IT1194117B - Derivati salicilici di n-acetilcisteina - Google Patents

Derivati salicilici di n-acetilcisteina

Info

Publication number
IT1194117B
IT1194117B IT25198/81A IT2519881A IT1194117B IT 1194117 B IT1194117 B IT 1194117B IT 25198/81 A IT25198/81 A IT 25198/81A IT 2519881 A IT2519881 A IT 2519881A IT 1194117 B IT1194117 B IT 1194117B
Authority
IT
Italy
Prior art keywords
acetylcysteine
acid
acetylcistein
reaction
acetylsalicylic acid
Prior art date
Application number
IT25198/81A
Other languages
English (en)
Italian (it)
Other versions
IT8125198A0 (it
Inventor
Osvaldo Ponchiroli
Original Assignee
Isnardi Pietro & C Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isnardi Pietro & C Spa filed Critical Isnardi Pietro & C Spa
Publication of IT8125198A0 publication Critical patent/IT8125198A0/it
Priority to IT25198/81A priority Critical patent/IT1194117B/it
Priority to AT82201443T priority patent/ATE12102T1/de
Priority to EP82201443A priority patent/EP0080229B1/en
Priority to DE8282201443T priority patent/DE3262569D1/de
Priority to US06/442,044 priority patent/US4567163A/en
Priority to CA000415702A priority patent/CA1202618A/en
Priority to ES517540A priority patent/ES517540A0/es
Priority to KR8205229A priority patent/KR890000618B1/ko
Priority to JP57204423A priority patent/JPS58146560A/ja
Application granted granted Critical
Publication of IT1194117B publication Critical patent/IT1194117B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/10Expectorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
IT25198/81A 1981-11-20 1981-11-20 Derivati salicilici di n-acetilcisteina IT1194117B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT25198/81A IT1194117B (it) 1981-11-20 1981-11-20 Derivati salicilici di n-acetilcisteina
AT82201443T ATE12102T1 (de) 1981-11-20 1982-11-12 Salicylderivate von n-acetyl-cystein.
EP82201443A EP0080229B1 (en) 1981-11-20 1982-11-12 Salicylic derivatives of n-acetylcysteine
DE8282201443T DE3262569D1 (en) 1981-11-20 1982-11-12 Salicylic derivatives of n-acetylcysteine
US06/442,044 US4567163A (en) 1981-11-20 1982-11-16 Salicyclic acid derivatives of N-acetylcysteine and pharmacological use thereof
CA000415702A CA1202618A (en) 1981-11-20 1982-11-16 Salicylic derivatives of n-acetyl-cysteine
ES517540A ES517540A0 (es) 1981-11-20 1982-11-19 Derivados salicilicos de n-acetilcisteina.
KR8205229A KR890000618B1 (ko) 1981-11-20 1982-11-19 N-아세틸시스테인의 살리실산 유도체의 제조방법
JP57204423A JPS58146560A (ja) 1981-11-20 1982-11-20 N―アセチルシステインのサリチル誘導体及びその製造方法並びにこの誘導体を用いた薬剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT25198/81A IT1194117B (it) 1981-11-20 1981-11-20 Derivati salicilici di n-acetilcisteina

Publications (2)

Publication Number Publication Date
IT8125198A0 IT8125198A0 (it) 1981-11-20
IT1194117B true IT1194117B (it) 1988-09-14

Family

ID=11215991

Family Applications (1)

Application Number Title Priority Date Filing Date
IT25198/81A IT1194117B (it) 1981-11-20 1981-11-20 Derivati salicilici di n-acetilcisteina

Country Status (9)

Country Link
US (1) US4567163A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0080229B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58146560A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR890000618B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE12102T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1202618A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3262569D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES517540A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1194117B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU574360B2 (en) * 1983-05-13 1988-07-07 Reichert, D. Antisnoring agent
IT1206515B (it) * 1983-08-09 1989-04-27 Guidotti & C Spa Labor N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
IT1194474B (it) * 1983-11-23 1988-09-22 Magis Farmaceutici Derivati della cisteina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
JPH11501611A (ja) * 1993-06-18 1999-02-09 アークチュラス、ファーマシューティカル、コーポレーション 過角化及びプロテアーゼによって媒介される疾患の治療のための方法
US5637616A (en) * 1993-06-18 1997-06-10 Arcturus Pharmaceutical Corporation Method for treating diseases mediated by proteases
AU2825295A (en) * 1994-06-13 1996-01-05 Arcturus Pharmaceutical Corporation Method for the treatment, prevention or minimization of hair loss
GB2320431B (en) * 1996-12-20 2000-08-30 Johnson & Johnson Medical Compositions for the treatment of chronic wounds
AU2009248057B2 (en) * 2008-05-13 2013-02-21 Genmedica Therapeutics Sl Salicylate conjugates useful for treating metabolic disorders
BRPI1011593A2 (pt) * 2009-03-16 2016-03-22 Genmedica Therapeutics Sl "combinação farmacêutica, composição farmaceuticamente aceitavél, e, método para tratar um distúrbio metabólico, para tratar doença pulmonar obstrutiva crônica, e para tratar ou prevenir um ou mais distúrbios metabólicos."
BRPI1013878A2 (pt) * 2009-03-16 2016-04-05 Genmedica Therapeutics Sl método para tratar distúrbios metabólicos, e, composto
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
WO2013037984A1 (en) 2011-09-16 2013-03-21 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
WO2013037985A1 (en) 2011-09-16 2013-03-21 Genmedica Theraputics Sl Pharmaceutical combinations including anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
EP3066089B1 (en) 2013-11-08 2019-11-06 Promentis Pharmaceuticals, Inc. Substituted n-acetyl-l-cysteine derivatives and related compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4619M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1965-02-01 1966-11-28
US4268456A (en) * 1979-09-24 1981-05-19 Ppg Industries, Inc. Process for preparing chlorothiolformates

Also Published As

Publication number Publication date
KR890000618B1 (ko) 1989-03-22
KR840002350A (ko) 1984-06-25
CA1202618A (en) 1986-04-01
JPS58146560A (ja) 1983-09-01
ES8402258A1 (es) 1984-01-16
JPH059424B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-02-04
US4567163A (en) 1986-01-28
EP0080229A1 (en) 1983-06-01
DE3262569D1 (en) 1985-04-18
ES517540A0 (es) 1984-01-16
EP0080229B1 (en) 1985-03-13
ATE12102T1 (de) 1985-03-15
IT8125198A0 (it) 1981-11-20

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971127