393A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- benzopyranols
- antihypertensive
- hydrogen
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS BENZOPIRANOS.CONSISTE EN CICLAR UN COMPUESTO DE FORMULA (II) O UNA SAL METALICA DEL MISMO, TAL COMO SAL DE SODIO, PARA OBTENER UN COMPUESTO DE FORMULA (I), DONDE R1 Y R2 ES NITRO, CIANO O (ALQUIL C 1 A 3) CARBONILO, Y EL OTRO ES METOXI O AMINO; R3 Y R4 ES HIDROGENO O ALQUILO CON C 1 A 4 Y EL OTRO ES ALQUILO CON C 1 A 4, O ESPIROALQUILO CON C 3 A 6; R5 ES HIDROGENO, ALQUILO CON C 1 A 3 O ACILO CON C 1 A 8; N ES 1 O 2; SIENDO TRANS EL GRUPO LACTAMA AL GRUPO OR5; R1 Y R2 ES NITRO, CIANO O (ALQUILCON C 1 A 3) CARBONILO O UN GRUPO O ATOMO CONVERTIBLE EN ESTE Y EL OTRO ES METOXI O AMINO; X E Y ES CO Y EL OTRO ES (CH2)NB2; L1 ES UN GRUPO SALIENTE, Y EL GRUPO AMINO SUSTITUIDO ES TRANS AL GRUPO OR5.TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD REDUCTORA DE LA PRESION SANGUINEA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8210490 | 1982-04-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8405393A1 true ES8405393A1 (es) | 1984-06-01 |
ES521317A0 ES521317A0 (es) | 1984-06-01 |
Family
ID=10529622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521317A Granted ES521317A0 (es) | 1982-04-08 | 1983-04-07 | Un procedimiento para la preparacion de nuevos benzopiranos. |
Country Status (7)
Country | Link |
---|---|
US (2) | US4542149A (es) |
EP (1) | EP0091748B1 (es) |
JP (1) | JPS58188880A (es) |
AU (1) | AU1320683A (es) |
DE (1) | DE3364145D1 (es) |
ES (1) | ES521317A0 (es) |
ZA (1) | ZA832431B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0139992B1 (en) * | 1983-09-01 | 1988-12-28 | Beecham Group Plc | Chromanol derivatives |
GB8409745D0 (en) * | 1984-04-14 | 1984-05-23 | Beecham Group Plc | Active compounds |
ATE56007T1 (de) * | 1984-06-22 | 1990-09-15 | Beecham Group Plc | Wirksame benzopyranverbindungen. |
GB8419515D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
GB8419516D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
GB8513369D0 (en) * | 1985-05-28 | 1985-07-03 | Beecham Group Plc | Treatment |
EP0205292B1 (en) | 1985-06-08 | 1991-11-06 | Beecham Group Plc | Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
GB8521857D0 (en) * | 1985-09-03 | 1985-10-09 | Beecham Group Plc | Active compounds |
DE3669317D1 (de) * | 1985-09-11 | 1990-04-12 | Beecham Group Plc | Chromanderivate und aehnliche verbindungen mit blutdrucksenkender wirkung. |
GB8625185D0 (en) * | 1986-10-21 | 1986-11-26 | Beecham Group Plc | Active compounds |
DE3703227A1 (de) * | 1987-02-04 | 1988-08-18 | Hoechst Ag | Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
CA1308108C (en) * | 1987-10-27 | 1992-09-29 | Dominick A. Quagliato | Antihypertensive benzopyran derivatives |
GB8800199D0 (en) * | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
DE3811017A1 (de) * | 1988-03-31 | 1989-10-19 | Hoechst Ag | Ungesaettigte n-benzopyranyllactame |
DE3837809A1 (de) * | 1988-11-08 | 1990-05-10 | Merck Patent Gmbh | Tetralinderivate |
FR2639227A1 (fr) * | 1988-11-23 | 1990-05-25 | Sanofi Sa | Utilisation de derives du chromane pour le traitement des etats depressifs |
DE3918041A1 (de) * | 1989-06-02 | 1990-12-06 | Merck Patent Gmbh | Chromanderivate |
DE3926001A1 (de) * | 1989-08-05 | 1991-02-07 | Merck Patent Gmbh | Chromanderivate |
GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
US5254555A (en) * | 1989-10-30 | 1993-10-19 | Beecham Group P.L.C. | Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension |
US5276168A (en) * | 1990-06-18 | 1994-01-04 | E. R. Squibb & Sons, Inc. | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents |
JP3502403B2 (ja) * | 1991-12-16 | 2004-03-02 | アベンティス ファーマ株式会社 | 骨吸収抑制剤 |
US5540201A (en) * | 1994-07-29 | 1996-07-30 | Caterpillar Inc. | Engine compression braking apparatus and method |
US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
NZ333870A (en) * | 1996-07-26 | 2000-08-25 | Nissan Chemical Ind Ltd | 4-amino substituted chroman derivatives |
DE69921815T2 (de) | 1998-06-03 | 2005-11-10 | Nissan Chemical Industries, Ltd. | Indanderivate |
US6555574B1 (en) | 1999-09-24 | 2003-04-29 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
US6677371B1 (en) | 1999-10-05 | 2004-01-13 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
NZ529916A (en) | 2001-06-25 | 2005-04-29 | Nissan Chemical Ind Ltd | Substituted benzopyran derivatives against arrhythmia |
AU2003268683B2 (en) * | 2002-10-18 | 2009-09-03 | Nissan Chemical Industries, Ltd. | Process for production of an acetylenic compound |
KR20080112290A (ko) | 2006-03-10 | 2008-12-24 | 닛산 가가쿠 고교 가부시키 가이샤 | 광학 활성 크로멘 옥사이드화합물의 제조 방법 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1495526A (en) * | 1974-05-31 | 1977-12-21 | Beecham Group Ltd | Chroman derivatives |
GB1548221A (en) * | 1976-01-27 | 1979-07-04 | Beecham Group Ltd | Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters |
GB1511187A (en) * | 1976-04-02 | 1978-05-17 | Beecham Group Ltd | Chromans |
NZ183551A (en) * | 1976-04-02 | 1978-09-20 | Beecham Group Ltd | Aminochromanols and pharmaceutical compositions containingthem |
US4391815A (en) * | 1976-04-02 | 1983-07-05 | Beecham Group Limited | Cyanobenzano[b]pyrans |
GB1548222A (en) * | 1976-12-17 | 1979-07-04 | Beecham Group Ltd | Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives |
DE2965739D1 (en) * | 1978-10-04 | 1983-07-28 | Beecham Group Plc | Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them |
EP0028064B1 (en) * | 1979-09-28 | 1983-07-20 | Beecham Group Plc | Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them |
DE3064285D1 (en) * | 1979-09-28 | 1983-08-25 | Beecham Group Plc | Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them |
DE2950479A1 (de) * | 1979-12-14 | 1981-06-19 | A. Nattermann & Cie GmbH, 5000 Köln | N-(3-alkylamino-2-hydroxypropoxy-phenyl)-lactame, deren herstellungsverfahren und arzneimitttel auf deren basis |
DE3170604D1 (en) * | 1980-08-21 | 1985-06-27 | Beecham Group Plc | Chromanol derivatives, their production and pharmaceutical compositions containing them |
GB2107706A (en) * | 1981-09-25 | 1983-05-05 | Beecham Group Plc | Benzopyrans |
EP0093535B1 (en) * | 1982-04-28 | 1986-12-30 | Beecham Group Plc | Novel chromenes and chromans |
-
1983
- 1983-03-24 EP EP83301649A patent/EP0091748B1/en not_active Expired
- 1983-03-24 DE DE8383301649T patent/DE3364145D1/de not_active Expired
- 1983-04-06 US US06/482,628 patent/US4542149A/en not_active Expired - Fee Related
- 1983-04-06 AU AU13206/83A patent/AU1320683A/en not_active Abandoned
- 1983-04-07 ES ES521317A patent/ES521317A0/es active Granted
- 1983-04-07 ZA ZA832431A patent/ZA832431B/xx unknown
- 1983-04-07 JP JP58061516A patent/JPS58188880A/ja active Pending
-
1984
- 1984-12-18 US US06/683,018 patent/US4644070A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4542149A (en) | 1985-09-17 |
JPS58188880A (ja) | 1983-11-04 |
DE3364145D1 (de) | 1986-07-24 |
US4644070A (en) | 1987-02-17 |
AU1320683A (en) | 1983-10-13 |
ES521317A0 (es) | 1984-06-01 |
ZA832431B (en) | 1984-03-28 |
EP0091748A1 (en) | 1983-10-19 |
EP0091748B1 (en) | 1986-06-18 |
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