ES8402304A1 - Un procedimiento para la preparacion de octahidrobenzofuro (3-2-e) isoquinolinas. - Google Patents
Un procedimiento para la preparacion de octahidrobenzofuro (3-2-e) isoquinolinas.Info
- Publication number
- ES8402304A1 ES8402304A1 ES518514A ES518514A ES8402304A1 ES 8402304 A1 ES8402304 A1 ES 8402304A1 ES 518514 A ES518514 A ES 518514A ES 518514 A ES518514 A ES 518514A ES 8402304 A1 ES8402304 A1 ES 8402304A1
- Authority
- ES
- Spain
- Prior art keywords
- yield
- aryl
- derivative
- isoquinolinol
- octahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE OCTAHIDROBENZOFURO [3,2-E] ISOQUINOLINAS, DE FORMULA (I), EN LA QUE R ELEVADO 3, R ELEVADO 4 Y R ELEVADO 5 SON HIDROGENO Y R ELEVADO 1 Y R ELEVADO 2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE ENLA REACCION DE UN ANISOL LITIADO O UN ALQUILFENILETER LITIADO, CON UNA 4-PIPERIDONA PARA FORMAR UN 4-ARIAL-4-PIPERIDINOL, SEGUIDA DE LA DESHIDRATACION A UNA 4-ARIAL-1,2,3,6-TETRAHIDROPIRIDINA; METALACION Y ACILACION E ESTA; REDUCCION DEL RADICAL CETONA Y CONVERSION DEL ACOHOL FORMADO A UN COMPUESTO DE FORMULA (II), EN LA QUE R ELEVADO 10 ES ALQUILO Y R ELEVADO 1 Y R ELEVADO 2 SON LOS MISMOS QUE EN LA FORMULA (I); APERTURA DEL ANILLO DE AMINOFURANO; CIERRE DEL ANILLO DE 6 CARBONOS DEL DERIVADO DE BUTANOL; REACCION DEL ISOQUINOLINOL CON UN REDUCTOR Y TRATAMIENTO DEL PRODUCTO FORMADO CON UN ACIDO O UNA BASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANALGESICOS Y ANTAGONISTAS DE LOS NARCOTICOS. *FORMULA*.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/334,838 US4415736A (en) | 1981-12-28 | 1981-12-28 | Certain tetrahydropyridine intermediates |
US06/334,839 US4421916A (en) | 1981-12-28 | 1981-12-28 | Intermediates for octahydrobenzofuro[3,2-e]isoquinolines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8402304A1 true ES8402304A1 (es) | 1984-02-01 |
ES518514A0 ES518514A0 (es) | 1984-02-01 |
Family
ID=26989416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES518514A Granted ES518514A0 (es) | 1981-12-28 | 1982-12-23 | Un procedimiento para la preparacion de octahidrobenzofuro (3-2-e) isoquinolinas. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0083093A3 (es) |
AU (1) | AU9183682A (es) |
DK (1) | DK568482A (es) |
ES (1) | ES518514A0 (es) |
FI (1) | FI824467L (es) |
GR (1) | GR78414B (es) |
IL (1) | IL67563A0 (es) |
NO (3) | NO824375L (es) |
PT (1) | PT76038B (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB832490A (en) * | 1957-03-05 | 1960-04-13 | Beckett Arnold Heyworth | Amino-alcohols and amino-esters |
US3850935A (en) * | 1971-10-16 | 1974-11-26 | Sumitomo Chemical Co | Process for producing piperidine derivatives by degrading quaternary piperidinium salts |
US4243668A (en) * | 1979-07-09 | 1981-01-06 | E. I. Du Pont De Nemours And Company | Octahydro-1H-benzo[4,5]furo[3,2-e]-isoquinoline analgesic and narcotic antagonistic compounds |
US4236009A (en) * | 1979-06-21 | 1980-11-25 | Eli Lilly And Company | Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines |
-
1982
- 1982-12-22 DK DK568482A patent/DK568482A/da not_active Application Discontinuation
- 1982-12-23 EP EP82111983A patent/EP0083093A3/en not_active Withdrawn
- 1982-12-23 GR GR70163A patent/GR78414B/el unknown
- 1982-12-23 AU AU91836/82A patent/AU9183682A/en not_active Abandoned
- 1982-12-23 ES ES518514A patent/ES518514A0/es active Granted
- 1982-12-27 PT PT76038A patent/PT76038B/pt unknown
- 1982-12-27 IL IL67563A patent/IL67563A0/xx unknown
- 1982-12-27 FI FI824467A patent/FI824467L/fi not_active Application Discontinuation
- 1982-12-27 NO NO824375A patent/NO824375L/no unknown
-
1983
- 1983-08-12 NO NO832911A patent/NO832911L/no unknown
- 1983-08-12 NO NO832912A patent/NO832912L/no unknown
Also Published As
Publication number | Publication date |
---|---|
PT76038A (en) | 1983-01-01 |
PT76038B (en) | 1985-12-16 |
NO832912L (no) | 1983-06-29 |
AU9183682A (en) | 1983-07-07 |
IL67563A0 (en) | 1983-05-15 |
DK568482A (da) | 1983-06-29 |
EP0083093A2 (en) | 1983-07-06 |
EP0083093A3 (en) | 1984-05-23 |
NO832911L (no) | 1983-06-29 |
NO824375L (no) | 1983-06-29 |
GR78414B (es) | 1984-09-27 |
FI824467L (fi) | 1983-06-29 |
ES518514A0 (es) | 1984-02-01 |
FI824467A0 (fi) | 1982-12-27 |
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