ES8402258A1 - Derivados salicilicos de n-acetilcisteina. - Google Patents
Derivados salicilicos de n-acetilcisteina.Info
- Publication number
- ES8402258A1 ES8402258A1 ES517540A ES517540A ES8402258A1 ES 8402258 A1 ES8402258 A1 ES 8402258A1 ES 517540 A ES517540 A ES 517540A ES 517540 A ES517540 A ES 517540A ES 8402258 A1 ES8402258 A1 ES 8402258A1
- Authority
- ES
- Spain
- Prior art keywords
- acetylcysteine
- acid
- reaction
- salicylic derivatives
- acetylsalicylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical class CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title abstract 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 2
- 229960004308 acetylcysteine Drugs 0.000 abstract 2
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 230000000510 mucolytic effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT25198/81A IT1194117B (it) | 1981-11-20 | 1981-11-20 | Derivati salicilici di n-acetilcisteina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES517540A0 ES517540A0 (es) | 1984-01-16 |
| ES8402258A1 true ES8402258A1 (es) | 1984-01-16 |
Family
ID=11215991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES517540A Expired ES8402258A1 (es) | 1981-11-20 | 1982-11-19 | Derivados salicilicos de n-acetilcisteina. |
Country Status (9)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU574360B2 (en) * | 1983-05-13 | 1988-07-07 | Reichert, D. | Antisnoring agent |
| IT1206515B (it) * | 1983-08-09 | 1989-04-27 | Guidotti & C Spa Labor | N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche. |
| IT1194474B (it) * | 1983-11-23 | 1988-09-22 | Magis Farmaceutici | Derivati della cisteina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| CA2164955A1 (en) * | 1993-06-18 | 1995-01-05 | Richard J. Sharpe | Method for treating hyperkeratosis and diseases mediated by proteases |
| US5637616A (en) * | 1993-06-18 | 1997-06-10 | Arcturus Pharmaceutical Corporation | Method for treating diseases mediated by proteases |
| AU2825295A (en) * | 1994-06-13 | 1996-01-05 | Arcturus Pharmaceutical Corporation | Method for the treatment, prevention or minimization of hair loss |
| GB2320431B (en) * | 1996-12-20 | 2000-08-30 | Johnson & Johnson Medical | Compositions for the treatment of chronic wounds |
| JP5669729B2 (ja) * | 2008-05-13 | 2015-02-12 | ジェンメディカ・セラピューティックス・ソシエダッド・リミターダＧｅｎｍｅｄｉｃａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓｌ | 代謝性障害を治療するのに有用なサリチレートコンジュゲート |
| US8575217B2 (en) | 2009-03-16 | 2013-11-05 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| CN102421424A (zh) * | 2009-03-16 | 2012-04-18 | 根梅迪卡治疗公司 | 用于治疗代谢性疾病的组合疗法 |
| US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
| WO2013037984A1 (en) | 2011-09-16 | 2013-03-21 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| BR112014006150A2 (pt) | 2011-09-16 | 2017-04-04 | Genmedica Therapeutics Sl | combinação farmacêutica, e, métodos para tratar doença, síndrome ou condição, e para proteger beta-células pancreáticas |
| PT3066089T (pt) | 2013-11-08 | 2020-01-29 | Promentis Pharm Inc | Derivados n-acetil-l-cisteína substituídos e compostos relacionados |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR4619M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1965-02-01 | 1966-11-28 | ||
| US4268456A (en) * | 1979-09-24 | 1981-05-19 | Ppg Industries, Inc. | Process for preparing chlorothiolformates |
-
1981
- 1981-11-20 IT IT25198/81A patent/IT1194117B/it active
-
1982
- 1982-11-12 DE DE8282201443T patent/DE3262569D1/de not_active Expired
- 1982-11-12 AT AT82201443T patent/ATE12102T1/de not_active IP Right Cessation
- 1982-11-12 EP EP82201443A patent/EP0080229B1/en not_active Expired
- 1982-11-16 CA CA000415702A patent/CA1202618A/en not_active Expired
- 1982-11-16 US US06/442,044 patent/US4567163A/en not_active Expired - Lifetime
- 1982-11-19 ES ES517540A patent/ES8402258A1/es not_active Expired
- 1982-11-19 KR KR8205229A patent/KR890000618B1/ko not_active Expired
- 1982-11-20 JP JP57204423A patent/JPS58146560A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IT8125198A0 (it) | 1981-11-20 |
| US4567163A (en) | 1986-01-28 |
| JPH059424B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-02-04 |
| ES517540A0 (es) | 1984-01-16 |
| KR840002350A (ko) | 1984-06-25 |
| KR890000618B1 (ko) | 1989-03-22 |
| ATE12102T1 (de) | 1985-03-15 |
| EP0080229A1 (en) | 1983-06-01 |
| EP0080229B1 (en) | 1985-03-13 |
| DE3262569D1 (en) | 1985-04-18 |
| JPS58146560A (ja) | 1983-09-01 |
| IT1194117B (it) | 1988-09-14 |
| CA1202618A (en) | 1986-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8402258A1 (es) | Derivados salicilicos de n-acetilcisteina. | |
| ES8106513A1 (es) | Procedimiento para la preparacion de sales de la (+)-cate- quina | |
| ES390860A1 (es) | Procedimiento para la produccion de un acido alfa - halofe-nilacetico sustituido. | |
| JPS52128293A (en) | Preparation of 7-aminocephalosporanic acid and its derivatives | |
| ATE35811T1 (de) | Derivat der acetylsalicylsaeure, seine herstellung und dieses enthaltende pharmazeutische kompositionen. | |
| ES534958A0 (es) | Procedimiento de preparar derivados cisteinicos | |
| JPS5266885A (en) | Gel composition containing water soluble organic medium | |
| GB1359560A (en) | Preparation of pyrrylsalicylic acid | |
| BE816076A (en) | N-cyclohexyl-N'-substd-phenyl-benzamides - having anti-inflammatory and analgesic activity with low toxicity | |
| GB1467528A (en) | Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate | |
| GB1408971A (en) | Process for producing indan-1-carboxylic acid derivatives | |
| FR2044356A5 (en) | 2-phenyl propionyl salicylic acid and salts - analgesics and antipyretics | |
| ES430201A1 (es) | Procedimiento para la preparacion de n-(heteroarilmetil - delta7-desoxi-normorfinas y -norcodeinas. | |
| JPS5323916A (en) | Preparation of thioglycosides | |
| ES8800144A1 (es) | Procedimiento de obtencion de un tioester de la n-acetilcisteina y de sus sales de interes terapeutico | |
| GB1414793A (en) | Derivatives of phenylaminopyridine | |
| JPS5340734A (en) | Preparation of phenylacetic acid derivatives | |
| GB1214533A (en) | New acetylsalicylic acid derivatives and compositions containing the same | |
| JPS5328119A (en) | Preparation of pantetheine | |
| DE3571394D1 (en) | A (-) campholenic acid ester of salicylic acid having mucosecretolytic, anti-inflammatory, analgesic antipyretic activity, suitable to provide pharmaceutically acceptable salts; a process for its preparation and pharmaceutical compositions containing the ester or the salts thereof | |
| JPS52118448A (en) | Synthesis of cyclohexanedione derivatives | |
| Sampat et al. | Sodium Diethyldithiocarbamate as an Inhibitor for the Corrosion of Aluminum in Trichloroacetic Acid | |
| GB1345358A (en) | Antiinflammatory preparations | |
| KR870000071A (ko) | 수의 운동을 개선하는 신규약제 조성물 및 그의 생산공정 | |
| JPS5338688A (en) | Immobilizing glucoseisomerase |