ES8401945A1 - Procedimiento para preparar derivados de dibenzo(de,g)quinoleina. - Google Patents

Procedimiento para preparar derivados de dibenzo(de,g)quinoleina.

Info

Publication number
ES8401945A1
ES8401945A1 ES521140A ES521140A ES8401945A1 ES 8401945 A1 ES8401945 A1 ES 8401945A1 ES 521140 A ES521140 A ES 521140A ES 521140 A ES521140 A ES 521140A ES 8401945 A1 ES8401945 A1 ES 8401945A1
Authority
ES
Spain
Prior art keywords
dibenzo
preparation
processes
quinolines
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521140A
Other languages
English (en)
Other versions
ES521140A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Publication of ES521140A0 publication Critical patent/ES521140A0/es
Publication of ES8401945A1 publication Critical patent/ES8401945A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE DIBENZO (DE, G) QUINOLEINA.CONSISTE EN LA OBTENCION DE COMPUESTOS DE FORMULA GENERAL (I) A PARTIR DE LOS METODOS SIGUIENTES: A) SOMETER A N-ALQUENILACION, N-ALQUINILACION O N-CICLOALCOHILACION COMPUESTOS DE FORMULA GENERAL (II) Y POSTERIOR CICLISACION, SEGUIDA DE O-METILACION; B) SOMETER A N-ALQUENILACION, N-ALQUINILACION O N-CICLOALCOHILALCOHILACION COMPUESTOS DE FORMULA (III), POSTERIOR CICLISACION Y SUBSIGUIENTE O-METILACION, DONDE R ES UN RADICAL HIDROCARBONADO ALIFATICO INSATURADO DE C 1 A 6, O UN RADICAL CICLOALCOHILALCOHILO DE C 4 A6, POR EJEMPLO, UN RADICAL ALILO, METALILO, DIMETILALILO, BUT-2-ENILO Y OTROS; R Y R SON ATOMOS DE HIDROGENO O RADICALES DE METILO. LA N-ALQUINILACION, N-ALQUENILACION O N-CICLOALCOHILALCOHILACION TIENE LUGAR MEDIANTE DERIVADOS REACTIVOS DE FORMULA GENERAL X-R, DONDE X ES UN ATOMO DE HALOGENO.TIENE APLICACIONES FARMACOLOGICAS POR SU ACCION ANALGESICA Y ANTIALERGICA.
ES521140A 1981-05-09 1983-03-30 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina. Expired ES8401945A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813118521 DE3118521A1 (de) 1981-05-09 1981-05-09 Dibenzo(de,g)chinolin-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkaeltungskrankheiten und allergien

Publications (2)

Publication Number Publication Date
ES521140A0 ES521140A0 (es) 1984-01-01
ES8401945A1 true ES8401945A1 (es) 1984-01-01

Family

ID=6131937

Family Applications (3)

Application Number Title Priority Date Filing Date
ES511983A Expired ES8401470A1 (es) 1981-05-09 1982-05-07 "procedimiento para preparar derivados de dibenzo quinoleina".
ES521140A Expired ES8401945A1 (es) 1981-05-09 1983-03-30 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina.
ES524475A Granted ES524475A0 (es) 1981-05-09 1983-07-27 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES511983A Expired ES8401470A1 (es) 1981-05-09 1982-05-07 "procedimiento para preparar derivados de dibenzo quinoleina".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES524475A Granted ES524475A0 (es) 1981-05-09 1983-07-27 Procedimiento para preparar derivados de dibenzo(de,g)quinoleina

Country Status (5)

Country Link
US (1) US4461895A (es)
EP (1) EP0064685A1 (es)
JP (1) JPS57192369A (es)
DE (1) DE3118521A1 (es)
ES (3) ES8401470A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210680B1 (en) 1999-06-11 2001-04-03 Univera Pharmaceuticals, Inc. Method for the prevention and treatment of chronic venous insufficiency
TWI225397B (en) * 2000-05-04 2004-12-21 Nat Science Council Uses of thaliporphine or its derivatives in treatment of cardiac diseases and preparation of the same
DE60119336T2 (de) * 2000-08-23 2007-05-10 Lotus Pharmaceutical Co., Ltd. Verwendungen von thaliporphin oder seinen derivaten in der behandlung von herzkrankheiten und seine herstellung
DE60226332T2 (de) 2001-08-24 2009-07-09 Waddington North America, Inc., Chelmsford Metallisiertes besteck
US20060191145A1 (en) * 2001-08-24 2006-08-31 Waddington North America, Inc. Metallized cutlery and tableware and method therefor
EP1634596A4 (en) * 2003-06-19 2006-06-21 Lotus Pharmaceutical Co Ltd APORPHINE AND OXOPHORPHINE AND ITS MEDICAL USE
DE10345572A1 (de) * 2003-09-29 2005-05-19 Covion Organic Semiconductors Gmbh Metallkomplexe
KR101079927B1 (ko) 2010-11-24 2011-11-04 동아제약주식회사 퀴놀린 유도체 화합물, 이의 제조방법 및 이를 포함하는 약학 조성물
CN106632041B (zh) * 2016-10-11 2019-07-12 安徽省逸欣铭医药科技有限公司 一种酒石酸左洛啡烷的制备方法
CN111196801B (zh) * 2020-01-14 2022-10-14 中国药科大学 阿朴菲类生物碱衍生物及其制备方法与用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3717643A (en) * 1967-05-04 1973-02-20 Sterling Drug Inc N-substituted-norapomorphines
DE2757335C3 (de) * 1977-12-22 1982-03-25 Gödecke AG, 1000 Berlin Verfahren zur O-Methylierung von Hydroxyaporphinen
DE3013346A1 (de) * 1980-04-05 1981-10-15 Gödecke AG, 1000 Berlin Dibenz(de,g)isochinolin-derivate, verfahren zu deren herstellung, diese enthaltende arzneimittel sowie deren verwendung bei der bekaempfung von erkrankungen des zentralen nervensystems
EP0040074B1 (en) * 1980-05-08 1985-07-31 Northeastern University N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same

Also Published As

Publication number Publication date
ES8406443A1 (es) 1984-07-16
ES511983A0 (es) 1983-12-01
DE3118521A1 (de) 1982-12-02
US4461895A (en) 1984-07-24
ES524475A0 (es) 1984-07-16
ES521140A0 (es) 1984-01-01
ES8401470A1 (es) 1983-12-01
JPS57192369A (en) 1982-11-26
EP0064685A1 (de) 1982-11-17

Similar Documents

Publication Publication Date Title
AU553419B2 (en) New deiphosphonic acid derivatives
TW239126B (es)
ES487677A1 (es) Procedimiento para la preparacion de derivados de aril-ete- res
ES8306142A1 (es) "procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil)-bencimidazolonas sustituidas".
ES8401470A1 (es) "procedimiento para preparar derivados de dibenzo quinoleina".
ES2001341A6 (es) Un procedimiento de producir un derivado de acido guanidinometilbenzoico.
ES2001094A6 (es) Un procedimiento para la preparacion de un derivado de guanina
AU557954B2 (en) Diethylaminoalkoxy-benzhydrol derivatives
ES8601915A1 (es) Un procedimiento para preparar derivados de piridazinona
DE3363550D1 (en) New nitro aliphatic compounds, process for preparation thereof and use thereof
ES8404360A1 (es) Un procedimiento para preparar compuestos de cefem.
AU558261B2 (en) Dialkylaminoalkyoxybenzylalcohol derivatives
ES8205770A1 (es) Procedimiento para la preparacion de derivados de 2,3-indo- lediona
JPS57185282A (en) Benzopyrane ether, manufacture and anti-allergic medicine containing same
EP0189272A3 (en) New furanone derivatives, processes for preparation thereof and use thereof
ES2001893A6 (es) Procedimiento para la obtencion de derivados de metilendioxifenantreno
IL60176A (en) (aminopiperidinopropyl)dimethyl xanthine derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
NZ218918A (en) 4-oxo-1,4-dihydro-quinoline 3-carboxamides,their preparation and pharmaceutical compositions containing them
ES8307242A1 (es) Un procedimiento para la preparacion de 3(2-(3-alquil y alquenil-4-piperidil))indoles.
ES8103079A1 (es) Un procedimiento para preparar derivados de fenotiazina
GR78773B (es)
AU7998087A (en) 1-hydroxyalkylxanthines, processes for their preparation and medicaments containing them
ES8307790A1 (es) Un procedimiento para preparacion de 3-(2-(4-piperidil)-1-alquiletil) indoles.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001