ES8402278A1 - "procedimiento para la fabricacion de derivados de 5-aminoisoxazol". - Google Patents
"procedimiento para la fabricacion de derivados de 5-aminoisoxazol".Info
- Publication number
- ES8402278A1 ES8402278A1 ES516787A ES516787A ES8402278A1 ES 8402278 A1 ES8402278 A1 ES 8402278A1 ES 516787 A ES516787 A ES 516787A ES 516787 A ES516787 A ES 516787A ES 8402278 A1 ES8402278 A1 ES 8402278A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- substituted
- phenyl
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IAXWZYXUKABJAN-UHFFFAOYSA-N 1,2-oxazol-5-amine Chemical class NC1=CC=NO1 IAXWZYXUKABJAN-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- -1 hexamethyleneimino group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LAOBTENCION DE DERIVADOS DE 5-AMINOISOXAZOL Y DE SUS SALES NO TOXICAS, DE FORMULA (I), EN LA QUE R1, R2, R3 Y D PUEDEN SER VARIOS RADICALES; R4 Y R5 SON HIDROGENO O ALQUILO INFERIOR; Y B ELEVADO , ES METILENO SIN SUSTITUIR O SUSTITUIDO CON ALQUILO INFERIOR. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA H-D, EN LAS QUE R PUEDE SER VARIOS TIPOS DE RADICALES Y R1, R2, R3 Y D TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA 8I). LA REACCION SE LLEVA A CABO EN AUSENCIA O EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE 0GC Y 100GC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO RELAJANTES MUSCULARES Y POR SU ACCION EN EL SISTEMA NERVIOSO CENTRAL. *FORMULA*. T
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56161206A JPS5862169A (ja) | 1981-10-09 | 1981-10-09 | 新規な５−アミノイソオキサゾ−ル誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8402278A1 true ES8402278A1 (es) | 1984-02-01 |
| ES516787A0 ES516787A0 (es) | 1984-02-01 |
Family
ID=15730608
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES516787A Granted ES516787A0 (es) | 1981-10-09 | 1982-10-08 | "procedimiento para la fabricacion de derivados de 5-aminoisoxazol". |
| ES526914A Expired ES8504156A1 (es) | 1981-10-09 | 1983-10-31 | Procedimiento perfeccionado para la fabricacion de derivados de 5-aminoisoxazol |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526914A Expired ES8504156A1 (es) | 1981-10-09 | 1983-10-31 | Procedimiento perfeccionado para la fabricacion de derivados de 5-aminoisoxazol |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5862169A (es) |
| DE (1) | DE3237149A1 (es) |
| ES (2) | ES516787A0 (es) |
| FR (1) | FR2514354A1 (es) |
| GB (1) | GB2107710A (es) |
| IT (1) | IT8223685A0 (es) |
| SE (1) | SE8205583L (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338857A (en) * | 1989-08-04 | 1994-08-16 | Mitsui Toatsu Chemicals Incorporated | Aminoketone derivatives of 1,2-oxazole and use thereof |
| JPH0625178B2 (ja) * | 1989-08-04 | 1994-04-06 | 三井東圧化学株式会社 | アミノケトン誘導体及びその用途 |
| JPH04368375A (ja) * | 1991-06-17 | 1992-12-21 | Otsuka Pharmaceut Factory Inc | イソオキサゾール誘導体 |
| US6544982B1 (en) * | 1999-10-29 | 2003-04-08 | Merck & Co., Inc. | Thrombin receptor antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2068418A1 (en) * | 1969-10-27 | 1971-08-27 | Innothera Lab Sa | 2-substd-5-amino isoxazole derivs |
-
1981
- 1981-10-09 JP JP56161206A patent/JPS5862169A/ja active Pending
-
1982
- 1982-09-30 SE SE8205583A patent/SE8205583L/xx not_active Application Discontinuation
- 1982-10-07 DE DE19823237149 patent/DE3237149A1/de not_active Withdrawn
- 1982-10-08 FR FR8216914A patent/FR2514354A1/fr not_active Withdrawn
- 1982-10-08 GB GB08228896A patent/GB2107710A/en not_active Withdrawn
- 1982-10-08 ES ES516787A patent/ES516787A0/es active Granted
- 1982-10-08 IT IT8223685A patent/IT8223685A0/it unknown
-
1983
- 1983-10-31 ES ES526914A patent/ES8504156A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE8205583L (sv) | 1983-04-10 |
| DE3237149A1 (de) | 1983-04-21 |
| ES526914A0 (es) | 1985-04-01 |
| ES516787A0 (es) | 1984-02-01 |
| JPS5862169A (ja) | 1983-04-13 |
| SE8205583D0 (sv) | 1982-09-30 |
| FR2514354A1 (fr) | 1983-04-15 |
| ES8504156A1 (es) | 1985-04-01 |
| GB2107710A (en) | 1983-05-05 |
| IT8223685A0 (it) | 1982-10-08 |
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