ES8305771A1 - Un procedimiento para la preparacion de un ester clorometilico del acido penicilanico. - Google Patents

Un procedimiento para la preparacion de un ester clorometilico del acido penicilanico.

Info

Publication number
ES8305771A1
ES8305771A1 ES510658A ES510658A ES8305771A1 ES 8305771 A1 ES8305771 A1 ES 8305771A1 ES 510658 A ES510658 A ES 510658A ES 510658 A ES510658 A ES 510658A ES 8305771 A1 ES8305771 A1 ES 8305771A1
Authority
ES
Spain
Prior art keywords
penicillanic acid
preparation
acid esters
improved process
penicillanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510658A
Other languages
English (en)
Other versions
ES510658A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8305771A1 publication Critical patent/ES8305771A1/es
Publication of ES510658A0 publication Critical patent/ES510658A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES CLOROMETILICOS DEL ACIDO PEMICILANICO, DE FORMULA (I), EN LA QUE N VALE 0 O 2; Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN MOL COMO MINIMO DE UN DISOLVENTE DE FORMULA X-CH CL, EN LAS QUE R ES ALQUILO C <- , X ES BROMO O YODO, CON LA CONDICION DE QUE CUANDO N ES 2, R ES HIDROGENO. LA REACCION SE LLEVA A CABO A UNA TEMPERATURA ENTRE -20 C Y 25 C, Y EL PRODUCTO OBTENIDO SE SEPARA POR CROMATOGRAFIA SOBRE GEL DE SILICE, DESPUES DE LA CONCENTRACION DE LA MEZCLA A VACIO. ESTOS COMPUESTOS TIENEN APLICACIONES PARA LA SINTESIS DE ESTERES DEL ACIDO PENICILANICO, QUE SE HIDROLIZAN A PENICILINAS ANTIBACTERIANAS.
ES510658A 1981-03-23 1982-03-22 Un procedimiento para la preparacion de un ester clorometilico del acido penicilanico. Granted ES510658A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24648281A 1981-03-23 1981-03-23
US06/341,081 US4381263A (en) 1981-03-23 1982-01-25 Process for the preparation of penicillanic acid esters

Publications (2)

Publication Number Publication Date
ES8305771A1 true ES8305771A1 (es) 1983-04-16
ES510658A0 ES510658A0 (es) 1983-04-16

Family

ID=26938011

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510658A Granted ES510658A0 (es) 1981-03-23 1982-03-22 Un procedimiento para la preparacion de un ester clorometilico del acido penicilanico.
ES519053A Expired ES8403133A1 (es) 1981-03-23 1983-01-17 Un procedimiento para la preparacion de bis-esteres de metanodiol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES519053A Expired ES8403133A1 (es) 1981-03-23 1983-01-17 Un procedimiento para la preparacion de bis-esteres de metanodiol.

Country Status (27)

Country Link
US (1) US4381263A (es)
EP (1) EP0061284B1 (es)
KR (1) KR860001367B1 (es)
AU (1) AU535417B2 (es)
BG (2) BG38940A3 (es)
CA (1) CA1182107A (es)
CS (1) CS228920B2 (es)
DD (2) DD202435A5 (es)
DE (1) DE3270720D1 (es)
DK (1) DK161969C (es)
EG (1) EG15908A (es)
ES (2) ES510658A0 (es)
FI (1) FI75165C (es)
GB (1) GB2095665A (es)
GR (1) GR75939B (es)
HU (1) HU189124B (es)
IE (1) IE52813B1 (es)
IL (1) IL65309A (es)
IN (1) IN157712B (es)
MX (1) MX174205B (es)
NO (2) NO164598C (es)
NZ (1) NZ200067A (es)
PH (2) PH18608A (es)
PL (1) PL130866B1 (es)
PT (1) PT74622B (es)
RO (2) RO83707B (es)
YU (2) YU42762B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704456A (en) * 1985-11-22 1987-11-03 Pfizer Inc. Process for sultamicillin intermediate
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
ES2057876T3 (es) * 1990-04-13 1994-10-16 Pfizer Procedimiento para la obtencion de un intermedio de sultamicilina.
ES2161602B1 (es) * 1999-04-08 2003-02-16 Asturpharma S A Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
CN100384857C (zh) * 2003-11-28 2008-04-30 浙江永宁制药厂 耐β-内酰胺酶的头孢菌素酯化合物及其盐
CN112724162B (zh) * 2020-12-28 2022-06-10 华南农业大学 一种阿莫西林-舒巴坦杂合分子的合成方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5248992B1 (es) * 1971-07-08 1977-12-14
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE50650B1 (en) * 1979-10-11 1986-06-11 Leo Pharm Prod Ltd Method for producing penicillanic acid derivatives

Also Published As

Publication number Publication date
AU535417B2 (en) 1984-03-22
NO820924L (no) 1982-09-24
PH18487A (en) 1985-08-02
YU42904B (en) 1988-12-31
IL65309A (en) 1985-03-31
FI820993L (fi) 1982-09-24
YU162984A (en) 1985-03-20
NO164598B (no) 1990-07-16
RO87039A2 (ro) 1985-05-20
FI75165B (fi) 1988-01-29
ES519053A0 (es) 1984-03-01
CS228920B2 (en) 1984-05-14
IE820658L (en) 1982-09-23
RO83707A (ro) 1984-03-15
RO87039B1 (ro) 1985-05-31
YU62182A (en) 1985-03-20
BG38940A3 (en) 1986-03-14
CA1182107A (en) 1985-02-05
PL235577A1 (en) 1983-03-14
NO164598C (no) 1990-10-24
RO83707B (ro) 1984-03-30
DD202435A5 (de) 1983-09-14
DK127282A (da) 1982-09-24
HU189124B (en) 1986-06-30
GR75939B (es) 1984-08-02
US4381263A (en) 1983-04-26
ES8403133A1 (es) 1984-03-01
BG38938A3 (en) 1986-03-14
YU42762B (en) 1988-12-31
FI75165C (fi) 1988-05-09
DE3270720D1 (en) 1986-05-28
KR860001367B1 (ko) 1986-09-17
IL65309A0 (en) 1982-05-31
AU8176582A (en) 1982-09-30
IN157712B (es) 1986-05-24
MX174205B (es) 1994-04-28
PH18608A (en) 1985-08-21
PT74622A (en) 1982-04-01
KR830009111A (ko) 1983-12-17
PL130866B1 (en) 1984-09-29
DK161969B (da) 1991-09-02
ES510658A0 (es) 1983-04-16
NO831057L (no) 1982-09-24
DK161969C (da) 1992-02-03
EG15908A (en) 1990-08-30
EP0061284A1 (en) 1982-09-29
EP0061284B1 (en) 1986-04-23
DD209835A5 (de) 1984-05-23
NZ200067A (en) 1985-07-12
PT74622B (en) 1984-11-26
GB2095665A (en) 1982-10-06
IE52813B1 (en) 1988-03-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20030210