ES8306114A1 - "procedimiento para la preparacion de una sulfonilurea". - Google Patents
"procedimiento para la preparacion de una sulfonilurea".Info
- Publication number
- ES8306114A1 ES8306114A1 ES515395A ES515395A ES8306114A1 ES 8306114 A1 ES8306114 A1 ES 8306114A1 ES 515395 A ES515395 A ES 515395A ES 515395 A ES515395 A ES 515395A ES 8306114 A1 ES8306114 A1 ES 8306114A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- atoms
- pharmaceutical compositions
- compositions containing
- sulfonyl ureas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE SULFONILUREAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE Y ES ALCOHILENO C <- ; R ES ALCOHILO C <- ; R ES HIDROGENO, CLORO O METILO; Y R PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE DESDOBLAMIENTO DE BENZOSULFONIL-ISOUREA-ETERES, BENZOSULFONIL-ISOTIOUREA-ETERES, ACIDOS BENZOSULFONIL-PARABANICOS O AMIDINAS DE ACIDOS BENZOSULFONIL-HALOGENOFORMICOS, SUSTITUIDOS CON EL GRUPO DE FORMULA (II), EN LA QUE Y, R Y R TIENEN EL MISMO SIGNIFICADO QUE QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, O EN MEDIO ACIDO, A LA TEMPERATURA AMBIENTE O SUPERIOR. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES HIPOGLUCEMICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813134780 DE3134780A1 (de) | 1981-09-02 | 1981-09-02 | "sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung" |
Publications (2)
Publication Number | Publication Date |
---|---|
ES515395A0 ES515395A0 (es) | 1983-05-01 |
ES8306114A1 true ES8306114A1 (es) | 1983-05-01 |
Family
ID=6140704
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515399A Expired ES8306118A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
ES515395A Expired ES8306114A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
ES515396A Expired ES8306115A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
ES515384A Expired ES8306113A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una solfonilurea". |
ES515397A Expired ES8306116A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
ES515398A Granted ES515398A0 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515399A Expired ES8306118A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515396A Expired ES8306115A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
ES515384A Expired ES8306113A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una solfonilurea". |
ES515397A Expired ES8306116A1 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
ES515398A Granted ES515398A0 (es) | 1981-09-02 | 1982-08-31 | "procedimiento para la preparacion de una sulfonilurea". |
Country Status (20)
Country | Link |
---|---|
US (1) | US4542139A (es) |
EP (1) | EP0073507B1 (es) |
JP (1) | JPS5846068A (es) |
KR (1) | KR880002706B1 (es) |
AT (1) | ATE16102T1 (es) |
AU (1) | AU558339B2 (es) |
CA (1) | CA1193603A (es) |
DE (2) | DE3134780A1 (es) |
DK (1) | DK391982A (es) |
ES (6) | ES8306118A1 (es) |
FI (1) | FI76567C (es) |
GR (1) | GR76895B (es) |
HU (1) | HU188805B (es) |
IL (1) | IL66697A0 (es) |
MX (1) | MX154808A (es) |
NO (1) | NO822940L (es) |
NZ (1) | NZ201768A (es) |
PH (1) | PH18218A (es) |
PT (1) | PT75492B (es) |
ZA (1) | ZA826391B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3210063A1 (de) * | 1982-03-19 | 1983-09-22 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
SE9201076L (sv) * | 1992-04-06 | 1993-10-07 | Shimon Slavin | Användningen av gamla läkemedel för behandling av diabetes |
US5681832A (en) * | 1995-02-17 | 1997-10-28 | The United States Of America As Represented By The Department Of Health And Human Services | Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity |
JP2000256323A (ja) * | 1999-01-08 | 2000-09-19 | Japan Tobacco Inc | 2−オキソキノリン化合物及びその医薬用途 |
CA2433158C (en) * | 2000-12-28 | 2011-05-10 | Shionogi & Co., Ltd. | Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor |
ATE540034T1 (de) * | 2005-11-03 | 2012-01-15 | Portola Pharm Inc | Ä4-(6-halo-7-substituierte-2,4-dioxo-1,4-dihydr - 2h-chinazolin-3-yl)-phenylü-5-chloro-thiophen-2 yl-sulfonylharnstoffe und relevante formen und verfahren |
EP2076510A2 (en) * | 2007-05-02 | 2009-07-08 | Portola Pharmaceuticals, Inc. | [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea salts, in different crystalline forms, pharmaceutical compositions thereof, and formulations thereof, for the treatment of thrombosis and trombosis related conditions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3819633A (en) * | 1970-04-01 | 1974-06-25 | Erba Carlo Spa | (iso)quinolyl sulfonylureas having antidiabetic activity |
AT357560B (de) * | 1976-05-18 | 1980-07-25 | Hoechst Ag | Verfahren zur herstellung von neuen (1,2- dihydro-2-oxo-nicotinamido)-alkylbenzolsul- fonylharnstoffen und von deren salzen |
DE2621958A1 (de) * | 1976-05-18 | 1977-12-08 | Hoechst Ag | Benzolsulfonylharnstoffe und verfahren zu ihrer herstellung |
MTP848B (en) * | 1978-06-27 | 1980-06-24 | Hoechst Ag | Sulfonyl ureas process for their manufacture pharmaceutical preparation on the basis of there compounds and their use |
DE2948434A1 (de) * | 1979-12-01 | 1981-06-11 | Hoechst Ag, 6000 Frankfurt | 1-piperidinsulfonylharnstoffe und verfahren zu ihrer herstellung |
DE2951135A1 (de) * | 1979-12-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
-
1981
- 1981-09-02 DE DE19813134780 patent/DE3134780A1/de not_active Withdrawn
-
1982
- 1982-08-28 DE DE8282107938T patent/DE3266953D1/de not_active Expired
- 1982-08-28 AT AT82107938T patent/ATE16102T1/de not_active IP Right Cessation
- 1982-08-28 EP EP82107938A patent/EP0073507B1/de not_active Expired
- 1982-08-31 PH PH27799A patent/PH18218A/en unknown
- 1982-08-31 ES ES515399A patent/ES8306118A1/es not_active Expired
- 1982-08-31 MX MX7875A patent/MX154808A/es unknown
- 1982-08-31 ES ES515395A patent/ES8306114A1/es not_active Expired
- 1982-08-31 GR GR69173A patent/GR76895B/el unknown
- 1982-08-31 ES ES515396A patent/ES8306115A1/es not_active Expired
- 1982-08-31 ES ES515384A patent/ES8306113A1/es not_active Expired
- 1982-08-31 ES ES515397A patent/ES8306116A1/es not_active Expired
- 1982-08-31 NZ NZ201768A patent/NZ201768A/en unknown
- 1982-08-31 FI FI823007A patent/FI76567C/fi not_active IP Right Cessation
- 1982-08-31 NO NO822940A patent/NO822940L/no unknown
- 1982-08-31 KR KR8203918A patent/KR880002706B1/ko active
- 1982-08-31 ES ES515398A patent/ES515398A0/es active Granted
- 1982-09-01 AU AU87892/82A patent/AU558339B2/en not_active Ceased
- 1982-09-01 CA CA000410586A patent/CA1193603A/en not_active Expired
- 1982-09-01 JP JP57150810A patent/JPS5846068A/ja active Pending
- 1982-09-01 DK DK391982A patent/DK391982A/da not_active Application Discontinuation
- 1982-09-01 PT PT75492A patent/PT75492B/pt unknown
- 1982-09-01 HU HU822814A patent/HU188805B/hu unknown
- 1982-09-01 ZA ZA826391A patent/ZA826391B/xx unknown
- 1982-09-01 IL IL66697A patent/IL66697A0/xx unknown
-
1984
- 1984-04-26 US US06/603,987 patent/US4542139A/en not_active Expired - Fee Related
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